Using chitosan nanoparticles as drug carriers for the development of a silver sulfadiazine wound dressing

El-Feky, Gina S.; Sharaf, S.; El-Shafei, A.; Hegazy, A.A.

doi:10.1016/j.carbpol.2016.11.054

Cited by 69 publications

(24 citation statements)

References 27 publications

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“…El-Feky et al loaded silver sulfadiazine (SSD) in chitosan nanoparticles as a dressing for burn wound treatment [73]. The particles showed controlled release of SSD, which inhibited the proliferation of Gram-negative and Gram-positive bacteria and Candida albicans in an infected wound.…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

Souto

Ribeiro

Ferreira

et al. 2020

IJMS

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Burn wounds are highly debilitating injuries, with significant morbidity and mortality rates worldwide. In association with the damage of the skin integrity, the risk of infection is increased, posing an obstacle to healing and potentially leading to sepsis. Another limitation against healing is associated with antibiotic resistance mainly due to the use of systemic antibiotics for the treatment of localized infections. Nanotechnology has been successful in finding strategies to incorporate antibiotics in nanoparticles for the treatment of local wounds, thereby avoiding the systemic exposure to the drug. This review focuses on the most recent advances on the use of nanoparticles in wound dressing formulations and in tissue engineering for the treatment of burn wound infections.

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Section: Polymeric Nanoparticlesmentioning

confidence: 99%

New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

Souto

Ribeiro

Ferreira

et al. 2020

IJMS

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“…From the recorded data, it was concluded that, E.E % is inversely proportional with the fibre ratio in both spinning fibres used. From the data, it is also clear that E.E % for the PP/MMT nanocomposite fibre is higher than that of the pure PP fibre due to presence of MMT clay which increases the available active sites for drug adsorption [19].…”

Section: Effect Of Drug /Fibre Concentrationmentioning

confidence: 95%

Preparation and Characterization of Melt Spun Polypropylene / Montmorillonite Nanocomposite Fibre for Ibuprofen Drug Delivery application

Elsayed¹,

Elsharif

Mohamed³

2018

Egypt. J. Chem.

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P OLYPROPYLENE /Montmorillonite clay nanocomposite was prepared after modification of Montmorillonite (MMT) clay using Dimethyl di (hydrogenated tallow) ammonium chloride modifier. The prepared nanocomposite was characterized using scanning electron microscope (SEM), Fourier-transform infrared (FTIR) and thermal gravimetric analysis (TGA). Fibers of pure polypropylene (PP) and polypropylene/montmorillonite clay nanocomposite (PP/MMT) were produced using melt spinning technique and the prepared fibers were characterized using mechanical properties, water absorption in addition to SEM analysis. The results show that the nanocomposite fibers have higher thermal stability, higher mechanical properties, and lower water absorption than pure polypropylene fibers in addition to high degree in homogeneity between polypropylene and MMT clay in polypropylene/montmorillonite nanocomposite. Ibuprofen drug (IBU) was successfully loaded into polypropylene and polypropylene/montmorillonite clay nanocomposite fiber via solvent immersion method with different drug fiber ratio in presence of glyoxal cross linker. Drug release profile was studied for 120 min and the results showed that about 33% from the initial loaded drug was released from the fiber after one hour of release starting time.

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“…In another study, SSD loaded chitosan nanoparticles (CSNPs) embedded into wound dress by padding with glutaraldehyde and investigated for the controlledrelease of SSD into burn wound to control bacterial growth. The dressing formulated in this study showed the continuous delivery of SSD and efficient management due to the longer undisrupted contact time between the drug and the burn wound (El-Feky, Sharaf, El Shafei, & Hegazy, 2017;Hegazy et al, 2013). Delivering the various agents such as vitamin E and C, Aloe vera, curcumin, and melatonin have been reported for management and healing of other types of wounds.…”

Section: Polymeric Npsmentioning

confidence: 99%

Current status and future outlook of nano‐based systems for burn wound management

et al. 2019

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Wound healing process is a natural and intricate response of the body to its injuries and includes a well-orchestrated sequence of biochemical and cellular phenomena to restore the integrity of skin and injured tissues. Complex nature and associated complications of burn wounds lead to an incomplete and prolonged recovery of these types of wounds. Among different materials and systems which have been used in treating the wounds, nanotechnology driven therapeutic systems showed a great opportunity to improvement and enhancement of the healing process of different type of wounds. The aim of this study is to provide an overview of the recent studies about the various nanotechnology-based management of burn wounds and the future outlook of these systems in this area. Laboratory and animal models for assessing the efficacy of these systems in burn wound management also discussed. K E Y W O R D S burn wound, laboratory and animal models, multicomposites, nanomedicine, nanotechnologybased systems, nanoparticles, scaffolds

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Using chitosan nanoparticles as drug carriers for the development of a silver sulfadiazine wound dressing

Cited by 69 publications

References 27 publications

New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

Preparation and Characterization of Melt Spun Polypropylene / Montmorillonite Nanocomposite Fibre for Ibuprofen Drug Delivery application

Current status and future outlook of nano‐based systems for burn wound management

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