Current status and future outlook of nano‐based systems for burn wound management

Abazari, Morteza; Ghaffari, Azadeh; Rashidzadeh, Hamid; Badeleh, Safa Momeni; Maleki, Yaser

doi:10.1002/jbm.b.34535

Cited by 31 publications

(13 citation statements)

References 135 publications

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“…Nanomedicine shows great potential to improve and enhance the healing process in burn wounds. However, future research on nanomedicine, along with toxicology and safety assessments, will be necessary for further development [ 155 ].…”

Section: Surgical Approachesmentioning

confidence: 99%

Review of History of Basic Principles of Burn Wound Management

2022

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Thermal energy is an essential and useful resource to humans in modern society. However, a consequence of using heat carelessly is burns. Burn injuries have various causes, such as exposure to flame, radiation, electrical, and chemical sources. In this study, we reviewed the history of burn wound care while focusing on the basic principles of burn management. Through this review, we highlight the need for careful monitoring and customization when treating burn victims at each step of wound care, as their individual needs may differ. We also propose that future research should focus on nanotechnology-based skin grafts, as this is a promising area for further improvement in wound care.

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Section: Surgical Approachesmentioning

confidence: 99%

Review of History of Basic Principles of Burn Wound Management

2022

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“…In contrast, pig's skin is the utmost analogous to humans. Pigs are not extensively used in wound healing investigations due to the high price and bulky nature of experiments with bigger animals [158]. The processes and drugs for the treatment of wounds are changing quickly, and NPs are being used on wounds in numerous formulations.…”

Section: Lacunae In the Current Researchmentioning

confidence: 99%

Nanomaterial-Based Therapy for Wound Healing

2022

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Poor wound healing affects millions of people globally, resulting in increased mortality rates and associated expenses. The three major complications associated with wounds are: (i) the lack of an appropriate environment to enable the cell migration, proliferation, and angiogenesis; (ii) the microbial infection; (iii) unstable and protracted inflammation. Unfortunately, existing therapeutic methods have not solved these primary problems completely, and, thus, they have an inadequate medical accomplishment. Over the years, the integration of the remarkable properties of nanomaterials into wound healing has produced significant results. Nanomaterials can stimulate numerous cellular and molecular processes that aid in the wound microenvironment via antimicrobial, anti-inflammatory, and angiogenic effects, possibly changing the milieu from nonhealing to healing. The present article highlights the mechanism and pathophysiology of wound healing. Further, it discusses the current findings concerning the prospects and challenges of nanomaterial usage in the management of chronic wounds.

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“…One reason for this is that most basic nanotech research on chronic wound healing is performed in rodent models, such as C57BL/6 mice or Sprague–Dawley rats, even though the skin structure and chronic wound healing processes differ between rodents and humans. 222 The wound healing effects observed in primates, such as humans, may not be as good as those in rats and mice. Meanwhile, the cost of nano-materials and processing platforms required for large-scale preparation also hinder the clinical translation of nanotechnologies.…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

Nanobiotechnology: Applications in Chronic Wound Healing

Jiang¹,

Li²,

Qiu³

et al. 2022

IJN

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Wounds occur when skin integrity is broken and the skin is damaged. With progressive changes in the disease spectrum, the acute wounds caused by mechanical trauma have been become less common, while chronic wounds triggered with aging, diabetes and infection have become more frequent. Chronic wounds now affect more than 6 million people in the United States, amounting to 10 billion dollars in annual expenditure. However, the treatment of chronic wounds is associated with numerous challenges. Traditional remedies for chronic wounds include skin grafting, flap transplantation, negative-pressure wound therapy, and gauze dressing, all of which can cause tissue damage or activity limitations. Nanobiotechnology — which comprises a diverse array of technologies derived from engineering, chemistry, and biology — is now being applied in biomedical practice. Here, we review the design, application, and clinical trials for nanotechnology-based therapies for chronic wound healing, highlighting the clinical potential of nanobiotechnology in such treatments. By summarizing previous nanobiotechnology studies, we lay the foundation for future wound care via a nanotech-based multifunctional smart system.

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Current status and future outlook of nano‐based systems for burn wound management

Cited by 31 publications

References 135 publications

Review of History of Basic Principles of Burn Wound Management

Review of History of Basic Principles of Burn Wound Management

Nanomaterial-Based Therapy for Wound Healing

Nanobiotechnology: Applications in Chronic Wound Healing

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