Preparation and Characterization of Melt Spun Polypropylene / Montmorillonite Nanocomposite Fibre for Ibuprofen Drug Delivery application

Abstract

P OLYPROPYLENE /Montmorillonite clay nanocomposite was prepared after modification of Montmorillonite (MMT) clay using Dimethyl di (hydrogenated tallow) ammonium chloride modifier. The prepared nanocomposite was characterized using scanning electron microscope (SEM), Fourier-transform infrared (FTIR) and thermal gravimetric analysis (TGA). Fibers of pure polypropylene (PP) and polypropylene/montmorillonite clay nanocomposite (PP/MMT) were produced using melt spinning technique and the prepared fibers were characterized using mechanical properties, water absorption in addition to SEM analysis. The results show that the nanocomposite fibers have higher thermal stability, higher mechanical properties, and lower water absorption than pure polypropylene fibers in addition to high degree in homogeneity between polypropylene and MMT clay in polypropylene/montmorillonite nanocomposite. Ibuprofen drug (IBU) was successfully loaded into polypropylene and polypropylene/montmorillonite clay nanocomposite fiber via solvent immersion method with different drug fiber ratio in presence of glyoxal cross linker. Drug release profile was studied for 120 min and the results showed that about 33% from the initial loaded drug was released from the fiber after one hour of release starting time.

Sustainable and safer nanoclay composites for multifaceted applications

“…Furthermore, the controlled drug delivery of an antibacterial drug (tetracycline hydrochloride) to NIH 3T3 mouse embryonic fibroblast cells makes this nanohybrid hydrogel unique for biomedical uses as significantly higher bone regeneration for the nanohybrid scaffold was determined. Elsayed et al 203 conducted an ibuprofen drug release study using melt-spun polypropylene/ montmorillonite nanocomposite fibers, which were thermally stable, and showed improved mechanical properties, and low water absorption due to the high degree of homogeneity of the nanoclay in the polymer matrix. Approximately 33% of the loaded drug was released from the fibers during the first hour of the release time.…”

Recent applications of electrical, centrifugal, and pressurised emerging technologies for fibrous structure engineering in drug delivery, regenerative medicine and theranostics

“…Despite being predominately used in the textile industry, melt spinning's potential in drug delivery (e.g. antibiotics [107], NSAIDs [108]) and biomedical application (e.g. wound healing [109], tissue engineering [110]) has been noticed in recent years.…”