Recent applications of electrical, centrifugal, and pressurised emerging technologies for fibrous structure engineering in drug delivery, regenerative medicine and theranostics

Mehta, Prina; Rasekh, Manoochehr; Patel, Mohammed; Onaiwu, Ekhoerose V.; Nazari, Kazem; Küçük, İsrafil; Wilson, Philippe B.; Arshad, Muhammad Sohail; Ahmad, Zeeshan; Chang, Ming Wei

doi:10.1016/j.addr.2021.05.033

Cited by 35 publications

(24 citation statements)

References 424 publications

(506 reference statements)

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“…Traditionally, coaxial electrospinning must have an electrospinnable sheath fluid for creating the core-sheath nanostructures. However, Yu et al deviated from this concept to develop a series of modified, coaxial electrospinning processes [1][2][3][4][5]. Pure solvents, diluted polymer solutions without electrospinnability, phospholipids, and even nanosuspensions, are reported to act as a sheath working fluid to generate novel, functional nanofibers [1][2][3][4][5].…”

Section: Electrospinningmentioning

confidence: 99%

“…However, Yu et al deviated from this concept to develop a series of modified, coaxial electrospinning processes [1][2][3][4][5]. Pure solvents, diluted polymer solutions without electrospinnability, phospholipids, and even nanosuspensions, are reported to act as a sheath working fluid to generate novel, functional nanofibers [1][2][3][4][5]. However, no studies were found where pure drug solutions were utilized as sheath-working fluids.…”

Section: Electrospinningmentioning

confidence: 99%

“…Drug delivery is always anticipated to be "safe, effective, and convenient" for patients [1][2][3][4][5]. To achieve this goal, drug release profiles must be modified regardless of the drug administration routes [6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

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Electrospun Structural Hybrids of Acyclovir-Polyacrylonitrile at Acyclovir for Modifying Drug Release

Guo

Zhang

et al. 2021

Polymers

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In traditional pharmaceutics, drug–crystalline nanoparticles and drug–polymer composites are frequently explored for their ability to modify drug release profiles. In this study, a novel sort of hybrid with a coating of acyclovir crystalline nanoparticles on acyclovir-polyacrylonitrile composites was fabricated using modified, coaxial electrospinning processes. The developed acyclovir-polyacrylonitrile at the acyclovir nanohybrids was loaded with various amounts of acyclovir, which could be realized simply by adjusting the sheath fluid flow rates. Compared with the electrospun composite nanofibers from a single-fluid blending process, the nanohybrids showed advantages of modifying the acyclovir release profiles in the following aspects: (1) the initial release amount was more accurately and intentionally controlled; (2) the later sustained release was nearer to a zero-order kinetic process; and (3) the release amounts at different stages could be easily allocated by the sheath fluid flow rate. X-ray diffraction results verified that the acyclovir nanoparticles were in a crystalline state, and Fourier-transform infrared spectra verified that the drug acyclovir and the polymer polyacrylonitrile had a good compatibility. The protocols reported here could pave the way for developing new types of functional nanostructures.

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Section: Electrospinningmentioning

confidence: 99%

Section: Electrospinningmentioning

confidence: 99%

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Electrospun Structural Hybrids of Acyclovir-Polyacrylonitrile at Acyclovir for Modifying Drug Release

Guo

Zhang

et al. 2021

Polymers

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“…Nanofibers are among a number of materials that have recently received considerable attention in the fields of both basic and applied research. They enjoy a huge application potential, and their range of use is constantly expanding, especially in the fields of protective textiles [1], tissue engineering [2][3][4], medicine [5], the production of multispecies materials, energy [6,7], air filtration [8][9][10], contaminated water [11,12] and other substances [13], analytical chemistry [14], etc. [15].…”

Section: Introductionmentioning

confidence: 99%

Optimization of the Spinneret Rotation Speed and Airflow Parameters for the Nozzleless Forcespinning of a Polymer Solution

et al. 2022

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This paper addresses the changing of the process parameters of nozzleless centrifugal spinning (forcespinning). The primary aim of this study was to determine the dependence of the final product on the dosing of the polymer, the rotation speed of the spinneret and the airflow in order to determine the extent of the technological applicability of aqueous polyvinyl alcohol (PVA) and its modifications. PVA was chosen because it is a widely used polymeric solution with environmentally friendly properties and good biodegradability. It is used in the health care and food packaging sectors. The nanofibrous layers were produced by means of a mobile handheld spinning device of our own construction. This mobile application of the spinning machine has several limitations compared to stationary laboratory equipment, mainly due to dimensional limitations. The uniqueness of our device lies in the possibility of its actual use outside the laboratory. In addition to improved mobility, another exciting feature is the combination of nozzleless forcespinning and fiber application using airflow. Dosing, the rotation speed of the spinnerets and the targeted and controlled use of air comprise the fundamental technological parameters for many devices that operate on a centrifugal force system. The rotation rate of the spinnerets primarily affects the production of fibers and their quality, while the airflow acts as a fiber transport and drying medium. The quality of the fibers was evaluated following the preparation of a testing set for the fiber layers. The most suitable combinations of rotation speed and airflow were then used in subsequent experiments to determine the ideal settings for the device. The solution was then modified by reducing the concentration to 16% and adding a surfactant, thus leading to a reduction in the diameters of the resulting fibers. The nanofiber layers so produced were examined using a scanning electron microscope (SEM) in order to analyze the number of defects and to statistically evaluate the fiber diameters.

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“…These methods, including also electrospraying and e-jet printing, taking advantage of the facile interactions between the liquids and electrostatic energy for removing the solvents from the fluids rapidly to prepare solid products [48][49][50]. Often, the homogeneous distributions of solutes in the fluids can be propagated into the solid nanofibers or ultra-thin particles [51][52][53]. Thus, both electrospinning and electrospraying are frequently utilized in pharmaceutics for creating amorphous solid dispersions of poorly water-soluble drugs [54][55][56][57].…”

Section: Introductionmentioning

confidence: 99%

Orodispersible Membranes from a Modified Coaxial Electrospinning for Fast Dissolution of Diclofenac Sodium

Ning

Zhou

et al. 2021

Membranes

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The dissolution of poorly water-soluble drugs has been a longstanding and important issue in pharmaceutics during the past several decades. Nanotechnologies and their products have been broadly investigated for providing novel strategies for resolving this problem. In the present study, a new orodispersible membrane (OM) comprising electrospun nanofibers is developed for the fast dissolution of diclofenac sodium (DS). A modified coaxial electrospinning was implemented for the preparation of membranes, during which an unspinnable solution of sucralose was explored as the sheath working fluid for smoothing the working processes and also adjusting the taste of membranes. SEM and TEM images demonstrated that the OMs were composed of linear nanofibers with core-sheath inner structures. XRD and ATR-FTIR results suggested that DS presented in the OMs in an amorphous state due to the fine compatibility between DS and PVP. In vitro dissolution measurements and simulated artificial tongue experiments verified that the OMs were able to release the loaded DS in a pulsatile manner. The present protocols pave the way for the fast dissolution and fast action of a series of poorly water-soluble active ingredients that are suitable for oral administration.

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Recent applications of electrical, centrifugal, and pressurised emerging technologies for fibrous structure engineering in drug delivery, regenerative medicine and theranostics

Cited by 35 publications

References 424 publications

Electrospun Structural Hybrids of Acyclovir-Polyacrylonitrile at Acyclovir for Modifying Drug Release

Electrospun Structural Hybrids of Acyclovir-Polyacrylonitrile at Acyclovir for Modifying Drug Release

Optimization of the Spinneret Rotation Speed and Airflow Parameters for the Nozzleless Forcespinning of a Polymer Solution

Orodispersible Membranes from a Modified Coaxial Electrospinning for Fast Dissolution of Diclofenac Sodium

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