In traditional pharmaceutics, drug–crystalline nanoparticles and drug–polymer composites are frequently explored for their ability to modify drug release profiles. In this study, a novel sort of hybrid with a coating of acyclovir crystalline nanoparticles on acyclovir-polyacrylonitrile composites was fabricated using modified, coaxial electrospinning processes. The developed acyclovir-polyacrylonitrile at the acyclovir nanohybrids was loaded with various amounts of acyclovir, which could be realized simply by adjusting the sheath fluid flow rates. Compared with the electrospun composite nanofibers from a single-fluid blending process, the nanohybrids showed advantages of modifying the acyclovir release profiles in the following aspects: (1) the initial release amount was more accurately and intentionally controlled; (2) the later sustained release was nearer to a zero-order kinetic process; and (3) the release amounts at different stages could be easily allocated by the sheath fluid flow rate. X-ray diffraction results verified that the acyclovir nanoparticles were in a crystalline state, and Fourier-transform infrared spectra verified that the drug acyclovir and the polymer polyacrylonitrile had a good compatibility. The protocols reported here could pave the way for developing new types of functional nanostructures.

Herb medicines are popular for safe application due to being a source of natural herbs. However, how to deliver them in an efficacious and convenient manner poses a big challenge to researchers. In this study, a new concept is demonstrated that the electrospun polymer-based hybrid films can be a platform for promoting the delivery of a mixture of active herb extract, i.e., Lianhua Qingwen Keli (LQK), also a commercial traditional Chinese patent medicine. The LQK can be co-dissolved with the filament-forming polymeric polyvinylpyrrolidone K60 and a sweeter sucralose to prepare an electrospinnable solution. A handheld electrospinning apparatus was explored to transfer the solution into solid nanofibers, i.e., the LQK-loaded medicated films. These films were demonstrated to be composed of linear nanofibers. A puncher was utilized to transfer the mat into circular membrane a diameter of 15 mm. Two self-created methods were developed for disclosing the dissolution performances of the electrospun mats. Both the water droplet experiments and the wet paper (mimic tongue) experiments verified that the hybrid films can rapidly disintegrate when they encounter water and release the loaded LQK in an immediate manner. Based on the reasonable selections of polymeric excipients, the present protocols pave a way for delivering many types of active herb extracts in an effective and convenient manner.

A new 2D DOA estimation method for coherently distributed (CD) source is proposed. CD sources model is constructed by using Taylor approximation to the generalized steering vector (GSV), whereas the angular and angular spread are separated from signal pattern. The angular information is in the phase part of the GSV, and the angular spread information is in the module part of the GSV, thus enabling to decouple the estimation of 2D DOA from that of the angular spread. The array received data is used to construct three-dimensional (3D) enhanced data matrix. The 2D DOA for coherently distributed sources could be estimated from the enhanced matrix by using 3D matrix pencil method. Computer simulation validated the efficiency of the algorithm.

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The effective implementations of "Scientific Research Nurtures Teaching" to students can benefit the fostering of professional talents from universities. The metabolism of professional knowledge renewing determines that the key role of professional education and the formation of students practical ability in their university life, and also the abundant professional research topics can ensure fruitful teaching materials. With scientific researches on coaxial electrospraying as an example, this paper has explained how to efficaciously implement "Scientific Research Nurtures Teaching" to both undergraduate and postgraduate students. Under the wise instructions of "three-all education" spirits, 1) all-process of coaxial electrospraying can be useful materials for nurturing teaching such as the raw materials and experimental conditions, implementation of the coaxial electrospraying processes, analyses of the resulted in nano products, and the writing of patents or research articles; 2) all-staff around the coaxial electrospraying can take an active part in the teaching, such as the supervisors, the instructor, the administrative staff, the academic visitor, and safety officers; 3) all-round education can be carried out for nurturing teaching and fostering the students' abilities of practical ability, organization and management ability, crisis resolution ability, innovation ability, organization skills, the spirit of unity and cooperation besides professional ability.

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