2021
DOI: 10.3390/polym13244286
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Abstract: In traditional pharmaceutics, drug–crystalline nanoparticles and drug–polymer composites are frequently explored for their ability to modify drug release profiles. In this study, a novel sort of hybrid with a coating of acyclovir crystalline nanoparticles on acyclovir-polyacrylonitrile composites was fabricated using modified, coaxial electrospinning processes. The developed acyclovir-polyacrylonitrile at the acyclovir nanohybrids was loaded with various amounts of acyclovir, which could be realized simply by … Show more

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Cited by 73 publications
(50 citation statements)
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“…Nowadays, coaxial electrospinning is also booming. For example, Lv et al [ 96 ] used modified coaxial electrospinning technology to prepare core–sheath nanostructure fibers for drug release.…”
Section: Electrospinningmentioning
confidence: 99%
See 1 more Smart Citation
“…Nowadays, coaxial electrospinning is also booming. For example, Lv et al [ 96 ] used modified coaxial electrospinning technology to prepare core–sheath nanostructure fibers for drug release.…”
Section: Electrospinningmentioning
confidence: 99%
“…The application of single-fluid electrospinning is limited by the materials. Through the multifluid electrospinning process, more diversified nanostructured fibers can be prepared, which can be used in such fields as controlled drug release [ 96 , 107 , 108 , 109 , 110 ], wound dressing [ 111 ], food packaging [ 112 , 113 , 114 , 115 ], antibacterial materials [ 116 , 117 ], tissue engineering [ 118 ], and water treatment [ 119 , 120 ]. However, due to the limitation of polymer spinnability in the early stage, there is little research on the preparation of air-filtration fiber membranes by the multifluid electrospinning process.…”
Section: Electrospinningmentioning
confidence: 99%
“…In contrast, shown in the right column of Figure 1 , water-insoluble and bio-degradable polymers are often exploited to prepare casting films for providing drug sustained release profiles [ 37 , 38 , 39 , 40 , 41 ]. As the polymeric carriers are insoluble in water, the loaded drug molecules must be freed into the dissolution medium through a diffusion mechanism [ 42 , 43 , 44 , 45 ]. This is also the dominant mechanism for many drug molecules released from their inorganic carriers, such as carbon nano tubes, silicon dioxide, and little molecules such as lipids [ 46 , 47 , 48 , 49 ].…”
Section: Introductionmentioning
confidence: 99%
“…In recent years, drug delivery systems have attracted widespread attention due to their ability to deliver the correct number of drugs to the proper place [ 1 , 2 , 3 , 4 , 5 ], especially for poorly soluble drugs. More than two-thirds of promising drugs on the market have limited biomedical functions due to dissolution problems [ 6 , 7 , 8 ]. Thus, many drug delivery systems are exploited to improve the bioavailability of poorly soluble drugs, such as nanoparticles [ 9 , 10 , 11 , 12 , 13 ], hydrogels [ 14 , 15 ], 3D printing [ 16 , 17 ], electrospun fibers [ 18 , 19 , 20 , 21 ], nanocapsules [ 22 ], and microspheres [ 23 ].…”
Section: Introductionmentioning
confidence: 99%