Usefulness of sum of the thickness of plaque in the carotid artery for predicting the presence and the extent of the coronary artery disease in patients with type 2 diabetes mellitus without known coronary artery disease

Akazawa, Shoichi; Tojikubo, Masayuki; Nakano, Yuko; Nakamura, Satoe; Kawasaki, Terukazu; Koga, Nobuhiko

doi:10.1016/j.diabres.2011.11.019

Cited by 9 publications

(10 citation statements)

References 22 publications

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“…The coefficients of interassay variation of the CIMT and plaque score were 5.5% and 6.4%, respectively. The intra-assay coefficient for the variation of CIMT and PS has been reported previously 10 .…”

Section: Methodsmentioning

confidence: 93%

Usefulness of carotid plaque (sum and maximum of plaque thickness) in combination with intima‐media thickness for the detection of coronary artery disease in asymptomatic patients with diabetes

Akazawa

Tojikubo

Nakano

et al. 2015

J of Diabetes Invest

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Aims/IntroductionThe usefulness of markers of carotid plaque, such as sum (PS) and maximum (P‐max) of the plaque thickness, in combination with intima‐media thickness in the common carotid artery (CIMT) for the detection of obstructive coronary artery disease (CAD) was investigated in patients with type 2 diabetes without known CAD.Materials and MethodsB‐mode ultrasonographic scanning of the carotid artery and multislice computed tomography coronary angiography were carried out in 332 asymptomatic patients with type 2 diabetes.ResultsFor the presence of obstructive CAD when incorporating PS or P‐max to standard risk factors in a multiple logistic regression model, the classification ability in PS and P‐max increased greatly (area under the curve [AUC] 0.827 vs 0.720 [net reclassification index {NRI} = 0.652, P < 0.01] and AUC 0.820 vs 0.720 [NRI = 0.775, P < 0.01], respectively), and it in CIMT increased slightly (AUC 0.740 vs 0.720, NRI = 0.230, P = 0.041). Furthermore, the classification abilities for a model with interaction terms between PS* or P‐max* and CIMT were statistically larger than those for a model without interaction terms (AUC 0.833 vs 0.827 [NRI = 0.411, P < 0.01] and 0.823 vs 0.820 [NRI = 0.269, P < 0.05], respectively). Partitioning showed the patients in the values of the PS <2.6 mm and CIMT <0.725 mm (100%), or in P‐max <2.1 mm and CIMT <0.725 mm (95.4%), did not have obstructive CAD, whereas those in the values of PS ≧2.6 mm, presence of hyperlipidemia and CIMT ≧0.675 mm (84%) or those in the value of P‐max ≧2.1 mm and body mass index ≧24 (91.7%) had obstructive CAD.ConclusionsAlthough the P‐max and PS in the carotid artery were useful as detectors of CAD, combining them with CIMT provided a much superior first‐line screening method in detecting CAD in asymptomatic patients with diabetes.

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Section: Methodsmentioning

confidence: 93%

Usefulness of carotid plaque (sum and maximum of plaque thickness) in combination with intima‐media thickness for the detection of coronary artery disease in asymptomatic patients with diabetes

Akazawa

Tojikubo

Nakano

et al. 2015

J of Diabetes Invest

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“…All subjects were rested for 10 minutes before getting the carotid ultrasound, and change to the supine position so as to fully expose their lateral neck, meanwhile, tilting their head to the contralateral side, and the procedure is operated by a specialist of ultrasound doctor, using Chinese Sonoscape S20 color Doppler ultrasound system. The standard common high-frequency probe is used, and the probe rate is 5 10 MHz. Both common carotid arteries and their bifurcations, and internal carotid artery are detected in turn, and the intimal thickness of the tube wall is observed.…”

Section: Carotid Artery Ultrasoundmentioning

confidence: 99%

“…Carotid atherosclerosis is not only related to the severity of ischemic heart and brain vascular disease, and it is also a window into the atherosclerotic state of other blood vessels throughout the body. Therefore, early detection of the condition of the inner wall of the carotid artery by B-ultrasound has important clinical signi cance and can well predict the patient's risk of ASCCVD [5], [6]. The serum markers of vulnerable plaques in circulation are sensitive, highly operable, accurate, acceptable to patients and guide clinical decisions for clinicians, and can predict the risk of acute cardiovascular and cerebrovascular events and complications in patients.…”

Section: Introductionmentioning

confidence: 99%

Early identification of carotid vulnerable plaque in asymptomatic patients

Jiao

Qin

Zhang

et al. 2020

Preprint

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Background This study was to explore the influencing factors of atherosclerotic plaque formation and stability in patients with asymptomatic carotid atherosclerotic plaques, so as to identify the vulnerable plaques at early stage, and then find high-risk group of cardio-cerebrovascular events for early clinical intervention to reduce related mortality and disability. Methods A total of 302 enrolled patients with asymptomatic carotid atherosclerotic plaques were divided into 3 groups based on the results of carotid artery color Doppler ultrasound: atherosclerotic unstable plaque (UP) group, atherosclerotic stable plaque (SP) group, and control group without plaques. Serum markers were measured by ELISA. χ2 test, t test, Pearson correlation analysis, and Logistic multivariate regression analysis were used in the analysis, and P < 0.05 was considered statistically significant. Results It revealed that diabetes, high MMP-9, LOX-1and YKL-40 were independent risk factors for unstable plaque formation. The area under the curve (AUC) of serum markers combined with MMP-9, LOX-1 and YKL-40 was 0.850, with sensitivity 87.67%, specificity 81.13%, and diagnostic accuracy 84.92%, which was significantly better than the individual diagnostic efficacy of other three factors. The accuracy rate of Crouse Plaque Score (CPS) in the diagnosis of vulnerable plaques was 61.90%, the 10-year ICVD diagnosis accuracy rate was 56.75%, and the diagnostic accuracy of serum markers was significantly better than CPS and 10-year ICVD. Conclusion Serum markers predict potential atherosclerotic cardiovascular and cerebrovascular disease (ASCCVD) patients better than plaque scores and 10-year ICVD. This study provides a new idea for the early identification of high-risk population of cardiovascular and cerebrovascular events by combining 10-year ICVD and serum markers.

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“…It is a one‐dimensional measurement between intima and adventia‐media. The biological rationale for measuring IMT is that pathological intimal thickening is one of the earliest stages of atherosclerosis and it has been shown to predict cardiovascular events (7) not only in patients with coronary artery disease but also in asymptomatic patients and in those with type 2 diabetes, in which it has been proven to be an important screening test (8).…”

Section: Imaging Of Atherosclerosismentioning

confidence: 99%

Multi‐Modal Imaging Technologies in Cardiovascular Risk Assessment

Casciani¹,

Vincentiis

Colaiacomo³

et al. 2012

Ther Apher Dial

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Atherosclerotic plaques can be responsible for life-threatening cardiovascular and cerebrovascular events. Some features of the plaque, such as a thin fibrous cap, large necrotic core, macrophage infiltration, neovascularization, and intraplaque hemorrhage, are associated with a major risk of such events and so their assessment is fundamental. Novel imaging techniques, each one with its own strength and drawbacks, can help in the evaluation and quantification of atherosclerosis. An analysis of the recent literature was carried out. The different techniques were compared by evaluating the accuracy of each one in the detection and assessment of the atherosclerotic plaque's features named above.

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Usefulness of sum of the thickness of plaque in the carotid artery for predicting the presence and the extent of the coronary artery disease in patients with type 2 diabetes mellitus without known coronary artery disease

Cited by 9 publications

References 22 publications

Usefulness of carotid plaque (sum and maximum of plaque thickness) in combination with intima‐media thickness for the detection of coronary artery disease in asymptomatic patients with diabetes

Usefulness of carotid plaque (sum and maximum of plaque thickness) in combination with intima‐media thickness for the detection of coronary artery disease in asymptomatic patients with diabetes

Early identification of carotid vulnerable plaque in asymptomatic patients

Multi‐Modal Imaging Technologies in Cardiovascular Risk Assessment

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