Usefulness of carotid plaque (sum and maximum of plaque thickness) in combination with intima‐media thickness for the detection of coronary artery disease in asymptomatic patients with diabetes
Abstract:Aims/IntroductionThe usefulness of markers of carotid plaque, such as sum (PS) and maximum (P‐max) of the plaque thickness, in combination with intima‐media thickness in the common carotid artery (CIMT) for the detection of obstructive coronary artery disease (CAD) was investigated in patients with type 2 diabetes without known CAD.Materials and MethodsB‐mode ultrasonographic scanning of the carotid artery and multislice computed tomography coronary angiography were carried out in 332 asymptomatic patients wit… Show more
“…These modalities reflect different aspects of atherosclerosis. 8,22 In our study, the addition of CIMT did not improve the discrimination and reclassification of obstructive CAD, which was consistent with previous studies. However, previous studies found that the CIMT had slight or no significant incremental value over Framingham Risk Score.…”
Section: Discussionsupporting
confidence: 92%
“…9,11,12,22 A meta-analysis of 11 studies also supported this finding. 9,11,12,22 A meta-analysis of 11 studies also supported this finding.…”
Section: Discussionmentioning
confidence: 75%
“…These findings indicate CIMT may be biologically distinct from plaque. 22 We have conducted a preliminary study with 515 patients who had the data of maximum plaque height. 24 Plaque is more related to atherosclerotic processes.…”
Total number of plaques, area of maximum soft, hard and mixed plaques showed significantly incremental prediction ability over CRF. A nomogram based on these factors provided an intuitive and practical method in detecting CAD.
“…These modalities reflect different aspects of atherosclerosis. 8,22 In our study, the addition of CIMT did not improve the discrimination and reclassification of obstructive CAD, which was consistent with previous studies. However, previous studies found that the CIMT had slight or no significant incremental value over Framingham Risk Score.…”
Section: Discussionsupporting
confidence: 92%
“…9,11,12,22 A meta-analysis of 11 studies also supported this finding. 9,11,12,22 A meta-analysis of 11 studies also supported this finding.…”
Section: Discussionmentioning
confidence: 75%
“…These findings indicate CIMT may be biologically distinct from plaque. 22 We have conducted a preliminary study with 515 patients who had the data of maximum plaque height. 24 Plaque is more related to atherosclerotic processes.…”
Total number of plaques, area of maximum soft, hard and mixed plaques showed significantly incremental prediction ability over CRF. A nomogram based on these factors provided an intuitive and practical method in detecting CAD.
“…FBS, UAC, mean IMT, and plaque score were identified as risk factors for CAD in previous studies, and those reports may support our present findings. Under antihypertensive medication, the morning pulse pressure was higher in our CAD patients.…”
Section: Discussionsupporting
confidence: 92%
“…General physiological methods to predict the onset of CAD have been described. IMT obtained by carotid ultrasonography has been reported to be an important surrogate marker for the prediction of CAD and stroke in general populations, and increased carotid plaque was shown to be an independent predictor of the presence and severity of CAD . However, due to difficulties in studying the coronary microcirculation directly, it is still unclear whether aspects of coronary microcirculation could be used to predict CAD.…”
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