Usefulness of Bicuspid Aortic Valve Phenotype to Predict Elastic Properties of the Ascending Aorta

Schaefer, Benjamin M.; Lewin, Mark B.; Stout, Karen; Byers, Peter H.; Otto, Catherine M

doi:10.1016/j.amjcard.2006.09.118

Cited by 136 publications

(94 citation statements)

References 15 publications

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“…A comparative echocardiographic evaluation of BAV patients with different aortic valve cusp fusion patterns brought comparable findings: fusion of the left coronary and right coronary cusps was associated with a larger aortic root diameter and a smaller aortic arch, than was fusion of the right coronary and non-coronary cusps (Schaefer et al, 2007). Moreover, fusion of the left coronary and right coronary cusps correlated with a higher aortic stiffness index and lower distensibility at the level of the aortic root.…”

Section: Different Cusps Fusion Patterns In Bav Diseasementioning

confidence: 70%

“…This phenotypic classification has been proposed as a clinical and a research tool in order to precisely define BAV subgroups based on the combination of cusp morphology and proximal aortic shape. Another retrospective echocardiographic study demonstrated, analogously with Schaefer et al (2007Schaefer et al ( , 2008, that fusion of the right coronary and non-coronary cusps correlated with the more rapid growth of ascending aortic diameter in the pediatric population (Holmes et al, 2007). The pathogenetic background for clinical observation of the specific aortic shapes in BAV patients with different morphologic cusp fusion patterns has been elucidated in detailed in vivo rheological studies using sophisticated 4D magnetic resonance imaging .…”

Section: Different Cusps Fusion Patterns In Bav Diseasementioning

confidence: 99%

See 1 more Smart Citation

Novel Phenotypes in Bicuspid Aortic Valve Disease

Girdauskas¹,

Borger²,

Kuntze³

2011

Aortic Valve

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Section: Different Cusps Fusion Patterns In Bav Diseasementioning

confidence: 70%

Section: Different Cusps Fusion Patterns In Bav Diseasementioning

confidence: 99%

Novel Phenotypes in Bicuspid Aortic Valve Disease

Girdauskas¹,

Borger²,

Kuntze³

2011

Aortic Valve

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“…In a few recent studies, abnormal elastic properties of the aortic annulus and ascending aorta were detected in adult patients with BAV (11)(12)(13)(14)(15). However, the elastic properties of the abdominal aorta have not been investigated before in adults or children with BAV.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies reported that adult patients with BAV have abnormal elastic properties of the ascending aorta (11)(12)(13)(14)(15). Increase in aortic stiffness may also increase the risk for dissection (12).…”

Section: Introductionmentioning

confidence: 99%

Elastic properties of the abdominal aorta in the children with bicuspid aortic valve: an observational study

Gürses¹,

Özyürek²,

Levent³

et al. 2012

Anadolu Kardiyol Derg

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Objective: Abnormalities of the aortic root and ascending aorta are common in patients with a bicuspid aortic valve (BAV). The aim of this study was to evaluate the stiffness of the abdominal aorta in children with BAV. Methods: In this cross-sectional observational study, we evaluated 35 children with normally functioning or mildly regurgitant BAV and 35 healthy children as controls. All children were noninvasively evaluated with transthoracic echocardiography. Annulus of aorta and abdominal aorta diameters were measured. Aortic strain (S), pressure strain elastic modulus (Ep), pressure strain normalized by diastolic pressure (Ep * ), aortic stiffness β index (βSI) and, aortic distensibility (DIS) were calculated using the measured data. In evaluation of the data Student's t-test, Chi-square test, Pearson's correlation and multivariate linear regression analysis were used. Results: Diameter of the aortic annulus was found significantly larger in the children with BAV than the control group (p<0.05). The abdominal aorta systolic and diastolic diameters were similar in the two groups (p>0.05). The children with BAV exhibited significantly lower S (0.210±0.04/0.267±0.07, p<0.001) and DIS (1.04±0.2/1.4±0.4 10 -6 cm 2 dyne -1 , p<0.001); and higher Ep (200±39/153±47 N/m -2 , p<0.001), Ep * (3.42±0.9/2.5±0.9, p<0.001) and βSI (1.1±0.3/0.84±0.3, p<0.001) than the control group. There was no correlation between the systolic and diastolic diameters of abdominal aorta and aortic elasticity parameters (p>0.05). Conclusion: Bicuspid aortic valve is associated with an increased abdominal aortic stiffness in children. However, impaired abdominal aortic elasticity is not due to abdominal aortic dilatation. These findings require validation by further studies. (Anadolu Kardiyol Derg 2012; 12: 413-9)

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“…45 Beta-blockade therapy 46 and angiotensin-converting enzyme inhibition appear to reduce aortic stiffness, which may in turn slow aortic dilation and aortic root replacement. 47 In both children and adults, isolated bicuspid aortic valve may be associated with progressive dilation of the ascending aorta and increased aortic stiffness. 48 This may be due to a common developmental defect, which is hypothesized to be responsible for the coexistence of bicuspid aortic valve and aortic root enlargement.…”

Section: Distensibilitymentioning

confidence: 99%

Elastic Properties of the Ascending Aorta in Healthy Children and Adolescents

Hauser

Kühn

Petzuch

et al. 2013

Circ J

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Background:Compliance of the aorta is important in maintaining normal cardiovascular physiology. Pathological conditions can induce changes in elastic properties, having profound effects on their prognosis. The aim of this study was to establish age-related reference values for distensibility and wall stiffness index of the ascending aorta. Methods and Results:A total of 165 normal subjects (mean age, 11.92±4.0 years) were investigated on transthoracic echocardiography. Ascending aortic diameter was recorded in M-mode above the sinotubular junction. Blood pressure was measured simultaneously at the right arm. Aortic pulse pressure, distensibility and aortic wall stiffness index were calculated offline. Distensibility decreased significantly with age (r=−0.462, P<0.001); the regression line indicated an average decrease of 5.1 10 −3 kPa −1 (95% confidence interval [CI]: 3.9-6.8 10 −3 kPa −1 ) per year. Significant correlations could be found between distensibility and weight, height, body surface area (BSA) and body mass index (BMI) (P<0.001). Stiffness index increased significantly with age (r=0.399, P<0.001); the regression line indicated an average increase of 0.066 (95% CI: 0.047-0.085) per year; significant correlations could be found between wall stiffness index and weight, height, BSA and BMI (P<0.001). The 2.5th and 97.5th percentiles of the distribution of distensibility and stiffness index related to age, weight, height, BSA and BMI were calculated. Conclusions:Normal values of arterial elastic properties throughout childhood and adolescence have been provided, and might serve as a reference for individuals with cardiovascular and metabolic disease. (Circ J 2013; 77: 3007 -3014)

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Usefulness of Bicuspid Aortic Valve Phenotype to Predict Elastic Properties of the Ascending Aorta

Cited by 136 publications

References 15 publications

Novel Phenotypes in Bicuspid Aortic Valve Disease

Novel Phenotypes in Bicuspid Aortic Valve Disease

Elastic properties of the abdominal aorta in the children with bicuspid aortic valve: an observational study

Elastic Properties of the Ascending Aorta in Healthy Children and Adolescents

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