Usefulness of a novel method for the screening of deep vein thrombosis by using a combined D-dimer- and age-based index before total hip arthroplasty

Imai, Norio; Miyasaka, Dai; Shimada, Hayato; Suda, Kazuaki; Ito, Tomoyuki; Endo, Naoto

doi:10.1371/journal.pone.0172849

Cited by 21 publications

(27 citation statements)

References 19 publications

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“…Although previous literature has established the incidence and risk factors of DVT after primary THA, a lack of consensus has been conducted [ 16 ]. Our results have indicated an incidence of 9.5% for DVT after unilateral primary THA, which was relatively higher than previous reports [ 3 , 17 ]. We considered that the different races, ages, and inclusion criteria might lead to the different results.…”

Section: Discussioncontrasting

confidence: 72%

Plasminogen activator inhibitor-1: a risk factor for deep vein thrombosis after total hip arthroplasty

et al. 2018

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BackgroundThe onset of deep vein thrombosis (DVT) in patients after total hip arthroplasty (THA) may expand or enlarge and subsequently lead to significant mortality. The objective of this study was to investigate potential risk factors for DVT in patients after THA.MethodsEligible patients with hip joint diseases who were scheduled for unilateral primary THA at our hospital were prospectively included into this study. The demographic and clinical features, preoperative plasma biomarkers were detailed, recorded, and compared. The multiple logistic regression analysis was used to evaluate potential risk factors for DVT.ResultsA total of 214 subjects were enrolled into our study cohort for the final analysis, and 23 of them have suffered DVT with an incidence of 9.5%. The performance of logistic regression analysis showed that preoperative expression of plasminogen activator inhibitor-1 (PAI-1) was an independent risk factor for the onset of DVT in patients after THA (OR 1.18, 95% CI 1.04–1.29; p = 0.011).ConclusionsOur study indicated preoperative plasma PAI-1 expression as an independent risk factor for DVT in patients who underwent THA.

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Section: Discussioncontrasting

confidence: 72%

Plasminogen activator inhibitor-1: a risk factor for deep vein thrombosis after total hip arthroplasty

et al. 2018

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“…In previous reports, Norio Imai et al demonstrated that age and D-dimer index can be useful in screening patients for DVTs before THA. [13] The conclusion was similar to us. Moreover, age-adjusted D-dimer value was calculated as patients' age times 0.01(µg/mL) by Henrike J Schouten et al [10] They drew conclusions that age-adjusted D-dimer value can increase speci city, whereas sensitivity was not.…”

Section: Discussionsupporting

confidence: 84%

Performance of age-adjusted D-dimer values for predicting DVT before the knee and hip arthroplasty

Qing

Yao

et al. 2020

Preprint

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Purpose: To compare the specificity and sensitivity of preoperative D-dimer and age-adjusted D-dimer value for predicting the incidence of the DVT preoperatively in total joint arthroplasty (TJA) patients.Methods: We enrolled 406 patients finally above 50 years old. Everyone had done ultrasonography bedside, and D-dimer concentrations were collected before surgery. The D-dimer and age-adjusted D-dimer cut-off was calculated by multiple logistic regression and receiver operating curve (ROC) analyses.Results: A total of 39 patients had found asymptomatic deep vein thrombosis (DVT) by ultrasonography. The age (odds ratio [OR]: 1.067; p=0.003) and D-dimer (OR:1.331; p=0.025) were related to the existence of DVT. For conventional D-dimer and age-adjusted D-dimer value, the area under the curves (AUCs) were 0.685 (0.499-0.696) and 0.795 (0.611-0.881), respectively.Conclusion: Compared to traditional D-dimer, age-adjusted D-dimer showed better performance in screening DVT, which was useful clinically.

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“…Deep venous thrombosis (DVT) is a common complication of SCI, with clinical features of lower-limb swelling and edema. Serum D-dimer is a breakdown product of fibrin, which serves as a useful diagnostic marker for DVT [ 19 – 22 ]. It has been reported that the incidence rate of DVT was 6.55% in acute SCI patients, and the incidence rate of NHO was 8%, with a correlation between the DVT and NHO [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Association of α2-HS Glycoprotein with Neurogenic Heterotopic Ossification in Patients with Spinal Cord Injury

Dong

Cao

et al. 2017

Med Sci Monit

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BackgroundThe aim of this study was to explore the relationship between the α2-HS glycoprotein concentrations in serum and the occurrence of neurogenic heterotopic ossification (NHO) in patients with spinal cord injury (SCI).Material/MethodsDuring the period between January 2011 and January 2012, 75 patients (67 male) with paraplegia caused by spinal cord injury were enrolled. The patients were divided into 2 groups in accordance with the occurrence of heterotopic ossification based on the results high-frequency ultrasound on the bilateral hip joint. The levels of α2-HS glycoprotein, C-reactive protein (CRP), D-dimer, and bone morphogenetic protein (BMP) were detected by ELISA.ResultsWe found a significant decrease of α2-HS glycoprotein in SCI patients with NHO compared to SCI patients without NHO. In contrast, a significant elevation of serum calcium, D-dimer, BMP, and CRP was observed in SCI patients with NHO. The degree of maturity of NHO did not influence the level of α2-HS glycoprotein. Multivariate liner regression analysis showed that the level of serum α2-HS glycoprotein was correlated with CRP and spasticity.ConclusionsThe decreased level of α2-HS glycoprotein may be related to the formation of neurogenic heterotopic ossification in patients with spinal cord injury. Our results suggest that α2-HS glycoprotein might be a risk factor for NHO in patients with SCI.

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Usefulness of a novel method for the screening of deep vein thrombosis by using a combined D-dimer- and age-based index before total hip arthroplasty

Cited by 21 publications

References 19 publications

Plasminogen activator inhibitor-1: a risk factor for deep vein thrombosis after total hip arthroplasty

Plasminogen activator inhibitor-1: a risk factor for deep vein thrombosis after total hip arthroplasty

Performance of age-adjusted D-dimer values for predicting DVT before the knee and hip arthroplasty

Association of α2-HS Glycoprotein with Neurogenic Heterotopic Ossification in Patients with Spinal Cord Injury

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