Use of Statins, Anticoagulants, Antiaggregants and Antiarrhythmic Drugs in Patients With COVID-19. The Agreed Experts’ Position of Russian Society of Cardiology, Eurasian Association of Therapists, National Society on Atherothrombosis, Societies of Experts in Urgent Cardiology, Eurasian Arrhythmology Association

Shlyakhto, Ye. V.; Arutyunov, G. P.; Belenkov, Yu. N.; Tarlovskaya, E. I.; Конради, А. О.; Панченко, Е. П.; Yavelov, I. S.; Tereshchenko, S. N.; Ардашев, А.; Arutyunov, A G; Grigorieva, N. Yu.; Джунусбекова, Г А; Драпкина, О. М.; Козиолова, Н. А.; Комаров, А. Л.; Кропачева, Е. С.; Malchikova, S. V.; Mitkovskaya, N. P.; Orlova, Yа A; Петрова, М. М.; Ребров, А. П.; Sisakian, Hamayak; Skibitsky, V. V.; Sugraliyev, Akhmetzhan; Фомин, И. В.; Чесникова, А. И.; Шапошник, И. И.; Zhelyakov, E.; Канорский, С. Г.; Kolotsey, Ludmila; Snezhitskiy, V. A.

doi:10.18087/cardio.2020.6.n1180

Cited by 11 publications

(7 citation statements)

References 33 publications

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Section: Discussionmentioning

confidence: 99%

“…In addition to severe hypoxia, coagulopathy with the development of disseminated intravascular coagulation (DIC) syndrome was reported in COVID-19 patients [ 21 ]. Therefore, when hospitalizing patients with suspected or confirmed COVID-19, experts recommend to determine blood levels of D-dimer, fibrinogen and other parameters of the blood coagulation system, to count the number of platelets in the blood, and, only in accordance with the test results, to prescribe antithrombotic therapy [ 21 ]. It is well known that the D-dimer blood level exceeding the upper limit of normal values more than 2 times indicates an increased risk of deep vein thrombosis of the lower extremities and thromboembolism of the pulmonary arteries [ 10 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

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Analysis of Some Physiological and Biochemical Indices in Patients with Covid-19 Pneumonia Using Mathematical Methods

Громов

Rogacheva

Barulina

et al. 2021

J Evol Biochem Phys

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The aim of the work was to conduct a retrospective analysis of the clinical data of patients with pneumonia caused by the SARS-CoV-2 virus, and to determine via mathematical methods the significance of some physiological and biochemical indices as predictive markers of an unfavorable outcome of the disease. A random cohort of patients with COVID-19 pneumonia numbered 209 people. Mathematical analysis addressed the physiological characteristics of patients recorded at the time of hospital admission, as well as blood coagulation parameters and those reflecting the development of an inflammatory reaction. The analyzed parameters were categorized relative to the reference ranges of physiologically normal values. Correlation analysis was carried out using categorical data on the disease outcome. The algorithms for calculating statistical characteristics, as well as results visualization, were programmed in Python. When comparing patient groups, the significance of differences between the determined parameters was assessed using the Pearson’s χ 2 test with Yates’ correction. The study showed that the age over 50 and male sex can be considered risk factors for patients with COVID-19 pneumonia ( p < 0.05). The disease outcome was found to be significantly affected by cardiovascular pathologies ( p < 0.01) and to a lesser extent by diabetes mellitus ( p < 0.10). There were revealed maximal correlation coefficients between the oxygen saturation level (–0.43), as well as the breathing rate (0.43), and a fatal outcome of the disease. For patients over 50 years of age, oxygen saturation below 80% at the time of hospital admission turned out to be a marker of mortality. It was shown that D-dimer blood levels above 625 ng/mL in patients over 80 years of age correlated with mortal outcomes. No correlation was found between the C-reactive protein (CRP) level and the disease outcome. The effect of corticosteroids on the disease outcome was analyzed in patients with different CRP levels. It was found that, while using corticosteroids, the mortality rate in patients with CRP ≤ 12.5 mg/L is 2.7 times higher than in those with CRP > 12.5 mg/L ( p < 0.01). Thus, the use of adequate mathematical methods made it possible to define more precisely some mortality-associated physiological and biochemical indices in patients with COVID-19 pneumonia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Analysis of Some Physiological and Biochemical Indices in Patients with Covid-19 Pneumonia Using Mathematical Methods

Громов

Rogacheva

Barulina

et al. 2021

J Evol Biochem Phys

View full text Add to dashboard Cite

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“…В настоящее время АК терапия рекомендована при любой степени тяжести пневмонии при COVID-19 [30,31].…”

Section: Discussionunclassified

International register “Dynamics analysis of comorbidities in SARS-CoV-2 survivors” (AKTIV SARS-CoV-2): analysis of 1,000 patients

et al. 2020

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COVID-19 is a severe infection with high mortality. The concept of the disease has been shaped to a greater extent on the basis of large registers from the USA, Spain, Italy, and China. However, there is no information on the disease characteristics in Caucasian patients.Therefore, we created an international register with the estimated capacity of 5,000 patients — Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors (AKTIV SARS-CoV-2), which brought together professionals from the Russian Federation, Republic of Armenia, Republic of Kazakhstan, and Kyrgyz Republic. The article presents the first analysis of the register involving 1,003 patients. It was shown that the most significant difference of the Caucasian population was the higher effect of multimorbidity on the mortality risk vs other registers. More pronounced effect on mortality of such diseases as diabetes, obesity, hypertension, chronic kidney disease, and age over 60 years was also revealed.

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“…он не является специфичным маркером тромботических рисков и может учитываться только при отрицательном результате в качестве исключения тромбоза; 2. Рассматривать Д-димер как маркер воспаления и его возможную ассоциацию с неблагоприятным прогнозом смерти от COVID-19 только на госпитальном этапе [7,8];…”

Section: потенциальные тромботические риски после Covid-19unclassified

Rehabilitation after COVID-19. Resolution of the International Expert Council of the Eurasian Association of Therapists and the Russian Society of Cardiology

Arutyunov

Seferović²,

Бакулин

et al. 2021

Russ J Cardiol

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By the middle of 2021, the official global number of coronavirus disease 2019 (COVID-19) patients was close to 230 million, but the number accounting for asymptomatic patients was much higher. Consequences and rehabilitation after COVID-19 are of particular interest and raise many controversial and unresolved issues. On May 18, 2021, the Eurasian Association of Therapists organized an international panel of experts to analyze challenges associated with the post-COVID-19 period. This panel aimed to develop approaches to identify gaps in the discussed issues. This interdisciplinary team of leading experts reviewed the current literature and presented their data to formulate practical guidance on management of patients after COVID-19. The panel of experts also presented recommendations on how to implement the gained knowledge into health care practices.

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Cited by 11 publications

References 33 publications

Analysis of Some Physiological and Biochemical Indices in Patients with Covid-19 Pneumonia Using Mathematical Methods

Analysis of Some Physiological and Biochemical Indices in Patients with Covid-19 Pneumonia Using Mathematical Methods

International register “Dynamics analysis of comorbidities in SARS-CoV-2 survivors” (AKTIV SARS-CoV-2): analysis of 1,000 patients

Rehabilitation after COVID-19. Resolution of the International Expert Council of the Eurasian Association of Therapists and the Russian Society of Cardiology

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