International register “Dynamics analysis of comorbidities in SARS-CoV-2 survivors” (AKTIV SARS-CoV-2): analysis of 1,000 patients

Арутюнов, Г. П.; Тарловская, Е. И.; Арутюнов, А. Г.; Belenkov, Iu N; Konradi, Alexandra; Лопатин, Ю. М.; Терещенко, С Н; Ребров, А. П.; Чесникова, А. И.; Фомин, И. В.; Григорьева, Н. Ю.; Болдина, М. В.; Vaisberg, A. R.; Благонравова, А С; Makarova, Ekaterina; Шапошник, И. И.; Кузнецова, Т. Ю.; Malchikova, S. V.; Проценко, Д. Н.; Evzerikhina, A. V.; Petrova, Mirela; Демко, И. В.; Safonov, D; Айрапетян, Г. Г.; Галявич, А. С.; Ким, З. Ф.; Sugraliyev, Akhmetzhan; Nedogoda, S V; Tsoma, V. V.; Сайганов, С А; Gomonova, V. V.; Губарева, И. В.; Sarybaev, Akpay; Королева, Е. В.; Vilkova, O. E.; Фомина, И. Ю.; Пудова, И. А.; Soloveva, D. V.; Киселева, Н. В.; Зеляева, Н. В.; Куранова, И. М.; Погребецкая, В. А.; Muradova, F N; Бадина, О. Ю.; Kovalishena, O. V.; Galova, Elena A.; Пластинина, С С; Любавина, Н А; Везикова, Н. Н.; Levankova, V. I.; Иванова, С. Ю.; Ермилова, А. Н.; Мурадян, Р. Г.; Gostishchev, R. V.; Тихонова, Е. П.; Kuzmina, T. I.; Соловьева, И. А.; Крапошина, А. Ю.; Колядич, М. И.; Колчинская, Т. П.; Генкель, В. В.; Кузнецова, А. С.; Казаковцева, М. В.; Odegova, A. A.; Chudinovskikh, T. I.; Барамзина, С. В.; Rozanova, N A; Kerimova, A. Sh.; Кривошеина, Н А; Чухлова, С. Ю.; Levchenko, Artem; Авоян, О. Г.; Azarian, K. K.; Musaelian, Sh. N.; Avetisian, S A; Levin, Michael; Карпов, О. В.; Sokhova, F. M.; Бурыгина, Л А; Sheshina, T V; Tiurin, A A; Долгих, О. Ю.; Kazymova, E. V.; Константинов, Д. Ю.; Чумакова, О. А.; Kondriakova, O. V.; Шишков, К. Ю.; Fil, T. S.; Прокофьева, Н. А.; Konoval, M. P.; Simonov, A. A.; Bitieva, A. M.; Тростянецкая, Н А; Cholponbaeva, Meerim; Kerimbekova, Zh. B.; Duishobaev, Melis; Akunov, A. Ch.; Kushubakova, Nadira; Melnikov, E. S.; Ким, Е. С.; Щербаков, С. Ю.; Trofimov, D. A.; Evdokimov, D. S.; Айыпова, Д. А.; Duvanov, I. A.; Abdrakhmanova, Aigul; Aimakhanova, G. T.; Ospanova, Sh. O.; Dabylova, G. M.; Tursunova, A. T.; Каскаева, Д. С.; Туличев, А. А.; Ашина, Е. Ю.; Кордюкова, В. А.; Барышева, О. Ю.; Egorova, K E; Varlamova, D. D.; Kuprina, T. V.; Pakhomova, E. V.; Курчугина, Н. Ю.; Frolova, I A; Mazalov, K. V.; Subbotin, A. K.; Kamardina, N. A.; Заречнова, Н. В.; Мамутова, Э М; Smirnova, L. A.; Klimova, A V; Шахгильдян, Л. Д.; Tokmin, D. S.; Tupitsin, D. I.; Крюкова, Т. В.; Rakov, N. A.; Поляков, Д. С.

doi:10.15829/29/1560-4071-2020-4165

Cited by 9 publications

(2 citation statements)

References 30 publications

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“…Поиск наиболее часто встречающихся комбинаций из 2, 3, 4 и более заболеваний выявил абсолютное доминирование ССЗ во всех возможных вариантах. Наиболее неблагоприятной при сочетании двух сопутствующих заболеваний была комбинация АГ и ХСН, при сочетании трех заболеваний -комбинация АГ, ИБС, ХСН, а при сочетании четырех заболеваний -комбинация АГ, ИБС, ХСН и СД [8]. В работе HM Salah, et al проведена сравнительная оценка госпитализированных пациентов с острыми проявлениями COVID-19 и без анамнеза COVID-19 [27].…”

Section: Discussionunclassified

“…Доля случаев ССЗ в этом исследовании была несколько ниже, чем по данным работы Арутюнова Г. П. и др. (2022): АГ -59,4%, а ИБС -21,5% [8]. Однако в работе российских авторов частота некардиальной патологии была меньше, чем в зарубежных исследованиях (СД -18,3%, ХБП -7%).…”

Section: Discussionunclassified

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Outpatient-Polyclinic Register of the Multidisciplinary Medical Center (TERRA): general characteristics and first results

Lukyanov¹,

Andreenkо²,

Smirnov³

et al. 2023

Cardiovasc Ther Prev

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Aim. To describe the experience of creating the Outpatient-Polyclinic Register of the Multi-specialty Medical Center (TERRA) and the first results of the study.Material and methods. The TERRA registry included 32264 patients (age 44,0±15,3 years; 32,2% men) who applied to the multidisciplinary medical center from January 1, 2018 to December 31, 2021. Information from electronic outpatient records was evaluated. The data of patients with/without cardiovascular diseases (CVDs) in those who applied to general practitioners, cardiologists and other specialists, those with and without coronavirus disease 2019 (COVID-19) were compared.Results. There were 26,8% of patients with CVDs, while with ≥2 CVD — 8,1%, with CVD and/or chronic non-cardiac disease — 54,1%, their combination — 26%. Among those who consulted cardiologists, general practitioners and doctors of other specialties, hypertension was most often recorded — 64,8; 34,9 and 18,6%, coronary artery disease — 15,1, 6,2 and 3,2%, while from chronic non-cardiac diseases — diseases of the digestive system (64,4; 58,0 and 33,7%), kidneys (29,8; 24,9 and 13,2%), respiratory organs (28,4; 23,8 and 12,6%). The proportion of COVID-19 survivors was 8.2%, in patients with and without CVD — 14,8 and 5,1%, respectively (p<0,001). The proportion of CVD cases among survivors and non-survivors of COVID-19 was 58,0% and 25,2%, respectively (p<0,001). In addition, 88% of patients with CVDs consulted a cardiologist or general practitioner, of which 42% were observed by them together.Conclusion. The majority of patients at the multidisciplinary medical center had CVDs and chronic non-cardiac diseases, and more than a quarter had a combination of both. Patients with CVDs were more likely to have chronic non-cardiac diseases (2,2 times) and a history of COVID-19 (2,9 times). Among patients with a history of COVID-19, there was a higher proportion of cases of CVDs (by 2,3 times) and chronic non-cardiac pathology (by 1,8 times). Almost half of patients with CVD were observed jointly by a cardiologist and a general practitioner.

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Section: Discussionunclassified

Outpatient-Polyclinic Register of the Multidisciplinary Medical Center (TERRA): general characteristics and first results

Lukyanov¹,

Andreenkо²,

Smirnov³

et al. 2023

Cardiovasc Ther Prev

View full text Add to dashboard Cite

show abstract

An open-label multicenter observational study (registry) of patients recovered from coronavirus disease 2019 (COVID-19) with involvement of the cardiovascular system or with baseline severe cardiovascular diseases: rationale, design, and implications for clinical practice

et al. 2021

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The potential impact on cardiovascular morbidity and mortality have become one of the most important issues of the coronavirus disease 2019 (COVID-19) pandemic. COVID-19 may be associated with more frequent development of acute cardiovascular complications, while patients with established cardiovascular diseases are characterized by a higher risk of severe infection and adverse in-hospital outcomes. Due to the spread scale of the pandemic, understanding the long-term cardiovascular consequences of COVID-19 is of no less importance. Inability to extrapolate available international data to the Russian population has led to the initiation of a national multicenter study (registry) of patients recovered from COVID-19 and with concomitant involvement of the cardiovascular system or with baseline severe cardiovascular diseases. The article presents its rationale, design and implications of the results for clinical practice.

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Cytokine profile in hospitalized patients with COVID-19 of different severity

Grigoryeva¹,

Sinichkina

Petrova

et al. 2022

Russ J Cardiol

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Analysis of cytokine profile markers in conjunction with the clinical manifestations of coronavirus disease 2019 (COVID-19) can provide valuable information about the pathogenetic manifestations of the disease, and therefore, in the future, determine drugs that affect the cytokine storm and have an anti-inflammatory effect.Aim. To identify correlations between the parameters of the developed cytokine profile and the clinical course in hospitalized patients with COVID-19 of different severity.Material and methods. The study included 70 hospitalized patients with a confirmed diagnosis of COVID-19, with a mean age of 58 [50;69] years, including 40 men (57%) and 30 women (43%). The average lung involvement according to computed tomography (CT) at admission was CT-2 [1;3]. Peripheral venous blood was taken at admission, which averaged 7 [6; 8] days from the symptom onset. Standard biochemical parameters were studied, as well as 47 cytokines and chemokines using the Multiplex system (Merck KGaA, Darmstadt, Germany).Results. Correlations was found between the lung involvement degree and the level of IL-8 (r=0,31, p<0,05), IL-15 (r=0,35, p<0,05), IL-18 (r=0,31, p<0,05), MCP-1 (r=0,36, p<0,05), MIG (r=0,50, p<0,05), TNF-α (r=0,41, p<0,05). An inverse correlation was also found in the level of blood oxygen saturation with the same indicators as follows: IL-8 (r=-0,27, p<0,05), IL-15 (r=-0,34, p<0,05), IL-18 (r=-0,31, p<0,05), MCP-1 (r=-0,40, p<0,05), MIG (r=-0,56, p<0,05), TNF-α (r=-0,45, p<0,05). IL-6 levels were significantly elevated in patients with severe COVID-19 (CT3, CT4), while no increase in IL-6 was observed in patients with moderate disease (CT1, CT2). It is noteworthy that in patients with diabetes, the highest values of IL-12, IL-9 were recorded.Conclusion. Hyperinflammatory syndrome in severe COVID-19 is manifested by high levels of IL-6, MIG, MDC, MCP-1, M-CSF, TNF-α, β, IL-8, IL-18, IL-15. With the CT-1 and CT-2, an increase in only the level of IL-18, IL-8 is noted. The identified patterns prove and make it possible to explain a number of systemic inflammatory changes that occur with COVID-19.

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International register “Dynamics analysis of comorbidities in SARS-CoV-2 survivors” (AKTIV SARS-CoV-2): analysis of 1,000 patients

Cited by 9 publications

References 30 publications

Outpatient-Polyclinic Register of the Multidisciplinary Medical Center (TERRA): general characteristics and first results

Outpatient-Polyclinic Register of the Multidisciplinary Medical Center (TERRA): general characteristics and first results

An open-label multicenter observational study (registry) of patients recovered from coronavirus disease 2019 (COVID-19) with involvement of the cardiovascular system or with baseline severe cardiovascular diseases: rationale, design, and implications for clinical practice

Cytokine profile in hospitalized patients with COVID-19 of different severity

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