Rehabilitation after COVID-19. Resolution of the International Expert Council of the Eurasian Association of Therapists and the Russian Society of Cardiology

Arutyunov, A G; Seferović, Petar; Бакулин, И. Г.; Бакулина, Н. В.; Batyushin, M. M.; Болдина, М. В.; Krstačić, Goran; Macut, Djuro; Салухов, В. В.; Shimosawa, Tatsuo; Shustov, Valeriy V.; Tarlovskaya, E. I.; Vrtovec, Bojan; Wanner, Christoph; Айсанов, З. Р.; Arutyunov, G. P.; Авдеев, С. Н.; Babin, A. P.; Cattaneo, Marco; Чесникова, А. И.; Ezhov, M.; Kamilova, Umida; Козиолова, Н. А.; Lopatin, Yu. M.; Mitkovskaya, N. P.; Morais, João; Galstyan, Gagik Radikovich; Sarybaev, Akpay; Sugraliyev, Akhmetzhan; Yavelov, I. S.; Essaian, A. M.; Zolotovskaya, I. A.; Жангелова, Ш.Б.; Zyryanov, S. K.; Мельников, Е. С.; Bashkinov, R. A.; Shlyakhto, Evgeny

doi:10.15829/1560-4071-2021-4694

Cited by 12 publications

(3 citation statements)

References 28 publications

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“…Эти же жалобы, за исключением торакалгии и слабости, более активно предъявляли лица с ВВГ (но реже, чем больные СД2). Полученные данные позволят скорректировать программу реабилитации в постковидном периоде, поскольку пациентов с ВВГ и СД2 следует отнести к группе риска в отношении более длительных и устойчивых жалоб после инфекции [ 23 ]. К сожалению, из-за низкого отклика оказалось сложно отследить постковидную летальность, однако данные других исследований показывают, что СД являлся одним из ранних независимых предикторов 90-дневной смертности в выборке из 4643 пациентов с тяжелым течением COVID-19 [ 24 ], наличие СД2 у пациентов старше 60 лет увеличивало шанс смерти через 3 мес (ОШ 2,55; 95% ДИ 1,16–5,61; p=0,016) [ 25 ], а анализ более 100 тыс.…”

Section: Discussionunclassified

The impact of carbohydrate metabolism disorders on the early and long-term clinical outcomes of patients with COVID-19 according to the AKTIV and AKTIV 2 registries

Салухов

Arutyunov

Tarlovskaya

et al. 2023

Probl Endokrinol (Mosk)

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BACKGROUND: Numerous studies indicate a high incidence of various disorders of carbohydrate metabolism against the new coronavirus infection. These disorders aggravate the course of infection and increase mortality. Thereby, analysis of risk factors for unfavorable outcomes and assessment of the long-term consequences of COVID-19 in patients with impaired carbohydrate metabolism is of great importance.AIM: To investigate the association between carbohydrate metabolism disorders in COVID-19 patients and mortality, course of infection, long-term consequences, as well as to identify risk factors for an unfavorable disease course.MATERIALS AND METHODS: A retrospective analysis of data from the combined multicenter non-interventional real-world AKTIV and AKTIV 2 registries was performed. The sample included 9290 patients who had COVID-19 with varying severity from June 29, 2020, to November 29, 2020 (AKTIV) and from October 01, 2020, to March 30, 2021 (AKTIV 2). The patients were divided into 3 groups: Group 1 — patients with intact carbohydrate metabolism, n=6606; Group 2 — patients with newly diagnosed hyperglycemia (NDH), n=1073; Group 3 — patients with a history of type 2 diabetes mellitus (DM2), n=1611. The groups were assessed for clinical and laboratory parameters, comorbidities, mortality, carbohydrate metabolic status, and well-being during the infection and at 12 months.RESULTS: The prevalence of carbohydrate metabolism disorders (CMD) was 28,9%, with DM2 patients accounting for 17,3% and patients with newly diagnosed hyperglycemia (NDH) for 11,6%. The mortality rate of patients with hyperglycemia of any origin was 10.6%, which was significantly higher compared to patients without hyperglycemia (3,9%). The probability of lethal outcome increased 2,48-fold in the group of patients with DM2 and 2,04-fold in the group of patients with NDH. At the same time, the probability of a lethal outcome decreased 2,94-fold in patients without CMD. At 12 months, patients with CMD showed a significantly higher frequency and longer persistence of complaints. This trend was more pronounced in patients with DM2 than in those with NDH. Only 1,7% of patients from the NDH group had type 2 diabetes and were receiving oral hypoglycemic medications one year after the infection. A prognostic model was developed to determine the risk of lethal outcome. The model included such known predictors as concomitant ischemic heart disease, history of myocardial infarction or stroke, blood glucose level, and age.CONCLUSION: Carbohydrate metabolism disorders aggravate the course of COVID-19 and increase mortality. One year after infection, patients with DM2 and NDH were more likely to have symptoms typical for post-COVID syndrome, and NDH resolved in most cases after the infection.

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Section: Discussionunclassified

The impact of carbohydrate metabolism disorders on the early and long-term clinical outcomes of patients with COVID-19 according to the AKTIV and AKTIV 2 registries

Салухов

Arutyunov

Tarlovskaya

et al. 2023

Probl Endokrinol (Mosk)

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“…Тема реабилитации поднята в резолюции Международного совета экспертов Евразийской ассоциации терапевтов и Российского кардиологического общества, которая состоит из 16 пунктов и касается ведения пациента на постгоспитальном этапе и отсроченных рисков неблагоприятного прогноза ухудшения здоровья пациента [16] Часть публикаций -14 (7,1%) -описывают различные аспекты визуальной диагностики. Отмечено, что помимо изложения результатов, полученных с помощью традиционных методов компьютерной и магнитно-резонансной томографии, большое количество статей было посвящено анализу нарушений микроциркуляции у пациентов, перенесших COVID-19 различной степени тяжести.…”

Section: Key Messages What Is Already Known About the Subject?unclassified

Russian-language publication activity of medical researchers in during the COVID-19 pandemic: “post-COVID-19 syndrome”

Kim¹,

Drapkina²,

Rodionova³

2022

Cardiovasc Ther Prev

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Aim. To study the dynamics and pattern of publications in Russian on post-COVID-19 syndrome (PCS) in order to assess the completeness of information and identify medical specialties with its most active investigation in Russia.Material and methods. The search for publications was carried out in the database of the largest digital scientific library in Russia Elibrary.ru from February 1, 2021 to February 1, 2022. The study included publicly available medical publications on the consequences of coronavirus disease 2019 (COVID-19) in Russian. Publications were classified according to subject matter, study design, and evidence hierarchy. The data obtained is reflected using integers, percentages and graphs.Results. The study included 478 publications, of which 196 (41%) presented data from original studies, while 269 (56,3%) reflected the results of existing sources. Expert community documents accounted for 2,7%. In terms of study design, most of original studies described case series (37,2%) and individual case reports (22,4%). Casecontrol studies accounted for 20,4%, cross-sectional studies — 8,7%, prospective cohort studies — 3,6%, randomized clinical trials — 1,5%, and systematic reviews — 1%. In addition, 5,1% of publications were devoted to preclinical studies, mathematical models and various methodological aspects. By topic, the largest number of publications noted cardiovascular (12,2%) and neurological manifestations of PCS (12,2%). Furthermore, 23,5% of publications described the course of PCS in specific groups of patients, particular issues of COVID-19 consequences, and healthcare management problems. We also revealed that 11,7% of publications were devoted to general rehabilitation, 71% — to imaging diagnostics, 5,6% — to herd immunity to the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARSCoV-2), and 5,6% — to PCS features in children. The smallest number of publications considered mental (5,1%), gastroenterological (4,6%), pharmacological (4,6%), rheumatological (4%) and pulmonological aspects of PCS.Conclusion. The dynamics and pattern of publications on COVID-19 in Russian are generally consistent with global trends and reflect the natural consequences of the pandemic. This analysis of publications on PCS showed that the most in-demand specializations in this filed are cardiology, neurology, and rehabilitation.

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“…At the same time, this period after acute COVID-19 vary from several months to six months or even more. [2][3][4]. Cardiovascular manifestation in COVID-19 is diverse: acute myocardial infarction, myocarditis, stress-induced cardiomyopathy, nonischemic cardiomyopathy, coronary spasm [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Clinical and Morphological Characteristics of Covid-19 Associated Myocarditis

Bukeshov

Zhangelova

Kapsultanova

et al. 2022

IAM

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The article is devoted to the actual problem in the case of ongoing COVID-19 pandemic -the clinical and morphological characteristics of СOVID-19 associated myocarditis in conditions of non-widespread of this topic.The aim of the study is to study the clinical and morphological features of COVID-19 associated heart damage in deceased patients. The study included data from medical cards of inpatients of Almaty City cardiological center, as well as postmortem data of 12 patients (9 men and 3 women, average of age 65,6±13,8, 51-80 years), dead patients with a diagnosis of atherosclerosis-associated diseases. Pathological anatomical autopsy was performed at the Central Pathological Anatomical Department of Federal Health Institution "Central Medical and Sanitary Unit No. 1 of the Federal Medical and Biological Agency Hospital №1 Russia. Extrapolating data from the pathomorphological study of deceased patients, who had a history of coronavirus infection and died from circulatory system diseases, on autopsy it was found that SARS-Cov-2 infection led to the development of subacute/chronic myocarditis. Its clinical manifestations develop within 4-6 months or more than a year after acute COVID-19 in the form of myocardial infarction or progressive heart failure. The researchers also emphasize the extreme importance of performing autopsy studies of any nosology in combination with COVID-19, for subsequent clinical and morphological analysis, which provide invaluable opportunities to summarize each morphological manifestation of this infection to be further compared to clinical manifestations.Thus, at present, any unclear myocardial dysfunction requires serodiagnosis of a new coronavirus infection. SARS-Cov-2 infection can cause chronic nonbacterial lymphocytic thromboendocarditis with an autoimmune mechanism; as well as its combination with lymphocytic myocarditis. Research in this field still needs to be continued.

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Rehabilitation after COVID-19. Resolution of the International Expert Council of the Eurasian Association of Therapists and the Russian Society of Cardiology

Cited by 12 publications

References 28 publications

The impact of carbohydrate metabolism disorders on the early and long-term clinical outcomes of patients with COVID-19 according to the AKTIV and AKTIV 2 registries

The impact of carbohydrate metabolism disorders on the early and long-term clinical outcomes of patients with COVID-19 according to the AKTIV and AKTIV 2 registries

Russian-language publication activity of medical researchers in during the COVID-19 pandemic: “post-COVID-19 syndrome”

Clinical and Morphological Characteristics of Covid-19 Associated Myocarditis

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