2012
DOI: 10.1002/art.34512
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Use of serum procalcitonin to detect bacterial infection in patients with autoimmune diseases: A systematic review and meta‐analysis

Abstract: Conclusion. Procalcitonin has higher diagnostic value than CRP for the detection of bacterial sepsis in patients with autoimmune disease, and the test for procalcitonin is more specific than sensitive. A procalcitonin test is not recommended to be used in isolation as a rule-out tool.

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Cited by 66 publications
(34 citation statements)
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“…One particular inflammatory marker is procalcitonin (PCT), a 116 amino acid protein made in multiple sites of the body including liver and intestine. PCT has received much attention as a possible discriminatory serum marker in differentiating sepsis from systemic inflammatory response syndrome (SIRS) and bacterial sepsis from non-bacterial sepsis in multiple populations including cirrhotic patients [19][20][21][22][23][24][25][26][27] . Its significance in measuring ascitic fluid inflammation and/or infection, e.g., SBP, is less well characterized [28] .…”
Section: Introductionmentioning
confidence: 99%
“…One particular inflammatory marker is procalcitonin (PCT), a 116 amino acid protein made in multiple sites of the body including liver and intestine. PCT has received much attention as a possible discriminatory serum marker in differentiating sepsis from systemic inflammatory response syndrome (SIRS) and bacterial sepsis from non-bacterial sepsis in multiple populations including cirrhotic patients [19][20][21][22][23][24][25][26][27] . Its significance in measuring ascitic fluid inflammation and/or infection, e.g., SBP, is less well characterized [28] .…”
Section: Introductionmentioning
confidence: 99%
“…Так, J. Y. Wu и соавт. [17] проанали-зировали результаты 9 проспективных исследований, проведенных в период с 1997 по 2011 г., в которых со-поставляли СРБ и ПКТ в качестве маркеров бактери-альной инфекции у пациентов с аутоиммунными за-болеваниями. Авторы сделали вывод о более высокой суммарной специфичности ПКТ, составлявшей 0,90 (95 % ДИ 0,85-0,93), по сравнению с СРБ -0,56 (95 % ДИ 0,25-0,83), но его меньшей суммарной чувстви-тельности -0,75 (95 % ДИ 0,63-0,84) и 0,77 (95 % ДИ 0,67-0,85) соответственно.…”
Section: системные ревматические заболеванияunclassified
“…В ряде работ продемонстрировано, что СРБ уступает по чувствительности и специфичности ПКТ в диагности-ке ТБИ у лихорадящих детей при аутоиммунных заболе-ваниях [29] и нейтропении [30]. Кроме того, C. LuacesCubells и соавт.…”
Section: основные результаты исследованияunclassified