Use of Polyethylene Glycol in Investigations of Absorption of Fat

Vavrínková, H; Krondl, A

doi:10.1038/208293a0

Cited by 13 publications

(7 citation statements)

References 5 publications

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“…Secondly, the presence of PEG, at a concentration of 10 g/l diminishes the activity of the lipase (Vavrinkova and Krondl, 1965) by approximately 20% (personal findings). Thirdly, analysis of the intestinal liquid collected at points located approximately 55 cm and 85 cm distal from the ampulla of Vater indicated that an inactivation of pancreatic enzymes, notably the lipase (Table 4), had occurred in the intestine.…”

Section: Discussionmentioning

confidence: 96%

Effect of continuous jejunal perfusion of elemental and complex nutritional solutions on pancreatic enzyme secretion in human subjects.

Vison¹,

Hecketsweiler²,

Butel³

et al. 1978

Gut

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SUMMARY Pancreatic secretion of lipase and chymotrypsin in response to elemental diets and a crushed food homogenate was studied in normal subjects. The solutions were infused at constant flow rates at the ligament of Treitz with polyethylene glycol as a nonabsorbable marker. A triple lumen tube was used, enabling collection of secretions at 35 and 70 cm from the infusion point. The results show that a crushed food homogenate has a greater stimulative effect on pancreatic enzyme secretion than the elemental solutions and that this can be directly related to its greater nitrogen content. The osmolality of the infused solutions does not appear to be important. The relative merits of the solutions tested and total parental nutrition in reducing pancreatic enzyme secretion are discussed.

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Section: Discussionmentioning

confidence: 96%

Effect of continuous jejunal perfusion of elemental and complex nutritional solutions on pancreatic enzyme secretion in human subjects.

Vison¹,

Hecketsweiler²,

Butel³

et al. 1978

Gut

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“…Wiggins and Dawson (1961) showed that PEG being water soluble emptied more quickly from the stomach in the water-soluble phase than did the fat of a test meal. Vavfinkova and Krondl (1965) reported that PEG, at concentrations of 1 mg/ml or greater, inhibited lipase from hog pancreas and human duodenal juice in vitro and therefore PEG may not be suitable for the investigation of fat absorption. No increase in the faecal fatty acid excretion of patients taking PEG has been observed and after a suitable equilibration period PEG can be used to correct daily faecal fatty acid output with some success (Fig.…”

Section: Discussionmentioning

confidence: 99%

Polyethylene glycol 4000 as a continuously administered non-absorbable faecal marker for metabolic balance studies in human subjects

Wilkinson¹

1971

Gut

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SUMMARY The use of polyethylene glycol 4000 as a non-absorbable, continuously fed faecal marker is described. The intestinal handling and. transit of polyethylene glycol is compared with that of chromium sesquioxide and barium sulphate. Polyethylene glycol is an acceptable non-absorbable faecal marker for calcium, phosphorus, and fatty acids, and has several features which commend its use in preference to insoluble chromium sesquioxide and barium sulphate particularly when marking water-soluble dietary constituents.

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“…Estimates of fat absorption rates using both markers were in close agreement. Nevertheless, glycerol 3H-triether was shown in vivo not to be a pure oil phase marker [60] and PEG was reported to inhibit lipase activity from hog pancreas and human duodenal juice in vitro [58]. Another lipid-soluble non absorbable indicator, DC silicone fluid 703, a methylphenylpolysiloxane, has been used in the rat [48] but its suitability for perfusion studies in man has not yet been evaluated.…”

Section: Choice O F the Markermentioning

confidence: 99%