The relevance of the problem under study is due to the fact that at present the dependence of countries and regions on the world economy is increasing, there is a transition to an information society and a knowledge economy, there are changes in the way of life of people, which requires the use of new approaches to managing the development of regions and ensuring their competitiveness. The main priority task of the regional policy aimed at increasing the competitiveness of regions should be the development of their scientific, technological and innovative potential. To do this, it is necessary to find and effectively use tools for the strategic management of innovative development of regions. The purpose of the article is to develop recommendations for managing the innovative development of the region. The leading approach to problem research. The main research methods used within the framework of the article: analysis and synthesis of theoretical and legal materials, statistical analysis of data (indicators of dynamics, structure, incl.). Statistical indicators reflecting the innovative development of the region and other regions directly located in the south of Ukraine in the Black Sea region are considered. The article discusses the concepts of “strategic management”, “innovative development of the region”. Also, the tools of strategic management of innovative development at the regional level were considered, statistical indicators characterising the innovative development of the Odesa region were evaluated. Based on the results of the analysis, the problems of innovative development have been identified and ways to solve them have been developed. The transition of the Ukrainian economy to an innovative path of development requires from the regions special attention to the search and use of internal development reserves, based on the available scientific and intellectual potential. The existing approaches to the effectiveness of the instruments of state strategic management of the innovative development of the country's regions require revision. The priority ways of improving the management tools for regional innovative development are: the development of public consciousness, innovation and entrepreneurial culture; motivation of the population and entrepreneurship to actively innovate; improving the content of specialised training of management personnel for innovative development; algorithmicising the activities of regional leaders in managing regional innovative development. The implementation of the listed areas will contribute to innovative development, an increase in the efficiency of the regional economy, and an increase in the standard of living of the population. Practical significance: The materials of the article are of practical value for improving the strategic management of the innovative development of the region.