Use of mucosal immunization with porcine zona pellucida (PZP) in mice and rabbits

Martin, Brent J.; Suckow, Mark A.; Wolter, William R.; Berger, Thomas; Turner, John W.

doi:10.1016/j.anireprosci.2005.09.007

Cited by 5 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For conventional parenteral vaccination with porcine zona pellucida (PZP), although it can adequately induce a serum immune response in many studies, 75,76 it was very poor in inducing anti-PZP antibody in serum and reducing litter size by oral administration with combination PZP with alginate microsphere and cholera toxin B. 77 The results of this study indicate that PZP is not an effective antigen when combined with alginate microspheres for mucosal immunization. Delivery of naked DNA plasmids to mucosal surfaces usually produces little or no transfected epithelial cells and elicits a lower immune response.…”

Section: Microparticles and Nanoparticlesmentioning

confidence: 85%

“…This study demonstrates the feasibility of biodegradable microspheres encapsulating gamete antigen to stimulate SIgA in the reproductive tract. For conventional parenteral vaccination with porcine zona pellucida (PZP), although it can adequately induce a serum immune response in many studies, 75,76 it was very poor in inducing anti‐PZP antibody in serum and reducing litter size by oral administration with combination PZP with alginate microsphere and cholera toxin B 77 . The results of this study indicate that PZP is not an effective antigen when combined with alginate microspheres for mucosal immunization.…”

Section: Introductionmentioning

confidence: 84%

See 1 more Smart Citation

Oral immunocontraceptive vaccines: A novel approach for fertility control in wildlife

Yang

Zhou

Li³

et al. 2022

American J Rep Immunol

View full text Add to dashboard Cite

The overabundant populations of wildlife have caused many negative impacts, such as human‐wildlife conflicts and ecological degradation. The existing approaches like injectable immunocontraceptive vaccines and lethal methods have limitations in many aspects, which has prompted the advancement of oral immunocontraceptive vaccine. There is growing interest in oral immunocontraceptive vaccines for reasons including high immunization coverage, easier administration, frequent boosting, the ability to induce systemic and mucosal immune responses, and cost‐effectiveness. Delivery systems have been developed to protect oral antigens and enhance the immunogenicity, including live vectors, microparticles and nanoparticles, bacterial ghosts, and mucosal adjuvants. However, currently, no effective oral immunocontraceptive vaccine is available for field trials because of the enormous development challenges, including biological and physicochemical barriers of the gastrointestinal tract, mucosal tolerance, pre‐existing immunity, antigen residence time in the small intestine, species specificity and other safety issues. To overcome these challenges, this article summarizes achievements in delivery systems and contraceptive antigens in oral immunocontraceptive vaccines and explores the potential barriers for future vaccine design and application.

show abstract

Section: Microparticles and Nanoparticlesmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 84%

Oral immunocontraceptive vaccines: A novel approach for fertility control in wildlife

Yang

Zhou

Li³

et al. 2022

American J Rep Immunol

View full text Add to dashboard Cite

show abstract

“…These molecules are functional proteins that activate signals in cells during embryo implantation. Functional proteins that regulate certain biological processes are known as regulatory proteins [5,6]. Regulatory proteins secreted during implantation can be classified as signaling proteins [7,8].…”

Section: Introductionmentioning

confidence: 99%

Regulation of Integrin β3 Protein Secretion on Implantation Embryo of Mouse (Mus musculus L.) Induced by Oil Atsiri of Purple Nutsedge Tubers (Cyperus rotundus L.)

Busman

Sutyarso

Farisi

et al. 2019

ARRB

View full text Add to dashboard Cite

Aims: This study aims to determine the regulation of β3 integrin protein in the period of embryo implantation after being induced by oil atsiri of purple nutsedge tubers. Study Design: The study employed a completely randomised design using four concentration levels repeated six times. Place and Duration of Study: Organic Chemistry Laboratory and Zoology Laboratory of Faculty of Mathematics and Natural Sciences University of Lampung, between June 2015 and April 2016. Methodology: This study used mouse as experimental animals with 24 female mouse, then mated with male mouse with a ratio (1 female: 1 male). After the vaginal plug was found in female mouse, then the essential oil of purple nutsedge tubers was induced orally (force-fed) according to the treatment dose. Each 6 female mice were grouped as a control group, and 3 treatment groups, consisting of controls (C) = 0.4 ml aquabides, treatment 1 (T1) = 4.5 mg/40g body weight, treatment 2 (T2) = 45 mg/40g body weight, and treatment 3 (T3) = 135 mg/40g body weight. After the one way Anova test, Ho is rejected, meaning there are significant differences and the analysis is continued with multiple comparison tests, in this case the Least Significant Difference (LSD) test is used. Results: The results shown that the induction of essential oils of purple nutsedge tubers can reduce the level of β3 integrin protein in uterus mouse significantly. Conclusion: It is suggested essential oil of purple nutsedge tubers has potential decrease and can reduce the level of β3 integrin protein in uterus mouse during the period of embryo implantation.

show abstract

Delivery of plant-made vaccines and therapeutics

Pelosi¹,

Shepherd²,

Walmsley³

2012

Biotechnology Advances

View full text Add to dashboard Cite

Use of mucosal immunization with porcine zona pellucida (PZP) in mice and rabbits

Cited by 5 publications

References 22 publications

Oral immunocontraceptive vaccines: A novel approach for fertility control in wildlife

Oral immunocontraceptive vaccines: A novel approach for fertility control in wildlife

Regulation of Integrin β3 Protein Secretion on Implantation Embryo of Mouse (Mus musculus L.) Induced by Oil Atsiri of Purple Nutsedge Tubers (Cyperus rotundus L.)

Delivery of plant-made vaccines and therapeutics

Contact Info

Product

Resources

About