Use of Midazolam as an Induction Agent: Comparison With Thiopentone

Jensen, Svend Borup; Schou-Olesen, A.; Hüttel, M.

doi:10.1016/s0007-0912(17)46813-9

Cited by 29 publications

(11 citation statements)

References 5 publications

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“…The incidence was much less in midazolam and in co-induction group. The incidence of midazolam-induced apnoea in literature is more than we observed (18 to 78%) 12 .…”

Section: Discussioncontrasting

confidence: 46%

Midazolam and Thiopentone as Co-Induction

Rahman

Hassan

Islam

2009

j Bangladesh Soc Anaesthesiologists

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“…The incidence was much less in midazolam and in co-induction group. The incidence of midazolam-induced apnoea in literature is more than we observed (18 to 78%) 12 .…”

Section: Discussioncontrasting

confidence: 46%

Midazolam and Thiopentone as Co-Induction

Rahman

Hassan

Islam

2009

j Bangladesh Soc Anaesthesiologists

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“…Arterial blood pressure and systemic vascular resistance increased after 3 min following thiopentone administration and decreased following midazolam administration 156 [II]. On the other hand, no differences in arterial blood pressure and heart rate, 157 stroke volume, cardiac output or systemic vascular resistance 158 were demonstrated in these studies [II]. Table 8 Recommendations for hypnotic drugs considering the haemodynamic system.…”

Section: Thiopentone and Midazolammentioning

confidence: 99%

Scandinavian clinical practice guidelines on general anaesthesia for emergency situations

Jensen

Callesen

Hagemo

et al. 2010

Acta Anaesthesiol Scand

115

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Emergency patients need special considerations and the number and severity of complications from general anaesthesia can be higher than during scheduled procedures. Guidelines are therefore needed. The Clinical Practice Committee of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine appointed a working group to develop guidelines based on literature searches to assess evidence, and a consensus meeting was held. Consensus opinion was used in the many topics where high‐grade evidence was unavailable. The recommendations include the following: anaesthesia for emergency patients should be given by, or under very close supervision by, experienced anaesthesiologists. Problems with the airway and the circulation must be anticipated. The risk of aspiration must be judged for each patient. Pre‐operative gastric emptying is rarely indicated. For pre‐oxygenation, either tidal volume breathing for 3 min or eight deep breaths over 60 s and oxygen flow 10 l/min should be used. Pre‐oxygenation in the obese patients should be performed in the head‐up position. The use of cricoid pressure is not considered mandatory, but can be used on individual judgement. The hypnotic drug has a minor influence on intubation conditions, and should be chosen on other grounds. Ketamine should be considered in haemodynamically compromised patients. Opioids may be used to reduce the stress response following intubation. For optimal intubation conditions, succinylcholine 1–1.5 mg/kg is preferred. Outside the operation room, rapid sequence intubation is also considered the safest method. For all patients, precautions to avoid aspiration and other complications must also be considered at the end of anaesthesia.

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“…16 Nevertheless, the use of midazolam has produced haemodynamically stable anaesthesia in patients for heart surgeryl7 and in healthy subjects. 18 In our investigation, the QF interval remained constant during the induction of anaesthesia, an indication that ventricular performance was unaffected by either drug at the concentrations used. Apparently, the benzodiazepines produced little cardiac depression in the sick patients in our study which supports previous work which showed that systolic time intervals do not change during anaesthetic induction with midazolam in a healthy population.…”

Section: Discussionmentioning

confidence: 48%

A Comparison of Midazolam and Diazepam for Induction of Anaesthesia in High-Risk Patients

1987

Anaesth Intensive Care

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Fifty ASA Class JII patients were divided randomly into two equal groups for induction of anaesthesia with diazepam 0.25 mg / kg, or midazolam 0.15 mg / kg. All subjects were premedicated with a narcotic and monitored by ECG, radial arterial catheter and a spirometer for measurement of minute ventilation. The QF interval (time period from the Q wave of the ECG to thefoot of the radial artery pulse), mean arterial pressure, heart rate and minute ventilation were recorded before, during and immediately after the induction of anaesthesia. Although mean arterial pressure fell slightly (6%) following midazolam, all other cardiovascular variables were stable in both groups. Minute ventilation was depressed to 70% of control by both drugs and nearly onehalf the diazepam patients complained of pain on injection compared with only,one midazolam patient. These data suggest that midazolam is a reasonable alternative to diazepam for induction of anaesthesia in the high-risk patient.

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Use of Midazolam as an Induction Agent: Comparison With Thiopentone

Cited by 29 publications

References 5 publications

Midazolam and Thiopentone as Co-Induction

Midazolam and Thiopentone as Co-Induction

Scandinavian clinical practice guidelines on general anaesthesia for emergency situations

A Comparison of Midazolam and Diazepam for Induction of Anaesthesia in High-Risk Patients

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