Use of Indirect Microhemagglutination Test with Stable Sensitized Red Cells in the Detection of Horse Protein Allergy

Ring, Johannes; Enders, B.; Seiler, F. R.; Seifert, J.; Steininger, J.; Brendel, W.

doi:10.1159/000231486

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…The indirect microhemagglutination test was performed according to a previously described method [41],…”

Section: Indirect Hemagglutination Testmentioning

confidence: 99%

Immunosuppression with Antilymphocyte Globulin (ALG) in the Treatment of Ophthalmic Disorders

Ring¹,

Dechant²,

Seifert³

et al. 1978

Ophthalmic Res

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Immunosuppression with antilymphocyte globulin (ALG) was administered to 13 patients suffering from ophthalmic diseases. These included 4 with sympathetic ophthalmia, 3 with chronic generalized uveitis, 1 with necrotizing scleritis, 3 with corneal transplantation and 2 with combined corneal and scleral transplants. There was significant improvement in the patients with sympathetic ophthalmia and uveitis when ALG treatment was started early enough, i.e., as long as inflammatory processes were demonstrable. The results achieved in patients given corneal transplants were less convincing in the final outcome, although 3 patients – 2 had rejected previous corneal grafts within weeks – tolerated their corneas for several months after ALG treatment. It was not possible to reverse opacification occurring during corneal graft failure by ALG

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“…The indirect microhemagglutination test was performed according to a previously described method [41],…”

Section: Indirect Hemagglutination Testmentioning

confidence: 99%

Immunosuppression with Antilymphocyte Globulin (ALG) in the Treatment of Ophthalmic Disorders

Ring¹,

Dechant²,

Seifert³

et al. 1978

Ophthalmic Res

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Elimination and organ distribution of intravenously administered allogeneic and xenogeneic IgG modifications (Standard IgG, F(ab′)2-fragments andβ-propiolactone treated IgG) in dogs

Ring¹,

Duswald²,

Bachmann³

et al. 1978

Res. Exp. Med.

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Dog IgG was produced by fractionation procedures used for the production of clinically used i.v. gammaglobulins. Chemical modification of dog IgG was done by pepsin or beta-propiolactone treatment. The intravascular half-life of beta-propiolactone IgG was 8.5 +/- 2.1 days compared to 4.5 +/- 1.6 days of pepsin treated IgG. Tissue concentrations of radioactive labelled beta-propiolactone IgG were generally higher than of pepsin digested IgG. Pepsin treated Igg was degraded to a significantly higher extent (26% of the administered radioactivity was bound to fragments smaller than 6000 MW after three days) than beta-propiolactone IgG (9% fragments after the same interval, P less than 0.001). It is concluded that the short intravascular half-life of pepsin IgG cannot be explained by increased extravascular filling, but is due to rapid degradation and excretion via the kidneys. There was no obvious difference in elimination and organ distribution between standard and beta-propiolactone IgG.

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High incidence of horse serum protein allergy in various autoimmune disorders

Ring¹,

Seifert²,

Brendel³

1977

Journal of Allergy and Clinical Immunology

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Use of Indirect Microhemagglutination Test with Stable Sensitized Red Cells in the Detection of Horse Protein Allergy

Cited by 3 publications

References 6 publications

Immunosuppression with Antilymphocyte Globulin (ALG) in the Treatment of Ophthalmic Disorders

Immunosuppression with Antilymphocyte Globulin (ALG) in the Treatment of Ophthalmic Disorders

Elimination and organ distribution of intravenously administered allogeneic and xenogeneic IgG modifications (Standard IgG, F(ab′)2-fragments andβ-propiolactone treated IgG) in dogs

High incidence of horse serum protein allergy in various autoimmune disorders

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