High incidence of horse serum protein allergy in various autoimmune disorders

Ring, Johannes; Seifert, J.; Brendel, W.

doi:10.1016/0091-6749(77)90148-8

Cited by 5 publications

(6 citation statements)

References 19 publications

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“…It is used for blood flow imaging in the heart, liver and brain [4,18,19] and may be used in veterinary science and medicine in the future. However, Optison ® also has the possibility of causing anaphylaxis in animals since a major component of this compound is human albumin microspheres [9,13]. In this paper, we report two dogs with an AR to Optison ® out of a group of 26 dogs given intravenous injections of this agent for another purpose [21].…”

mentioning

confidence: 98%

“…Major cardiovascular responses to AR are an increase in heart rate, systemic hypotension and a fall in Q . T and DO 2 to tissues [3,9,15]. Potential pulmonary responses are a rise in PVR, bronchoconstriction and sometimes pulmonary edema [1,6,8,14].…”

Section: A /Qmentioning

confidence: 99%

“…One of the clinical disadvantages of using these materials is unpredictable anaphylactoid responses (AR), which are caused by non-immunologic mechanisms [9,13]. Optison ® (Mallinckrodt, Inc., CA, U.S.A.) is a new contrast agent for ultrasonography in human medicine.…”

mentioning

confidence: 99%

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Anaphylactoid Response to Optison and Its Effects on Pulmonary Function in Two Dogs

Yamaya

Niizeki²,

Kim³

et al. 2004

The Journal of Veterinary Medical Science

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ABSTRACT. Two of 26 anesthetized dogs given the cardiac echo-enhancing agent Optison ® showed anaphylactoid responses (AR) related to the human albumin component of this agent. The episodes of AR were self-limited, and could be reproduced by human albumin injection alone. Gas exchange was maintained by mechanical ventilation and 5 cm H 2 O PEEP, and dispersion of ventilation remained normal during AR despite severe hypotension. We suggest that: (1) pre-screening by measuring blood pressure response to intravenous injection of small doses of Optison ® , and (2) availability of access to the airway in addition to emergency agents may be prudent preventive measures when Optison ® is used in animals to enhance echocardiographic imaging.KEY WORDS: gas exchange, human albumin, hypotension.

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mentioning

confidence: 98%

Section: A /Qmentioning

confidence: 99%

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Anaphylactoid Response to Optison and Its Effects on Pulmonary Function in Two Dogs

Yamaya

Niizeki²,

Kim³

et al. 2004

The Journal of Veterinary Medical Science

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“…The horse genome sequence will also assist trait mapping of specific diseases within modern breeds of horses and contribute to a better understanding of medical conditions such as influenza, arthritis and allergies that are shared by horses and humans (Ring et al 1977; Livesay et al 1987; Dolvik & Klemetsdal 1996). Many drugs are used to improve health and treat disease for both species and given the roles of CES in drug metabolism (Redinbo and Potter 2005), lung physiology (Ruppert et al 2006) and xenobiotic, insecticide, lipid and cholesterol metabolism (see Imai 2006), studies of the genetics and biochemistry of horse CES will contribute to an improved understanding of the contribution of genetics to these important metabolic processes in the horse.…”

Section: Discussionmentioning

confidence: 99%

Horse carboxylesterases: Evidence for six CES1 and four families of CES genes on chromosome 3

Holmes

Cox

VandeBerg

2009

Comparative Biochemistry and Physiology Part D: Genomics and Pr

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Carboxylesterases (CES) are responsible for the detoxification of a wide range of drugs and xenobiotics, and may contribute to cholesterol, fatty acid and lung surfactant metabolism. In this study, in silico methods were used to predict the amino acid sequences, secondary and tertiary structures, and gene locations for horse CES genes and encoded proteins, using data from the recently completed horse genome project. Evidence was obtained for six CES1 genes closely localised on horse chromosome 3, for which the predicted CES1 gene products are ≥74% identical. The horse genome also showed evidence for three other CES gene classes: CES5, located in tandem with the CES1 gene cluster; and CES2 and CES3, located more than 9 million base pairs downstream on chromosome 3. Horse CES2, CES3 and CES5 gene products shared 42-46% identity with each other, and with the CES1 protein subunits. Sequence alignments of these enzymes demonstrated key enzyme and family specific CES protein sequences reported for human CES1, CES2, CES3 and CES5. In addition, predicted secondary and tertiary structures for horse CES1, CES2, CES3 and CES5 subunits showed extensive conservation with human CES1. Phylogenetic analyses demonstrated the relationships and potential evolutionary origins of the horse CES sequences with previously reported sequences for human and other mammalian CES gene products. Several CES1 gene duplication events have apparently occurred following the appearance of the 'dawn' horse ~ 55 million years ago.

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“…purposes. Though the T helper-specific human T4 antigen had already been described by 1979(Reinherz et al 1979, a systemic study of its usefulness as target for immuno therapies became possible only when a monoclonal antibody against its murine homoiogue, L3T4, was made available (Dialynas et al 1983). As elsewhere reported in this volume, CD4 antibodies have become a major analytical and therapeutic tool to dissect and influence the immune response in vivo.…”

Section: Introductionmentioning

confidence: 99%

From Antilymphocyte Serum to Therapeutic Monoclonal Antibodies: First Experiences with a Chimeric CD4 Antibody in the Treatment of Autoimmune Disease

Riethmuuller¹,

Rieber²,

Kiefersauer³

et al. 1992

Immunological Reviews

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High incidence of horse serum protein allergy in various autoimmune disorders

Cited by 5 publications

References 19 publications

Anaphylactoid Response to Optison and Its Effects on Pulmonary Function in Two Dogs

Anaphylactoid Response to Optison and Its Effects on Pulmonary Function in Two Dogs

Horse carboxylesterases: Evidence for six CES1 and four families of CES genes on chromosome 3

From Antilymphocyte Serum to Therapeutic Monoclonal Antibodies: First Experiences with a Chimeric CD4 Antibody in the Treatment of Autoimmune Disease

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