1978
DOI: 10.1007/bf01851492
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Elimination and organ distribution of intravenously administered allogeneic and xenogeneic IgG modifications (Standard IgG, F(ab′)2-fragments andβ-propiolactone treated IgG) in dogs

Abstract: Dog IgG was produced by fractionation procedures used for the production of clinically used i.v. gammaglobulins. Chemical modification of dog IgG was done by pepsin or beta-propiolactone treatment. The intravascular half-life of beta-propiolactone IgG was 8.5 +/- 2.1 days compared to 4.5 +/- 1.6 days of pepsin treated IgG. Tissue concentrations of radioactive labelled beta-propiolactone IgG were generally higher than of pepsin digested IgG. Pepsin treated Igg was degraded to a significantly higher extent (26% … Show more

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Cited by 4 publications
(1 citation statement)
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“…The t 1/2 of GPIba-Ig/2V was also shorter than the t 1/2 of lesser potent GPIba-Ig/1V. In addition, the t 1/2 of GPIba-Ig/2V of 57 h in mice, of 84 h in rats and of 48 h in dogs were comparatively shorter to the t 1/2 of human IgG or other recombinant Fc chimeric proteins in these lab animals (4Y6, 13,14).…”
Section: Discussionmentioning
confidence: 82%
“…The t 1/2 of GPIba-Ig/2V was also shorter than the t 1/2 of lesser potent GPIba-Ig/1V. In addition, the t 1/2 of GPIba-Ig/2V of 57 h in mice, of 84 h in rats and of 48 h in dogs were comparatively shorter to the t 1/2 of human IgG or other recombinant Fc chimeric proteins in these lab animals (4Y6, 13,14).…”
Section: Discussionmentioning
confidence: 82%