Use of graphene-based materials as carriers of bioactive agents

Lai, Wing‐Fu; Wong, Wing‐Tak

doi:10.1016/j.ajps.2020.11.004

Cited by 68 publications

(23 citation statements)

References 117 publications

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“…The capacitance of MXene-based devices can be further enhanced by producing its composites with other materials such as reduced graphene oxide, metal oxides, and conducting polymers [41,42]. Scientists are also attempting to use certain pristine metal oxides and their composites with 2D materials in various biological applications [43][44][45][46][47].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, Photocatalysis, and Antibacterial Study of WO3, MXene and WO3/MXene Nanocomposite

et al. 2022

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Tungsten oxide (WO3), MXene, and an WO3/MXene nanocomposite were synthesized to study their photocatalytic and biological applications. Tungsten oxide was synthesized by an easy and cost-effective hydrothermal method, and its composite with MXene was prepared through the sonication method. The synthesized tungsten oxide, MXene, and its composite were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), Fourier transform infrared (FTIR), energy-dispersive X-ray analysis (EDX), and Brunauer–Emmett–Teller (BET) for their structural, morphological, spectral, elemental and surface area analysis, respectively. The crystallite size of WO3 calculated from XRD was ~10 nm, the particle size of WO3 was 130 nm, and the average thickness of MXene layers was 175 nm, which was calculated from FESEM. The photocatalytic activity of as-synthesized samples was carried out for the degradation of methylene blue under solar radiation, MXene, the WO3/MXene composite, and WO3 exhibited 54%, 89%, and 99% photocatalytic degradation, respectively. WO3 showed maximal degradation ability; by adding WO3 to MXene, the degradation ability of MXene was enhanced. Studies on antibacterial activity demonstrated that these samples are good antibacterial agents against positive strains, and their antibacterial activity against negative strains depends upon their concentration. Against positive strains, the WO3/MXene composite’s inhibition zone was at 7 mm, while it became 9 mm upon increasing the concentration. This study proves that WO3, MXene, and the WO3/MXene nanocomposite could be used in biological and environmental applications.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, Photocatalysis, and Antibacterial Study of WO3, MXene and WO3/MXene Nanocomposite

et al. 2022

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“…Given that the biosafety of PTA is also a critical concern, the biomimetic materials such as PEG, lipids and proteins are applied to modify the PTA, making it more biocompatible [15] . Secondly, since some PTAs like GO could serve as carriers with extraordinary loading efficiency due to their physicochemical properties, the functional elements could be conjugated through covalent or non-covalent conjugation [ 128 , 129 ]. The integrated nanomedicine for mPTT ought to possess appropriate diameter, charge, morphology, targeting and penetrating ligand for sufficient tumor accumulation and deeply intratumoral distribution of drugs for magnified therapeutic benefits and reduced side effects [130] .…”

Section: Discussionmentioning

confidence: 99%

Nanomedicine potentiates mild photothermal therapy for tumor ablation

Jiang

Cheng

et al. 2021

Asian Journal of Pharmaceutical Sciences

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The booming photothermal therapy (PTT) has achieved great progress in non-invasive oncotherapy, and paves a novel way for clinical oncotherapy. Of note, mild temperature PTT (mPTT) of 42–45 °C could avoid treatment bottleneck of the traditional PTT, including nonspecific injury to normal tissues, vasculature and host antitumor immunity. However, cancer cells can resist mPTT via heat shock response and autophagy, thus leading to insufficient mPTT monotherapy to ablate tumor. To overcome the deficient antitumor efficacy caused by thermo-resistance of cancer cells and mono mPTT, synergistic therapies towards cancer cells have been conducted with mPTT. This review summarizes the recent advances in nanomedicine-potentiated mPTT for cancer treatment, including strategies for enhanced single-mode mPTT and mPTT plus synergistic therapies. Moreover, challenges and prospects for clinical translation of nanomedicine-potentiated mPTT are discussed.

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“…The application of bioactive GQD-based polymer composite on other non-viral vectors seems to be less common than using bioactive GQD-based polymer composites as drug delivery agents. Due to the sp2 hybridized structure and π-stacking in bioactive GQDs-based polymer composite systems, the possibility of drug loading in bioactive GQD-based polymer composite systems is higher than in other nanoparticle-based drug delivery systems [ 252 , 253 , 254 , 255 , 256 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Bioactive Graphene Quantum Dots Based Polymer Composite for Biomedical Applications

et al. 2022

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Today, nanomedicine seeks to develop new polymer composites to overcome current problems in diagnosing and treating common diseases, especially cancer. To achieve this goal, research on polymer composites has expanded so that, in recent years, interdisciplinary collaborations between scientists have been expanding day by day. The synthesis and applications of bioactive GQD-based polymer composites have been investigated in medicine and biomedicine. Bioactive GQD-based polymer composites have a special role as drug delivery carriers. Bioactive GQDs are one of the newcomers to the list of carbon-based nanomaterials. In addition, the antibacterial and anti-diabetic potentials of bioactive GQDs are already known. Due to their highly specific surface properties, π-π aggregation, and hydrophobic interactions, bioactive GQD-based polymer composites have a high drug loading capacity, and, in case of proper correction, can be used as an excellent option for the release of anticancer drugs, gene carriers, biosensors, bioimaging, antibacterial applications, cell culture, and tissue engineering. In this paper, we summarize recent advances in using bioactive GQD-based polymer composites in drug delivery, gene delivery, thermal therapy, thermodynamic therapy, bioimaging, tissue engineering, bioactive GQD synthesis, and GQD green resuscitation, in addition to examining GQD-based polymer composites.

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Use of graphene-based materials as carriers of bioactive agents

Cited by 68 publications

References 117 publications

Synthesis, Characterization, Photocatalysis, and Antibacterial Study of WO3, MXene and WO3/MXene Nanocomposite

Synthesis, Characterization, Photocatalysis, and Antibacterial Study of WO3, MXene and WO3/MXene Nanocomposite

Nanomedicine potentiates mild photothermal therapy for tumor ablation

Bioactive Graphene Quantum Dots Based Polymer Composite for Biomedical Applications

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