Use of fibrin glue in preventing urethrocutaneous fistula after hypospadias repair

Gopal, S. C.; Gangopadhyay, A. N.; Mohan, T. Vittal; Upadhyaya, Vijai D.; Pandey, Anand; Upadhyaya, Ashish; Gupta, Dinesh

doi:10.1016/j.jpedsurg.2008.04.022

Cited by 37 publications

(36 citation statements)

References 15 publications

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“…The authors clearly demonstrated a shortened overall operative time and a decreased occurrence of the early postoperative leakage. Others however have pointed out that the application of glue in hypospadias repair does not completely eliminate fistula formation, even though it seems that it may minimizes the incidence of fistula formation and flap dehiscence [11,12]. …”

Section: Discussionmentioning

confidence: 99%

“…Some authors have demonstrated that covering the first suture line with single or double dartos flap or spongioplasty may decrease the incidence of fistula development [5,6,7,8,9]. Others have demonstrated some benefits with the use of fibrin glue as a sealant for urethrocutaneous fistula prevention after hypospadias repair and for the closure of fistulas [10,11,12]. However fibrin sealants from a single-donor or multiple donors have some risks of HCV, HBV or HIV contamination, may sometimes lead to a severe allergic reaction, and are also expensive [13,14].…”

Section: Introductionmentioning

confidence: 99%

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Use of BioGlue Surgical Adhesive in Hypospadias Repair

Kocherov¹,

Lev²,

Chertin³

2014

Current Urology

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Purpose: To prospectively evaluate the efficacy of albumin glutaraldehyde tissue adhesive (BioGlue) in the surgical treatment of patients with hypospadias. Materials and Methods: Two groups of 20 patients each who underwent hypospadias repair were included in the study. In the first group we utilized BioGlue as an additional protective layer to the suture line of the neo-urethra, while patients in the second group were operated on utilizing a routine surgical technique. Results: There were no statistical differences between patients from the 2 groups in terms of surgical complications. Urethrocutaneous fistula was revealed in 4 (20%) patients after repair with BioGlue and in 3 (15%) patients from the control group (p = 0.686), suture line breakdown in 4 (20%) and in 1 (5%) patients (p = 0.478), meatal stenosis in 1 (5%) and in 1 (5%) patient (p = 1). Furthermore more patients in the BioGlue group (n = 12, 60%) demonstrated poor cosmetic results compared to the control group where most patients - 19 (95%) had acceptable cosmetic outcomes (p = 0.007). Conclusions: Our data showed no benefits of BioGlue use in hypospadias repair.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Use of BioGlue Surgical Adhesive in Hypospadias Repair

Kocherov¹,

Lev²,

Chertin³

2014

Current Urology

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“…They found out that the rate of fistula formation, postoperative edema and duration of hospitalization were all reduced using Tisseel, the commercially available fibrin glue, on suture lines [5]. Other studies have confirmed the reduction in the incidence of postoperative urethrocutaneous fistula using fibrin glue [17,18]. Fibrin sealants can also be useful in complex anterior and posterior urethral surgeries, when skin or buccal mucosal grafts are used.…”

Section: Discussionmentioning

confidence: 99%

“…Fistulae developed in six patients (10%) with hypospadias in whom fibrin glue was also used, while 19 (32%) of those cases without it developed a fistula postoperatively [18].…”

Section: Discussionmentioning

confidence: 99%

Single-donor fibrin sealant for repair of urethrocutaneous fistulae following multiple hypospadias and epispadias repairs

Kajbafzadeh

Abolghasemi

Eshghi

et al. 2011

Journal of Pediatric Urology

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“…1 Some reports have shown that application of fibrin glue to the repair of hypospadias can greatly decrease the incidence of fistula formation. 1 In addition, using fibrin glue as a transport and support matrix seeded with urothelial cells (UCs) successfully created an artificial urethra. 2 Fibrin glue was used in cardiovascular surgery as a hemostatic agent against diffuse bleeding from friable tissue and along suture lines.…”

Section: Introductionmentioning

confidence: 99%