Use of BioGlue Surgical Adhesive in Hypospadias Repair

Abstract

Purpose: To prospectively evaluate the efficacy of albumin glutaraldehyde tissue adhesive (BioGlue) in the surgical treatment of patients with hypospadias. Materials and Methods: Two groups of 20 patients each who underwent hypospadias repair were included in the study. In the first group we utilized BioGlue as an additional protective layer to the suture line of the neo-urethra, while patients in the second group were operated on utilizing a routine surgical technique. Results: There were no statistical differences between patients from the 2 groups in terms of surgical complications. Urethrocutaneous fistula was revealed in 4 (20%) patients after repair with BioGlue and in 3 (15%) patients from the control group (p = 0.686), suture line breakdown in 4 (20%) and in 1 (5%) patients (p = 0.478), meatal stenosis in 1 (5%) and in 1 (5%) patient (p = 1). Furthermore more patients in the BioGlue group (n = 12, 60%) demonstrated poor cosmetic results compared to the control group where most patients - 19 (95%) had acceptable cosmetic outcomes (p = 0.007). Conclusions: Our data showed no benefits of BioGlue use in hypospadias repair.

Efficacy of fibrin sealant as waterproof cover in improving outcome in hypospadias surgery

“…This is in contrast to observations made in recent studies. [ 21 22 23 25 ] However, similar to the observations by Ambriz-González et al ., we also observed that overall improvement in outcome was statistically significant. [ 1 ]…”

“…Contrary to the above results, Kocherov et al ., in their study, failed to demonstrate BioGlue's benefit in decreasing incidence of fistula formation. [ 22 ] Furthermore, patients from BioGlue group had unsatisfactory cosmetic appearance and had severe fibrotic skin reaction. [ 22 ] This suggests that a foreign body reaction may be triggered in some patients.…”

“…[ 22 ] Furthermore, patients from BioGlue group had unsatisfactory cosmetic appearance and had severe fibrotic skin reaction. [ 22 ] This suggests that a foreign body reaction may be triggered in some patients. Schmeeckle et al .…”

Impact of Molecular Architecture and Adsorption Density on Adhesion of Mussel-Inspired Surface Primers with Catechol-Cation Synergy

“…10 Other adhesives containing catechol and cationic functionalities include catechol-chitosan 11−13 and catechol-poly(ethylenimine), 14,15 among others. 16,17 Molecules containing Dopa and other catechols adhere to apatite 18 and metal oxide 19 surfaces found in bone and implant materials, and have been shown to be biocompatible, 20 making them attractive alternatives to existing medical adhesives, many of which are ineffective 21,22 or cytotoxic. 23−25 Despite widespread scientific and applications-based research on materials containing catechol functionalities, 20 specific adhesion mechanisms of these materials have only recently begun to be explored.…”

Prospective comparative study of hypospadias surgical repair with and without the use of fibrin sealant

“…Kocherov et al demonstrated no benefit using bioglue surgical adhesive in hypospadias repair in pediatric patients. 8 But in our study wound dehaisece didn't happen in15 patient after fibrogloo application.…”