Use of eggshell-derived nano-hydroxyapatite as novel bone graft substitute–A randomized controlled clinical study

Kattimani, Vivekanand; Lingamaneni, Krishna Prasad; Samatha, Y; Mupparapu, Mel

doi:10.1177/0885328219863311

Cited by 26 publications

(34 citation statements)

References 56 publications

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“…Moreover, eggshell-derived nano-hydroxyapatite for bone transplantation has strong safety and can obtain good bone regeneration performance. In the third month after implantation in patients, bone graft showed increased bone density and complete healing (Kattimani et al, 2019). Therefore, the use of ECM-modified scaffold in bone regeneration is significantly better than standard treatment by reducing the frequency of secondary intervention, while reducing the infection rate in patients with an open bone defect.…”

Section: Ecm-modified Biomaterials Scaffoldmentioning

confidence: 99%

The Bone Extracellular Matrix in Bone Formation and Regeneration

et al. 2020

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Bone regeneration repairs bone tissue lost due to trauma, fractures, and tumors, or absent due to congenital disorders. The extracellular matrix (ECM) is an intricate dynamic bio-environment with precisely regulated mechanical and biochemical properties. In bone, ECMs are involved in regulating cell adhesion, proliferation, and responses to growth factors, differentiation, and ultimately, the functional characteristics of the mature bone. Bone ECM can induce the production of new bone by osteoblast-lineage cells, such as MSCs, osteoblasts, and osteocytes and the absorption of bone by osteoclasts. With the rapid development of bone regenerative medicine, the osteoinductive, osteoconductive, and osteogenic potential of ECM-based scaffolds has attracted increasing attention. ECM-based scaffolds for bone tissue engineering can be divided into two types, that is, ECM-modified biomaterial scaffold and decellularized ECM scaffold. Tissue engineering strategies that utilize the functional ECM are superior at guiding the formation of specific tissues at the implantation site. In this review, we provide an overview of the function of various types of bone ECMs in bone tissue and their regulation roles in the behaviors of osteoblast-lineage cells and osteoclasts. We also summarize the application of bone ECM in bone repair and regeneration. A better understanding of the role of bone ECM in guiding cellular behavior and tissue function is essential for its future applications in bone repair and regenerative medicine.

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Section: Ecm-modified Biomaterials Scaffoldmentioning

confidence: 99%

The Bone Extracellular Matrix in Bone Formation and Regeneration

et al. 2020

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“…All included articles were non-RCTs (n = 4) [27][28][29][30], except for one RCT [31]. One study employed a split-mouth design [31], one study used two parallel groups (n = 10) [28], with the remaining three studies being pilot studies [27,29,30]. The number of patients per study ranged from 8 to 21, with a total of 74 included in this analysis.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The RCT compared the efficacy of the eggshell to that of the control site [31], one non-RCT compared the efficacy of the eggshell to that of HA after cystectomy [28], one used the eggshell in socket preservation [30], and the remaining two non-RCTs used the eggshell in regeneration after cystectomy/ apicectomy [27,29].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…All studies presented follow-up of gingival and bone healing at 3 months [27], 4 months [29,30], or 6 months [28,31]. In all the included studies, patients were followed-up through clinical evaluation and imaging.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…In all the included studies, patients were followed-up through clinical evaluation and imaging. For one study covering 24 weeks [31], a biopsy was taken using trephine bur, then micro computed tomography and histological assessment were provided subsequently. Only one complication (wound dehiscence) was reported [29], and two other patients were excluded from the study due to the lack of follow-up [31].…”

Section: Study Characteristicsmentioning

confidence: 99%

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Clinical applications of avian eggshell-derived hydroxyapatite

Opriș

Bran

Dinu

et al. 2020

Bosn J of Basic Med Sci

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The search for bone reconstruction materials and methods is an ongoing challenge. The aim of this review is to systemically search the available literature concerning the clinical performance of eggshell as a substitute material in guided bone regeneration in oral surgery. Five databases (PubMed, Cochrane, Web of Science, Scopus, and Embase) were searched up to February 2020. Clinical trials that used eggshell as a bone substitute material were included. Animal and in vivo studies were excluded. ROBINS-I was used to evaluate the risk of bias. A total of 840 studies were retrieved, out of which 55 full-text articles were screened. Five studies were finally included: one study showed critical and four serious risk of bias. A total of 74 patients and 88 intervention sites were included in the five studies. Clinical and radiological evaluation showed complete healing during the follow-ups. Statistically significant radiological and clinical evidence of new bone formation was achieved for socket preservation, grafting after third molar extraction, and cystic/apicectomy grafting. One patient with complications was reported. Histological analysis and micro computed tomography confirmed that it promotes bone regeneration. A comparison with synthetic hydroxyapatite showed similar healing characteristics. Within the limitations of the included studies, eggshell can be safely and efficiently used in guided bone regeneration procedures, but more research is needed to completely evaluate the full potential of this material.

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A novel classification of bone graft materials

2022

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Over the past few decades, the field of biomaterials concerning bone tissue engineering has gained a significant amount of interest. This has led to new biomaterials to be used as bone substitute materials. Despite the rapid increase in the types and forms of bone substitutes, a comprehensive classification encompassing all types of bone graft materials that have so far been developed and evaluated is lacking. Therefore, this review aims to integrate and bring together the published data on bone substitutes within the last 5 years and produce a novel classification that would provide bone material researchers with a better understanding of what materials have so far been used and evaluated and the areas, where research is lacking and deserves more attention. The literature available in all major databases was obtained and filtered using an elimination criterion to extract all the articles related to studies that tested bone substitute materials in nonclinical and clinical trials over the last 5 years. The review article would provide bone material researchers with an insight into the materials that have been evaluated for bone tissue engineering applications and identify future perspectives for bone graft material research.

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Use of eggshell-derived nano-hydroxyapatite as novel bone graft substitute–A randomized controlled clinical study

Cited by 26 publications

References 56 publications

The Bone Extracellular Matrix in Bone Formation and Regeneration

The Bone Extracellular Matrix in Bone Formation and Regeneration

Clinical applications of avian eggshell-derived hydroxyapatite

A novel classification of bone graft materials

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