Use of dextran nanoparticle: A paradigm shift in bacterial exopolysaccharide based biomedical applications

Banerjee, Aparna; Bandopadhyay, Rajib

doi:10.1016/j.ijbiomac.2016.02.059

Cited by 100 publications

(46 citation statements)

References 35 publications

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“…Its simple and unique biopolymer properties make it ideal for nanomedicine, nanomedicine carriers, and cell imaging systems or nanobiosensors. Most importantly, it is very soluble in water and does not show cytotoxicity after drug delivery [76]. Prepare various dextran coated nanoparticles and optimize for drug delivery and targeting [50].…”

Section: Dextranmentioning

confidence: 99%

Applications of polymer-based nanoparticles in vaccine field

Guo

Utupova

et al. 2019

Nanotechnology Reviews

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Polymer-based nanoparticles have good solubility, stability, safety, and sustained release,which increases the absorption of loaded drugs, protects the drugs from degradation, and prolongs their circulation time and targeted delivery. Generally, we believe that prevention and control of infectious diseases through inoculation is the most efficient measure. However, these vaccines including live attenuated vaccines, inactivated vaccines, protein subunit vaccines, recombinant subunit vaccines, synthetic peptide vaccines and DNA vaccines have several defects, such as immune tolerance, poor immunogenicity, low expression level and induction of respiration pathological changes. All kinds of biodegradable natural and synthetic polymers play major roles in the vaccine delivery system to control the release of antigens for an extended period of time. In addition, these polymers also serve as adjuvants to enhance the immunogenicity of vaccine. This review mainly introduces natural and synthetic polymer-based nanoparticles and their formulation and properties. Moreover, polymer-based nanoparticles as adjuvants and delivery carriers in the applications of vaccine are also discussed. This review provides the basis for further operation of nano vaccines by utilizing the polymer-based nanoparticles as vaccine adjuvants and delivery systems. Polymer-based nanoparticles have exhibited great potential in improving the immunogenicity of antigens and the development of nano vaccines in future.

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Section: Dextranmentioning

confidence: 99%

Applications of polymer-based nanoparticles in vaccine field

Guo

Utupova

et al. 2019

Nanotechnology Reviews

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“…Since then, this catalyst-free aqueous glycol (1,2-diol) cleavage has been known as Malaprade oxidation [120], whose mechanism is assumed to involve an acidic cyclic ester intermediate that decomposes to yield two carbonylic compounds, as shown in Figure 3. Thus, by using any of the previously mentioned methods, dextrans have been applied as macromolecular carriers for the delivery of drugs and proteins, aiming to increase the durability of several therapeutic agents inside the systemic circulation [86,[91][92][93][94][95]. In fact, molecules with Mw < 40 kDa (half-life times of around 8 h) are easily eliminated via renal filtering, whereas upon dextranconjugation, the molecular weight of these prodrugs may be increased to values higher than 40 kDa, leading to increased half-lives.…”

Section: Dextran Aldehyde (Dexox)mentioning

confidence: 99%

Dextran Aldehyde in Biocatalysis: More Than a Mere Immobilization System

et al. 2019

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Dextran aldehyde (dexOx), resulting from the periodate oxidative cleavage of 1,2-diol moiety inside dextran, is a polymer that is very useful in many areas, including as a macromolecular carrier for drug delivery and other biomedical applications. In particular, it has been widely used for chemical engineering of enzymes, with the aim of designing better biocatalysts that possess improved catalytic properties, making them more stable and/or active for different catalytic reactions. This polymer possesses a very flexible hydrophilic structure, which becomes inert after chemical reduction; therefore, dexOx comes to be highly versatile in a biocatalyst design. This paper presents an overview of the multiple applications of dexOx in applied biocatalysis, e.g., to modulate the adsorption of biomolecules on carrier surfaces in affinity chromatography and biosensors design, to serve as a spacer arm between a ligand and the support in biomacromolecule immobilization procedures or to generate artificial microenvironments around the enzyme molecules or to stabilize multimeric enzymes by intersubunit crosslinking, among many other applications.

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“…Dextran nanoparticles have superior aqueous solubility, high cargo capacity and intrinsic viscosity, and short storage period. 46 The features of the most promising proteins, namely collagen, gelatin, elastin, silk fibroin, sericin and soy protein used for TERM are described in the following paragraphs.…”

Section: Plant Polysaccharidesmentioning

confidence: 99%

2.11 Polymers of Biological Origin ☆

Silva

Fernandes

Pina

et al. 2017

Comprehensive Biomaterials II

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Recent advances in tissue engineering and regenerative medicine have shown that combining biomaterials, cells, and bioactive molecules are important to promote the regeneration of damaged tissues or as therapeutic systems. Natural origin polymers have been used as matrices in such applications due to their biocompatibility and biodegradability. This chapter provides an up-to-date review on the most promising natural biopolymers, focused on polysaccharides and proteins, their properties and applications. Membranes, micro/ nanoparticles, scaffolds, and hydrogels as biomimetic strategies for tissue engineering and processing are described, along with the use of bioactive molecules and growth factors to improve tissue regeneration potential. Finally, current biomedical applications are also presented.

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Use of dextran nanoparticle: A paradigm shift in bacterial exopolysaccharide based biomedical applications

Cited by 100 publications

References 35 publications

Applications of polymer-based nanoparticles in vaccine field

Applications of polymer-based nanoparticles in vaccine field

Dextran Aldehyde in Biocatalysis: More Than a Mere Immobilization System

2.11 Polymers of Biological Origin ☆

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