Use of Cervical Ultrasonography in Globus Sensation Investigation: A Retrospective Cohort Study

Fukuhara, Takahiro; Matsuda, Eriko; Ogawa, Ayame; Donishi, Ryohei; Koyama, Satoshi; Fujiwara, Kazunori

doi:10.33160/yam.2021.11.007

Cited by 2 publications

(2 citation statements)

References 8 publications

(10 reference statements)

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“…37 In addition, another study using ultrasound in ENT patients only also found a low incidence of cancer in patients with GP. 38 These results align with the ones from our study, because those who underwent workup without worsening symptoms did not develop HN cancer.…”

Section: Discussionsupporting

confidence: 90%

“…A previous study which evaluated the population of an ENT center assessing the benefits of ultrasound versus videofluroscopy found that those with chronic symptoms did not develop HN cancer 37 . In addition, another study using ultrasound in ENT patients only also found a low incidence of cancer in patients with GP 38 . These results align with the ones from our study, because those who underwent workup without worsening symptoms did not develop HN cancer.…”

Section: Discussionsupporting

confidence: 90%

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The Development of Head and Neck Cancer in Patients with the Isolated Complaint of Globus Pharyngeus

Maronian,

Cabrera,

Dewey

et al. 2023

The Laryngoscope

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ObjectivesGlobus pharyngeus (GP) is a perplexing problem that accounts for 4% of referrals to otolaryngologists. Workup can be extensive and may not be definitive in terms of etiology. The concern that lingers is that of a subtle cancer, which can prolong anxiety and increase testing cost. The aim of this study was to identify the incidence of head and neck cancer (HNC) in patients diagnosed with GP.MethodsLongitudinal data were captured from two academic institutions, identifying patients with a new diagnosis of globus pharyngeus in 2015. The patient cohort was tracked for at least 4 years to assure follow‐up and ability to determine if a HNC developed. Additional demographic data was also collected to determine most common consults, treatments, and testing employed.ResultsExcluding patients with previous diagnosis of HNC, 377 patients were identified who presented with GP in 2015 that had at least 4 years of follow‐up. Demographics were predominantly women (64.65%), with a mean age of 56.48 years at diagnosis, and the most common provider specialty on the first visit was otolaryngology (39.52%). Four patients ultimately developed HN cancer, for an overall incidence of 1% for the 4‐year period of 2015–2019.ConclusionsGiven the long‐term follow‐up of this population, the overall incidence of developing a head and neck cancer, with a presenting symptom of globus, is low. This is the largest study to date to report the percentage of patients endorsing GP to then subsequently develop HNC. This helps otolaryngologists to reassure patients who have a normal comprehensive exam, flexible endoscopy, and targeted studies.Level of EvidenceIV Laryngoscope, 2023

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

The Development of Head and Neck Cancer in Patients with the Isolated Complaint of Globus Pharyngeus

Maronian,

Cabrera,

Dewey

et al. 2023

The Laryngoscope

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Local symptoms of Hashimoto’s thyroiditis: A systematic review

Yuan

Qi²,

Zhang³

et al. 2023

Front. Endocrinol.

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ObjectiveHashimoto’s thyroiditis (HT) is the most common type of thyroid disease and can cause many different manifestations. The local symptoms of HT are an under-studied area of research. Therefore, the purpose of this study was to investigate the local symptoms of HT and their prevalence.MethodsA systematic review was performed to find articles in PubMed that discuss the local symptoms of HT. Relevant vocabulary terms and key terms included: autoimmune thyroid disease (AITD), hyperthyroidism, hypothyroidism, neck, throat, pharynx, airway, esophagus, breathe, swallow, globus, sleep apnea, symptoms, and quality of life. Two investigators independently screened the eligible studies.ResultsA total of 54 articles fulfilled the inclusion criteria. Of these, 25 were clinical studies, 24 were case reports, and five were reviews. These clinical studies and case reports included a total of 2660 HT patients. There were eight local symptoms related to HT: neck pain (0.02%~16%), voice changes (7%~30%), throat discomfort (20%~43.7%), shortness of breath (28%~50%), dysphagia (29%), goiter-related symptoms (69.44%), sleep apnea, and generally defined compressive symptoms. Due to the use of different outcome measures among all the studies, a meta-analysis of the data could not be performed.ConclusionGoiter symptoms, which are an item on the ThyPRO scales, are the most frequent local symptoms in HT patients, and include neck pain, voice changes, throat discomfort, and dysphagia. These local symptoms should be identified in the clinic and included in the early diagnosis and management of HT, as well as evaluated further to understand their relevance in the pathogenesis of HT.

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Use of Cervical Ultrasonography in Globus Sensation Investigation: A Retrospective Cohort Study

Cited by 2 publications

References 8 publications

The Development of Head and Neck Cancer in Patients with the Isolated Complaint of Globus Pharyngeus

The Development of Head and Neck Cancer in Patients with the Isolated Complaint of Globus Pharyngeus

Local symptoms of Hashimoto’s thyroiditis: A systematic review

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