Use of aspirin to intentionally induce gastrointestinal tract barrier dysfunction in feedlot cattle

Briggs, Nathan G; Brennan, K. M.; Funnell, Bethany J.; Nicholls, Griffin; Schoonmaker, J. P.

doi:10.1093/jas/skaa264

Cited by 8 publications

(3 citation statements)

References 108 publications

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“…38 Aspirin, siklooksijenaz [cyclooxygenase (COX)-1)] ve COX-2 izoenzimlerinin aktif bölgesine kovalent olarak bağlanır. 39 COX, araşidonik asitten prostaglandin üretimi için kullanılır. Prostaglandinler, ağrı ve iltihaplanma ile ilişkili olmasının yanı sıra koruyucu mukus üretimini indükler ve mukozal onarım sağlar.…”

Section: Geçi̇rgen Bağirsak Sendromunun Oluşumuna Etki̇ Eden Etmenlerunclassified

“…40 İnsanlarda aspirinin sık veya yoğun kullanımının GI sistem bariyer işlev bozukluğuna ve ülserasyona neden olduğu bilinmektedir. 38,39,41 GI sistem disfonksiyonu ve ülserasyon, inflamasyon tarafından işaret edilen bir bağışıklık tepkisine neden olur. Bu nedenle NSAID'lerin kullanımı sonunda ince bağırsak iltihabına ve buna bağlı kan ve protein kaybına neden olabilir.…”

Section: Geçi̇rgen Bağirsak Sendromunun Oluşumuna Etki̇ Eden Etmenlerunclassified

“…İdrarla atılan Cr miktarı, Cr'nin absorpsiyon ve eliminasyon kinetiğine dayalı olarak büyük miktarda GI sistem bariyeri disfonksiyonuna neden olduğunu bildirmişlerdir. 39…”

Section: Geçi̇rgen Bağirsak Sendromunun Oluşumuna Etki̇ Eden Etmenlerunclassified

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Leaky Gut Syndrome in Dairy Cattle: Traditional Review

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KARAKAŞ OĞUZ

2023

Turkiye Klinikleri J Vet Sci

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Section: Geçi̇rgen Bağirsak Sendromunun Oluşumuna Etki̇ Eden Etmenlerunclassified

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Leaky Gut Syndrome in Dairy Cattle: Traditional Review

OĞUZ,

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2023

Turkiye Klinikleri J Vet Sci

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Effect of aspirin to intentionally induce leaky gut on performance, inflammation, and carcass characteristics of feedlot cattle

Briggs

Silva

Godoi

et al. 2021

Journal of Animal Science

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The negative impacts of stress on gastrointestinal tract (GIT) barrier function can result in compromised animal growth and health. Aspirin is known to cause mucosal injury leading to increased gut permeability and tight junction damage and can be used as a model to study leaky gut in cattle. The objective of this study was to determine the long-term impact of aspirin-induced chronic leaky gut on cattle growth and carcass attributes. Two treatments were evaluated in two studies: control (no aspirin) or 0.25% of the diet dry matter (DM) aspirin fed daily. Diets consisted of 50% corn, 24% dried distillers grains, 20% corn silage, and 6% supplement on a DM basis. In experiment 1, sixteen Angus × Simmental heifers, allotted by body weight (BW) and breed composition, were fed diets for 154 d. On day 155, heifers were dosed with 1 liter of a 180-mM Cr–ethylenediaminetetraacetic acid solution using an esophageal tube and had urine collected every 1.5 to 3 h for 48 h for analysis of Cr as a measure of gut leakiness. In experiment 2, ninety-six Simmental × Angus steers (355.0 ± 14.8 kg) were allotted by BW and breed composition and fed treatment diets for 159 d. Weight was recorded monthly and serum was collected on day 159 and analyzed for lipopolysaccharide-binding protein (LBP), interleukin-6 (IL-6), serum amyloid A (SAA), haptoglobin, and aspartate aminotransferase (AST). Data were analyzed using the MIXED procedure of SAS. Heifers fed 0.25% aspirin in experiment 1 excreted more Cr into urine compared with heifers not fed aspirin (overall treatment effect, P = 0.01). In experiment 2, aspirin tended to increase serum LBP (P = 0.06) but had no effect on concentrations of IL-6, haptoglobin, SAA, or AST (P ≥ 0.25). Aspirin tended to decrease average daily gain (P = 0.10), decreased hot carcass weight and rib-eye area (P ≤ 0.05), and increased fat thickness, marbling score, and yield grade (P ≤ 0.02). Aspirin tended to increase kidney, pelvic, and heart fat percentage (P = 0.10) and had no effect on liver abscesses (P ≥ 0.80). This study indicates that leaky gut induced by long-term administration of aspirin has negative impacts on feedlot performance and carcass composition. The negative impact of aspirin-induced leaky gut on animal performance suggests that chronic leaky gut caused by other factors (subacute acidosis, stress) may be a significant problem for the feedlot industry.

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Effect of feeding calcium gluconate embedded in a hydrogenated fat matrix on feed intake, gastrointestinal fermentation and morphology, intestinal brush border enzyme activity and blood metabolites in growing lambs

Watanabe

Doelman²,

Steele

et al. 2022

Journal of Animal Science

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Gluconate salts have been identified as a butyrate precursor when fed to non-ruminant species and may increase the butyrate concentration in the large intestine supporting gastrointestinal health and development. The objective of this study was to evaluate the dose response of hydrogenated fat-embedded calcium gluconate (HFCG) on performance and gastrointestinal tract (GIT) development in growing lambs. Thirty-two wether lambs were used in a randomized complete block design and assigned to 1 of 4 treatments differing in the inclusion of HFCG: 0.0% (CON), 0.075% (LOW), 0.30% (MED), and 0.60% of the diet (HIGH). Lambs were allocated into individual pens and fed ad libitum with feed delivered twice daily. Feed intake was recorded daily, and body weight (BW) was assessed at the beginning and the end of the 29-d period. Blood was sampled on d 21, prior to feeding and 6 h post-feeding to evaluate changes in β-hydroxybutyrate, glucose, and insulin concentrations. Total fecal collection was conducted during d 25 to 28 to assess apparent total tract digestibility. On d 29, lambs were slaughtered, and the entire GIT was separated by region to enable sampling of tissue and digesta. Data were analyzed to assess linear, quadratic, and cubic effects of HFCG dose. Final BW, average daily gain, and dry matter intake decreased linearly (P ≤ 0.02) with increasing HFCG. Increasing inclusion of HFCG linearly decreased (P = 0.01) the thickness of the stratum corneum in ruminal papillae but did not affect other strata (P ≥ 0.34). Omasal digesta weight linearly decreased (P = 0.01) as the concentration of HFCG increased and abomasal digesta weight was cubically affected (P = 0.03) the increasing dose of HFCG. Short-chain fatty acid concentration in the cecum was cubically affected (P < 0.01) with increasing dose of HFCG where low dose had the greatest concentration. Moreover, increasing the dietary supply of HFCG linearly increased the proportion of acetate (P = 0.04) in the cecum and linearly decreased the proportion of propionate in the digesta of both the cecum (P < 0.01) and colon (P = 0.01). Colon crypt depth was quadratically (P = 0.03) affected with the increasing dose of HFCG, where lambs fed MED had greatest crypt depth. We conclude that feeding HFCG to growing lambs did not increase butyrate concentration in the large intestine and consequently does not increase the absorptive surface area of the whole tract, the size of the GIT, or the functionality of the intestine.

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Use of aspirin to intentionally induce gastrointestinal tract barrier dysfunction in feedlot cattle

Cited by 8 publications

References 108 publications

Leaky Gut Syndrome in Dairy Cattle: Traditional Review

Leaky Gut Syndrome in Dairy Cattle: Traditional Review

Effect of aspirin to intentionally induce leaky gut on performance, inflammation, and carcass characteristics of feedlot cattle

Effect of feeding calcium gluconate embedded in a hydrogenated fat matrix on feed intake, gastrointestinal fermentation and morphology, intestinal brush border enzyme activity and blood metabolites in growing lambs

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