Use of Animal Models in the Study of Colitis

Rezende, Karoline S.; Fernandes, Melina Ribeiro; Faria, Bernardo B. de; Guimarães, RitaC. A.; Freitas, Karine C.

doi:10.5772/intechopen.75608

Cited by 3 publications

(2 citation statements)

References 81 publications

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“…The severity and degree of inflammation in TNBS-induced colitis depends on the genetic factors inherent in the animal and the presence or absence of bacteria that activate T cells. CD4 + T cells are strongly associated with Th1-mediated immune responses via the cytokine IL-12, which make the symptoms similar to chron disease [10] 4 Dinitrobenzene Sulfonic Acid .…”

Section: Trinitrobenzene Sulfonic Acidmentioning

confidence: 99%

Chemically-Induced Colitis Models in Animal

2021

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Ulcerative colitis is a chronic inflammation that can affect the distal part of the colon, submucosa and rectal mucosa, and can affect the entire colon even to the terminal ileum. There are several factors that can cause this disease, such as genetics, environment, intestinal microbiota and the presence of enteric infectious agents. Chemical induction in experimental animals for research on gastrointestinal inflammation has been frequently used due to the similarity of the anatomical and physiological structures of experimental animals with the human digestive tract. This review focuses on recent understanding of the chemicals that used as induction agents in animals

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Section: Trinitrobenzene Sulfonic Acidmentioning

confidence: 99%

Chemically-Induced Colitis Models in Animal

2021

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“…Because of their simplicity, chemical colitogens can be used in several experimental protocols. They induce intestinal inflammation by the disruption of the mucosal barrier and/or by triggering hapten-associated hypersensitivity reactions, yet they do not recapitulate the complete IBD pathology [ 56 ]. Perhaps the most widely used DSS-induced experimental colitis is characterized by the death of epithelial cells, intestinal barrier dysfunction, and subsequent inflammation due to the dissemination of pro-inflammatory intestinal contents (e.g., bacteria and their products) into underlying tissue.…”

Section: Resultsmentioning

confidence: 99%

Gastrointestinal Dopamine in Inflammatory Bowel Diseases: A Systematic Review

Kurnik‐Łucka

Pasieka

et al. 2021

IJMS

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Background: an increased prevalence of gastro-duodenal ulceration was described almost sixty years ago as prodromal to idiopathic Parkinson’s disease, while duodenal ulcers have been rarely diagnosed in patients with schizophrenia. The cytoprotective role of dopamine in animal models of gastrointestinal ulcerations has also been described. Interestingly, Parkinson’s disease (PD) might share common pathophysiological links with inflammatory bowel disease (IBD) as epidemiological and genetic links already suggest. Thus, the aim of our study was to review the existing literature on the role of the gastrointestinal dopaminergic system in IBD pathogenesis and progression. Methods: a systematic search was conducted according to the PRISMA methodology. Results: twenty-four studies satisfied the predetermined criteria and were included in our qualitative analysis. Due to different observations (cross-sectional studies) as well as experimental setups and applied methodologies (in vivo and in vitro studies) a meta-analysis could not be performed. No ongoing clinical trials with dopaminergic compounds in IBD patients were found. Conclusions: the impairment of the dopaminergic system seems to be a significant, yet underestimated, feature of IBD, and more in-depth observational studies are needed to further support the existing preclinical data.

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Protective effects of yacon syrup powder on colonic interleukin-23 and leukocyte infiltration profile in TNBS-induced colitis mouse model

Rahmaisyah

Wasityastuti

Astarini

et al. 2022

MNM

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BACKGROUND: Inflammatory Bowel Disease (IBD) causes gastrointestinal tract dysregulation and triggers inflammation. Severe inflammatory events often lead to leukocyte infiltration. Yacon is known to have anti-inflammatory properties, making it a potential alternative treatment for colitis. AIMS: To investigate colonic Interleukin-23 (IL-23) level and leukocyte infiltration profile in 2,4,6-Trinitrobenzene Sulfonic Acid (TNBS)-induced colitis mouse model treated with yacon syrup powder. METHODS: Thirty male BALB/c mice (5 weeks old, body weight: 30.02±1.28 g) were randomly divided into 6 groups (K1-K6). Intra-rectal administration of TNBS was performed to K2-K6 to make the colitis model. K4-K6 were given yacon syrup powder daily for 14 days with the dose of 0.165, 0.331, and 0.662 g/30 g body weight (BW) respectively. IL-23 levels of colonic tissue were measured using ELISA. Leukocyte infiltration profile was calculated through microscopic observation of histology slides and presented in percentage and degree. RESULTS: Significantly different IL-23 levels were observed among the groups (P < 0.001). The percentage and degree of leukocyte infiltration in yacon-treated groups showed a significant decrease compared to colitis groups (P < 0.001). CONCLUSION: Yacon syrup powder provides beneficial effects on colitis mice by lowering the IL-23 level and number of leukocytes at the inflammation site.

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Use of Animal Models in the Study of Colitis

Cited by 3 publications

References 81 publications

Chemically-Induced Colitis Models in Animal

Chemically-Induced Colitis Models in Animal

Gastrointestinal Dopamine in Inflammatory Bowel Diseases: A Systematic Review

Protective effects of yacon syrup powder on colonic interleukin-23 and leukocyte infiltration profile in TNBS-induced colitis mouse model

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