1996
DOI: 10.1590/s0104-79301996000100003 View full text |Buy / Rent full text
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Abstract: A sandwich-type ELISA technique for specific and sensitive detection of Crotalus durissus terrificus venom antigens, horse-antivenom, human IgG and IgM antibodies was set up. Sixteen patients, 13 males and 3 females aged between 13 to 63 years (mean 33 ± 15) bitten by Crotalus durissus terrificus snakes were studied. Of the 15 patients, 6 had previously received anti-Crotalus venom and no seric venom was detected. For the other 9 patients studied, the venom levels ranged from 2 to 108 ng/ml according to the se… Show more

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“…Compared with the 4 ml single dosing, the additional 2 ml of antivenom 1 hr later was sufficient to neutralize the resurged venom antigens and to reduce further the subsequent antigenemia to significantly lower levels, resulting in a significant decrease in the total antigenemia (67.1%, indicated by AUC 1–24 h ) compared with the untreated group. The result suggests that NPAV at the given regimen is able to reduce or reverse the toxic effects of N. sputatrix venom as serum venom antigen level is known to correlate with the severity of envenomation . Overall, our results support the use of a high initial dose of NPAV, as recommended by the manufacturer (10 vials, equivalent to 100 ml) to rapidly induce a sharp decline in venom antigen levels.…”
Section: Discussionsupporting
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“…Compared with the 4 ml single dosing, the additional 2 ml of antivenom 1 hr later was sufficient to neutralize the resurged venom antigens and to reduce further the subsequent antigenemia to significantly lower levels, resulting in a significant decrease in the total antigenemia (67.1%, indicated by AUC 1–24 h ) compared with the untreated group. The result suggests that NPAV at the given regimen is able to reduce or reverse the toxic effects of N. sputatrix venom as serum venom antigen level is known to correlate with the severity of envenomation . Overall, our results support the use of a high initial dose of NPAV, as recommended by the manufacturer (10 vials, equivalent to 100 ml) to rapidly induce a sharp decline in venom antigen levels.…”
Section: Discussionsupporting
“…Although there was no significant difference between IgG results at days 14 and 28 after treatment, there was a tendency to higher values in patients evaluated at day 28. The fact that equine antibody half-life is approximately 21 days in serum and that they can be detected up to 44 days after treatment corroborates this hypothesis (7,8,13,55,58).…”
Section: Resultssupporting
“…This method has showed to present the best specificity, sensitivity, fastness, simplicity, and low costs (3,4,6,32,35,39,44). Results showed that the optical density values obtained in the ELISA test for the several dilutions of the native and irradiated venoms of Bothrops jararaca, Bothrops jararacussu and Bothrops moojeni did not show statistical difference between the groups studied.…”
Section: Discussionmentioning