Background and aimCoronary heart disease (CHD) is a chronic complex disease caused by a combination of factors such as lifestyle behaviors and environmental and genetic factors. We conducted this study to evaluate the risk factors affecting the development of CHD in Xinjiang, and to obtain valuable information for formulating appropriate local public health policies.
MethodWe conducted a nested case-control study with 277 confirmed CHD cases and 554 matched controls. The association of the risk factors with the risk of CHD was assessed using the multivariate Cox proportional hazard model. Multiplicative interactions were evaluated by entering interaction terms in the Cox proportional hazard model. The additive interactions among the risk factors were assessed by the index of additive interaction.
ResultsThe risk of CHD increased with frequent high-fat food consumption, dyslipidemia, obesity, and family history of CHD after adjustment for drinking, smoking status, hypertension, diabetes, family history of hypertension, and family history of diabetes. We noted consistent interactions between family history of CHD and frequent high-fat food consumption, family history of CHD and obesity, frequent high-fat food consumption and obesity, frequent high-fat food consumption and dyslipidemia, and obesity and dyslipidemia. The risk of CHD events increased with the presence of the aforementioned interactions.
ConclusionsFrequent high-fat food consumption, family history of CHD, dyslipidemia and obesity were independent risk factors for CHD, and their interactions are important for public health interventions in patients with CHD in Xinjiang.
PLOS ONEPLOS ONE | https://doi.org/10.Cases were selected from among the participants who experienced their first CHD event during the follow-up. The presence of CHD was determined on the basis of self-reported questionnaire responses, medical insurance records, and local hospital discharge records from 2009 to 2017. Patients with self-reported CHD findings were required to have a certificate of CHD diagnosis from the medical institution of their township during investigation. Multiple
PLOS ONENested case-control study of coronary heart disease PLOS ONE | https://doi.org/10.