Use and outcomes of intracytoplasmic sperm injection for non–male factor infertility

Kim, Howard H.; Bundorf, M. Kate; Behr, Barry; McCallum, Stewart W.

doi:10.1016/j.fertnstert.2006.12.013

Cited by 49 publications

(43 citation statements)

References 24 publications

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“…We did not observe the decreased incidence of TFF; even higher incidence of TFF was observed although statistically insignificant. In contrast to our results, Kim et al reported that ICSI in patients with non-male factor infertility did not improve fertilization rate [11]. These differences might have risen from the study subjects evaluated; in the study by Kim et al, the subjects were couples with non-male factors [11], whereas in our study, the subjects had a particular concern about fertilization failure.…”

Section: Commentscontrasting

confidence: 99%

Can intracytoplasmic sperm injection prevent total fertilization failure and enhance embryo quality in patients with non-male factor infertility?

Kim¹,

Kim²,

Jee³

et al. 2014

European Journal of Obstetrics & Gynecology and Reproductiv

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Section: Commentscontrasting

confidence: 99%

Can intracytoplasmic sperm injection prevent total fertilization failure and enhance embryo quality in patients with non-male factor infertility?

Kim¹,

Kim²,

Jee³

et al. 2014

European Journal of Obstetrics & Gynecology and Reproductiv

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“…While there have been prospective trials to compare IVF outcomes in CI versus ICSI, women with poor ovarian response [24] or previous low responders [25] have had cycles cancelled or have been excluded. In couples without poor response to COH, ICSI has no proven benefit over CI and is a more invasive and expensive technique [24][25][26][27][28]. Prospective randomized trials studying low response to COH have not been performed.…”

Section: Discussionmentioning

confidence: 99%

Should ICSI be recommended routinely in patients with four or fewer oocytes retrieved?

Luna

Bigelow

Duke

et al. 2011

J Assist Reprod Genet

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Purpose To determine if patients with a low response to controlled ovarian hyperstimulation during IVF benefit from intracytoplasmic sperm injection (ICSI) Methods Retrospective analysis of 350 IVF cycles in which four or fewer oocytes were retrieved. Severe male factor cases were excluded from analysis. Conventional insemination (CI) and ICSI were compared, with primary outcome measures of fertilization rate, implantation rate, clinical pregnancy rate per embryo transfer, and pregnancy loss rate. Result(s) Fertilization rates per oocyte retrieved for CI and ICSI were comparable (51.5% vs. 51.8%). Parallel implantation rates (22% vs. 25%), clinical pregnancy rates (32.8% vs. 33.3%), and loss rates (26.7% vs. 39.5%) were also noted. No difference in cancelled cycles was reported. Conclusion(s) Our results demonstrate that in the presence of normal semen parameters, low egg number is not an indication to perform ICSI.

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“…Recently, however ICSI has been increasingly used in cases where conventional in vitro fertilization (IVF) would not necessarily be inefficient (Oehninger and Gosden, 2002;van der Westerlaken et al, 2005;Kim et al, 2007). The advantage of ICSI with non-male factor infertility is still the subject of debate.…”

Section: Introductionmentioning

confidence: 99%

“…Staessen et al (1999), Fishel et al (2000), Plachot et al (2002), Elizur et al (2004), and van der Westerlaken et al (2006) have stated that one advantage of ICSI is avoiding the risk of fertilization failure. However, many authors have reported no differences in terms of fertilization and implantation rates between ICSI and IVF (Bukulmez et al, 2000;Kim et al, 2007). In addition, some researches have indicated that ICSI is more efficient in terms of the number of fertilized oocytes and good quality embryos (Khamsi et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Should few retrieved oocytes be as an indication for intracytoplasmic sperm injection?

Zhu

et al. 2012

J. Zhejiang Univ. Sci. B

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Abstract:Objective: To reevaluate whether relatively few oocytes obtained in one cycle are an indication for intracytoplasmic sperm injection (ICSI). Methods: A total of 406 cycles with three or fewer retrieved oocytes performed in 396 non-male infertile couples were retrospectively reviewed. Cycles were classified into three groups by different fertilization techniques: the in vitro fertilization (IVF) group, insemination with conventional IVF; the ICSI group, insemination with ICSI though semen parameters were normal; and the rescue ICSI group, re-insemination with ICSI after conventional IVF failure. Results: The ICSI group resulted in higher normal fertilization compared with the conventional IVF group. Correspondingly, the cycle cancellation rate was decreased in the ICSI group, though it was not statistically significant. The clinical pregnancy rate and implantation rate were lower in the ICSI group compared with the conventional IVF group. Rescue ICSI was a method to avert total fertilization failure in conventional IVF, increasing fertilization and ensuring embryo availability for transfer, but the normal fertilization was the lowest due to delayed insemination and the chance of pregnancy was very little. Conclusions: Obtaining only few oocytes in one cycle is not considered as an indication for ICSI when the sperm sample is apparently normal. Rescue ICSI is either not recommended if conventional insemination fails. Such patients should not be subjected to the unnecessary costs and potential risks of ICSI.

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Use and outcomes of intracytoplasmic sperm injection for non–male factor infertility

Cited by 49 publications

References 24 publications

Can intracytoplasmic sperm injection prevent total fertilization failure and enhance embryo quality in patients with non-male factor infertility?

Can intracytoplasmic sperm injection prevent total fertilization failure and enhance embryo quality in patients with non-male factor infertility?

Should ICSI be recommended routinely in patients with four or fewer oocytes retrieved?

Should few retrieved oocytes be as an indication for intracytoplasmic sperm injection?

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