Can intracytoplasmic sperm injection prevent total fertilization failure and enhance embryo quality in patients with non-male factor infertility?

Kim, Ju Yeong; Kim, Jee Hyun; Jee, Byung Chul; Lee, Jung Ryeol; Suh, Chang Suk; Kim, Seok Hyun

doi:10.1016/j.ejogrb.2014.03.044

Cited by 36 publications

(34 citation statements)

References 16 publications

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“…In in vivo ‐matured oocytes, ICSI resulted in a significantly higher normal FR and significantly lower multi‐PN formation rate than conventional insemination. This finding is also consistent with our recent report and this supports the benefit of ICSI in the non‐male‐factor IVF population.…”

Section: Discussionsupporting

confidence: 93%

“…Our indications for ICSI in non‐male‐factor infertility were as previously described: (i) ≤20% FR in a prior conventional insemination cycle; (ii) repetitive implantation failure ≥ 3 times; (iii) advanced maternal age (≥40 years); (iv) presence of endometrioma on the day of oocyte retrieval; (v) low oocyte yield (number of oocytes ≤ 3); or (vi) poor‐quality oocytes that included blood clots attached to the cumulus oophorus at the time of retrieval. The decision to perform ICSI was at the discretion of the attending physician and embryologist.…”

Section: Methodsmentioning

confidence: 99%

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Comparison of normal and abnormal fertilization of in vitro‐matured human oocyte according to insemination method

Park

Jee

Kim

2016

J of Obstet and Gynaecol

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Aim: Our purpose was to compare the normal fertilization rate, multi-pronuclei (PN) formation rate, and embryonic development of in vitro-matured oocytes between conventional insemination and intracytoplasmic sperm injection (ICSI). Methods: A total of 213 stimulated in vitro fertilization (IVF) cycles were selected, in which at least one immature oocyte was obtained (from 2010 to 2014). Immature oocytes were assigned to germinal vesicle (GV)-stage or metaphase I (MI)-stage oocyte groups. Cycles with obligatory ICSI due to male-factor infertility were excluded. Cycles were divided into two groups according to fertilization method: there were 97 cycles with conventional insemination and 116 cycles with ICSI. After in vitro maturation of 324 GV-stage oocytes and 341 MI-stage oocytes, the fertilization rate, multi-PN formation rate, and embryonic development were compared according to the fertilization method. Results: The normal fertilization rate was similar in the conventional insemination and the ICSI both in GV-derived and MI-derived oocytes. Both fertilization methods resulted in a similar multi-PN formation rate in GV-derived oocytes; however, in MI-derived oocytes, the multi-PN formation rate was zero with ICSI and this was significantly lower than that with conventional insemination (9.6%, P = 0.001). Conclusion: In non-male-factor infertility, ICSI should be considered when MI oocytes are matured.

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Section: Discussionsupporting

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Comparison of normal and abnormal fertilization of in vitro‐matured human oocyte according to insemination method

Park

Jee

Kim

2016

J of Obstet and Gynaecol

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“…Some researchers have gone as far as proposing ICSI for all in-vitro fertilization cases [3,25]. Nevertheless, there is a lack of evidence that ICSI improves fertilization and embryo implantation in the presence of normal sperm compared to conventional IVF [26][27][28], suggesting that the use of ICSI in all patients might not be justified [4,29].…”

Section: Introductionmentioning

confidence: 99%

Live birth rates using conventional in vitro fertilization compared to intracytoplasmic sperm injection in Bologna poor responders with a single oocyte retrieved

Sfontouris

Kolibianakis

Lainas

et al. 2015

J Assist Reprod Genet

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Conventional IVF and ICSI are associated with similar reproductive outcomes in poor responder patients with a single oocyte retrieved. Therefore, the choice of fertilization method should be based primarily on semen quality, in combination with the patient's previous history. A randomized controlled trial should be performed to confirm this study's findings that conventional IVF and ICSI have similar reproductive outcomes in poor responders.

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“…Another non-randomized study found no significant difference in FR, TFF, and clinical pregnancy rate in patients with non-male factor infertility [ 7 ], and a recent randomized study also support those findings [ 8 ]. In cases of poor oocyte quality, several studies support the efficacy of ICSI [ 9 , 10 ]. In addition, ICSI has been investigated as a possible fertilization method in patients with lower oocyte yield [ 10 , 11 , 12 ]; however, no study supported the routine use of ICSI in patients with low oocyte yield.…”

Section: Introductionmentioning

confidence: 99%

Embryonic development in human oocytes fertilized by split insemination

Kim

Youm

et al. 2015

Obstet Gynecol Sci

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ObjectiveTo compare the laboratory outcomes of intracytoplasmic sperm injection (ICSI) and conventional insemination using sibling oocytes in poor prognosis IVF cycles where ICSI is not indicated.MethodsCouples undergoing IVF with following conditions were enrolled: history of more than 3 years of unexplained infertility, history of ≥3 failed intrauterine insemination, leukocytospermia or wide variation in semen analysis, poor oocyte quality, or ≥50% of embryos had poor quality in previous IVF cycle(s). Couples with severe male factor requiring ICSI were excluded. Oocytes were randomly assigned to the conventional insemination (conventional group) or ICSI (ICSI group). Fertilization rate (FR), total fertilization failure, and embryonic development at day 3 and day 5 were assessed.ResultsA total of 309 mature oocytes from 37 IVF cycles (32 couples) were obtained: 161 were assigned to conventional group and 148 to ICSI group. FR was significantly higher in the ICSI group compared to the conventional group (90.5% vs. 72.7%, P<0.001). Total fertilization failure occurred in only one cycle in conventional group. On day 3, the percentage of cleavage stage embryos was higher in ICSI group however the difference was marginally significant (P=0.055). In 11 cycles in which day 5 culture was attempted, the percentage of blastocyst (per cleaved embryo) was significantly higher in the ICSI group than the conventional group (55.9% vs. 25.9%, P=0.029).ConclusionHigher FR and more blastocyst could be achieved by ICSI in specific circumstances. Fertilization method can be tailored accordingly to improve IVF outcomes.

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Can intracytoplasmic sperm injection prevent total fertilization failure and enhance embryo quality in patients with non-male factor infertility?

Cited by 36 publications

References 16 publications

Comparison of normal and abnormal fertilization of in vitro‐matured human oocyte according to insemination method

Comparison of normal and abnormal fertilization of in vitro‐matured human oocyte according to insemination method

Live birth rates using conventional in vitro fertilization compared to intracytoplasmic sperm injection in Bologna poor responders with a single oocyte retrieved

Embryonic development in human oocytes fertilized by split insemination

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