“…The argument is that voluntary disclosure is a special case of game theory, where an entity will disclose positive information while suppressing negative information, an outcome of the entity's optimising behaviour (Dye, 2001). Once disclosed, the real-options approach provides a theoretical rationale explaining why key non-financial performance variables are significant value 8 drivers of biotech-pharma companies, and that financial performance indicators are informative when released contemporaneously with non-financial performance indicators, such as drugs-in-progress (Eccles et al, 2001;Ely et al, 2003;Espinosa et al, 2009 It is argued in the literature that each stage represents definable progress for the R&D process, with patenting and pre-clinical trials categorised as basic exploration research, and with human clinical trials and NDA classified as exploitation (DiMasi, 1995;DiMasi, Hansen & Grabowski, 2003;Rothaernel & Deeds, 2004;McNamara and Baden-Fuller, 2007 One estimate is that five out of 5,000 new chemical entities proceed to human clinical trials, with only one likely to be granted approval, with an average total time of 12 years from discovery to market (Dedman et al, 2008). 5 It is generally accepted that mandatory regulated financial statements are less important in providing an insight into the likelihood of the marketing success of a developmental drug.…”