Ursolic acid: A natural preventive aesculapian for environmental hepatic ailments

Srivastava, Gunja; Singh, Mridweeka; Mishra, Anurag

doi:10.4103/ed.ed_12_17

Cited by 5 publications

(1 citation statement)

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“…Lipophilic fragments are of particular interest in the case of PPARs because PPARs are actively expressed in the liver and in adipose tissues [7]. Triterpenic acids and their derivatives have both hepatoprotective and anti-diabetic properties [8][9][10][11], while being at the same time of little toxicity [12]. These favorable characteristics may be explained by the presence of a steroid nucleus, thought to be important for strong hypoglycemic effects [13] and their significant lipophilicity.…”

Section: Introductionmentioning

confidence: 99%

Triterpenic Acid Amides as a Promising Agent for Treatment of Metabolic Syndrome

et al. 2020

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A series of triterpenic acid amides were synthesized incorporating a 2-ethoxy-3-phenylpropanoic acid pharmacophore fragment. The synthesized compounds were tested for their ability to improve glycemic control and to counter lipid abnormalities in C57BL/6 mice placed on a high-fat/high-cholesterol diet. Of all tested compounds, the dihydrobetulonic derivative (16b) had the most pronounced effect in decreasing blood glucose levels, total cholesterol (TC), and high-density lipoproteins (HDL). All the synthesized compounds displayed a relatively safe profile in the animal studies carried out in this work.

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Section: Introductionmentioning

confidence: 99%

Triterpenic Acid Amides as a Promising Agent for Treatment of Metabolic Syndrome

et al. 2020

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A comprehensive review on phytochemistry, molecular pharmacology, clinical and translational outfit of Ocimum sanctum L.

Pradhan

Biswasroy

Halder

et al. 2022

South African Journal of Botany

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Hepatoprotective Plants from Bangladesh: A Biophytochemical Review and Future Prospect

Rouf

Ghosh

Uzzaman

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Liver diseases are quite prevalant in many densely populated countries, including Bangladesh. The liver and its hepatocytes are targeted by virus and microbes, as well as by chemical environmental toxicants, causing wide-spread disruption of metabolic fuctions of the human body, leading to death from end-stage liver diseases. The aim of this review is to systematically explore and record the potential of Bangladeshi ethnopharmacological plants to treat liver diseases with focus on their sources, constituents, and therapeutic uses, including mechanisms of actions (MoA). A literature survey was carried out using Pubmed, Google Scholar, ScienceDirect, and Scopus databases with articles reported until July, 2020. A total of 88 Bangladeshi hepatoprotective plants (BHPs) belonging to 47 families were listed in this review, including Euphorbiaceae, Cucurbitaceae, and Compositae families contained 20% of plants, while herbs were the most cited (51%) and leaves were the most consumed parts (23%) as surveyed. The effect of BHPs against different hepatotoxins was observed via upregulation of antioxidant systems and inhibition of lipid peroxidation which subsequently reduced the elevated liver biomarkers. Different active constituents, including phenolics, curcuminoids, cucurbitanes, terpenoids, fatty acids, carotenoids, and polysaccharides, have been reported from these plants. The hepatoameliorative effect of these constituents was mainly involved in the reduction of hepatic oxidative stress and inflammation through activation of Nrf2/HO-1 and inhibition of NF-κB signaling pathways. In summary, BHPs represent a valuable resource for hepatoprotective lead therapeutics which may offer new alternatives to treat liver diseases.

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Ursolic acid: A natural preventive aesculapian for environmental hepatic ailments

Cited by 5 publications

References 1 publication

Triterpenic Acid Amides as a Promising Agent for Treatment of Metabolic Syndrome

Triterpenic Acid Amides as a Promising Agent for Treatment of Metabolic Syndrome

A comprehensive review on phytochemistry, molecular pharmacology, clinical and translational outfit of Ocimum sanctum L.

Hepatoprotective Plants from Bangladesh: A Biophytochemical Review and Future Prospect

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