A comprehensive review on phytochemistry, molecular pharmacology, clinical and translational outfit of Ocimum sanctum L.

Pradhan, Deepak; Biswasroy, Prativa; Halder, Jitu; Cheruvanachari, Priya; Dubey, Debasmita; Kumar, Vineet; Kar, Biswakanth; Kar, Dattatreya; Rath, Goutam; Ghosh, Goutam

doi:10.1016/j.sajb.2022.07.037

Cited by 3 publications

(3 citation statements)

References 102 publications

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“…Eugenol can also repair oxidative damage, inhibit cancer-causing mutations, and eliminate damaged molecules [ 164 , 165 , 166 ]. The antioxidant properties of eugenol can be inferred through its mechanism of reducing free radicals by the provided H-atoms [ 167 ].…”

Section: Antioxidant Potentialmentioning

confidence: 99%

An Update on the Therapeutic Anticancer Potential of Ocimum sanctum L.: “Elixir of Life”

et al. 2023

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In most cases, cancer develops due to abnormal cell growth and subsequent tumour formation. Due to significant constraints with current treatments, natural compounds are being explored as potential alternatives. There are now around 30 natural compounds under clinical trials for the treatment of cancer. Tulsi, or Holy Basil, of the genus Ocimum, is one of the most widely available and cost-effective medicinal plants. In India, the tulsi plant has deep religious and medicinal significance. Tulsi essential oil contains a valuable source of bioactive compounds, such as camphor, eucalyptol, eugenol, alpha-bisabolene, beta-bisabolene, and beta-caryophyllene. These compounds are proposed to be responsible for the antimicrobial properties of the leaf extracts. The anticancer effects of tulsi (Ocimum sanctum L.) have earned it the title of “queen of herbs” and “Elixir of Life” in Ayurvedic treatment. Tulsi leaves, which have high concentrations of eugenol, have been shown to have anticancer properties. In a various cancers, eugenol exerts its antitumour effects through a number of different mechanisms. In light of this, the current review focuses on the anticancer benefits of tulsi and its primary phytoconstituent, eugenol, as apotential therapeutic agent against a wide range of cancer types. In recent years, tulsi has gained popularity due to its anticancer properties. In ongoing clinical trials, a number of tulsi plant compounds are being evaluated for their potential anticancer effects. This article discusses anticancer, chemopreventive, and antioxidant effects of tulsi.

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Section: Antioxidant Potentialmentioning

confidence: 99%

An Update on the Therapeutic Anticancer Potential of Ocimum sanctum L.: “Elixir of Life”

et al. 2023

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“…O. basilicum has anti-in ammatory, antipyretic, anticancer, and neuroprotective properties of antimicrobial and cardioprotective agents (Beltrán-Noboa et al, 2022; Chanthavong et al, 2021;Kayathiri et al, 2022;Kustiati et al, 2022;Yadav et al, 2022). The stems and leaves of O. basilicum contain various secondary metabolites such as polyphenols, avonoids, amino acids, unsaturated fatty acids, terpenoids, saponins, tannins, and essential elements (vitamins and minerals) (Kumari et al, 2022;Pradhan et al, 2022). The plant's two main compounds (polyphenols and avonoids) are responsible for its various pharmacological activities, including anticancer, antioxidant, antimicrobial, and anti-in ammatory (Pradhan et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“…The stems and leaves of O. basilicum contain various secondary metabolites such as polyphenols, avonoids, amino acids, unsaturated fatty acids, terpenoids, saponins, tannins, and essential elements (vitamins and minerals) (Kumari et al, 2022;Pradhan et al, 2022). The plant's two main compounds (polyphenols and avonoids) are responsible for its various pharmacological activities, including anticancer, antioxidant, antimicrobial, and anti-in ammatory (Pradhan et al, 2022). In addition to basil leaves, Piper betle can also be a source of immunostimulant compounds since it contains compounds such as eugenol, chavicol, allylpyrocatechol, and chavibetol, which are antiseptic substances (Marchese et al, 2017;Sugumaran et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Increased non-specific immune activity of vaname shrimp Litopenaeus vannamei using a leaf flour mixture from Ocimum basilicum and Piper betle and their characteristic compounds

Harlina,

Rosmiati,

Hamdillah

et al. 2023

Preprint

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Immunostimulants are more suitable for improving the health of shrimp than using drugs in the prevention of diseases. This study evaluated the efficacy of bioactive compounds from Ocimum basilicum and Piper betle in increasing the non-specific immune response of Litopenaeus vannamei. Samples were collected directly from a traditional market. Shrimp was fed: O. basilicum leaf flour- and P. betle leaf flour-un-supplemented diet (P1), O. basilicum leaf flour (44.84 g/kg feed)-supplemented diet (P2), P. betle leaf flour (31.57 g/kg feed)-supplemented diet (P3), and O. basilicum leaf flour (22.42 g/kg feed)- and P. betle leaf flour (16.79 g/kg feed)-supplemented diet (P4). Phytochemical screening tests were conducted using commonly used chemical reagents, including Dragendorff, Meyer, and Liebermann-Burchard reagents. Supplementation with O. basilicum and P. betle (P4) significantly enhanced the shrimp’s immune response, namely the total hemocyte counts (THC), phagocytic activity (PA), phagocytic index (PI), and prophenoloxidase (proPO). The supplemented diet (P4) was synergistically able to improve shrimp health, with the highest values for THC (7.30 x 106 cells/mL), hyaline (61.33%), PA (84%), PI (2.19), and proPO (0.91). Flavonoids and alkaloids in the feed containing leaf flour from both plants were bioactive compounds suspected to be responsible for enhancing the immune response. These findings suggest that a leaf flour combination of O. basilicum and P. betle can be a new immunostimulant alternative to improve shrimp health for disease prevention.

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An Overview of Medicinal Plants: Drugs of Tomorrow

Ahirwar

2023

Stress-Responsive Factors and Molecular Farming in Medicinal Plants

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A comprehensive review on phytochemistry, molecular pharmacology, clinical and translational outfit of Ocimum sanctum L.

Cited by 3 publications

References 102 publications

An Update on the Therapeutic Anticancer Potential of Ocimum sanctum L.: “Elixir of Life”

An Update on the Therapeutic Anticancer Potential of Ocimum sanctum L.: “Elixir of Life”

Increased non-specific immune activity of vaname shrimp Litopenaeus vannamei using a leaf flour mixture from Ocimum basilicum and Piper betle and their characteristic compounds

An Overview of Medicinal Plants: Drugs of Tomorrow

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