Urolithiasis in Chronic Inflammatory Bowel Disease

Knudsen, L; Marcussen, Henrik Secher; Fleckenstein, Peter; Pedersen, Evelyn B.; Jarnum, S.

doi:10.3109/00365527809181917

Cited by 33 publications

(12 citation statements)

References 11 publications

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“…Previous studies have reported various risk factors for nephrolithiasis in patients with IBD, including lower age, male gender, long disease duration (>10 years), and bowel surgery [17,18]. In contrast, none of these factors were associated with urolithiasis in our study.…”

Section: Discussioncontrasting

confidence: 54%

Incidence and Risk Factors for Urolithiasis in Patients with Crohn's Disease

et al. 2015

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Background: The incidence of urinary tract calculi is thought to be higher in patients with inflammatory bowel disease (IBD) than that in the general population. However, few data are available about urolithiasis in patients with Crohn's disease (CD). We investigated the incidence of urolithiasis and the risk factors for urolithiasis in patients with CD. Methods: We examined the records of 387 patients with CD followed at Samsung Medical Center from July 2011 to June 2013. Evidence for the presence of calculi was obtained from radiologic findings (plain films, ultrasonography, or computed tomography), urinary colic symptoms, or a treatment history of urolithiasis after diagnosis of CD. Demographic variables, phenotype, concurrent medications, and previous CD-related surgery were analyzed. Results: Urinary tract calculi were found in 18 (4.7%) patients, which developed after the CD diagnosis. The incidence of urolithiasis in CD was 706 per 100,000 patient-years. Cox models with a time-dependent covariate showed that azathioprine (AZA)/6-mercaptopurine (6-MP) treatment (hazard ratio = 0.963; 95% CI: 0.931, 0.996; p = 0.030) was negatively associated with urolithiasis. Conclusions: The annual incidence rate of urolithiasis in patients with CD was 0.7%. AZA/6-MP therapy was associated with a low risk of urolithiasis in these patients.

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Section: Discussioncontrasting

confidence: 54%

Incidence and Risk Factors for Urolithiasis in Patients with Crohn's Disease

et al. 2015

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“…We provide an estimated risk of various surgical procedures with the highest risk attributable to ileo/ileo-caecal resection in CD (Fig 2). In Knudsen et al ileostomy per se increases the risk of nephrolithiasis [14], while other studies described surgery with resection of longer segments of the small intestine (50-100cm) as risk factors for kidney stones [36]. …”

Section: Discussionmentioning

confidence: 99%

Risk factors for gallstones and kidney stones in a cohort of patients with inflammatory bowel diseases

et al. 2017

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BackgroundGallstones and kidney stones are known complications of inflammatory bowel diseases (IBD). Risk factors have been insufficiently studied and explanatory studies date back up to 30 years. It remains unclear, whether improved treatment options also influenced risk factors for these complications.ObjectivesIdentifying risk factors for gallstones and kidney stones in IBD patients.MethodsUsing data from the Swiss Inflammatory Bowel Disease Cohort Study we assessed associations of diseases characteristics with gallstones and kidney stones in univariate and multivariate logistic regression analyses.ResultsOut of 2323 IBD patients, 104 (7.8%) Crohn’s disease (CD) and 38 (3.8%) ulcerative colitis (UC) patients were diagnosed with gallstones. Significant risk factors for gallstones were diagnosis of CD, age at diagnosis, disease activity and duration, NSAID intake, extra-intestinal manifestations and intestinal surgery. Kidney stones were described in 61 (4.6%) CD and 30 (3.0%) UC patients. Male gender, disease activity, intestinal surgery, NSAID usage and reduced physical activity were significant risk factors. Hospitalization was associated with gallstones and kidney stones. The presence of gallstones increased the risk for kidney stones (OR 4.87, p<0.001).ConclusionThe diagnosis of CD, intestinal surgery, prolonged NSAID use, disease activity and duration and bowel stenosis were significantly associated with cholecystonephrolithiasis in IBD.

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“…80,81 Prevalence varies with the type of IBD, the extent of the disease involvement, and prior surgeries. Stones are more common in ileocolonic (9% to 17%) than ileal (6% to 8%) or colonic (3% to 5%) disease.…”

Section: Nephrolithiasismentioning

confidence: 99%

Extraintestinal Manifestations of Inflammatory Bowel Diseases

Kethu¹

2006

Journal of Clinical Gastroenterology

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Inflammatory bowel diseases are associated with extraintestinal manifestations involving almost every organ system in the body. They occur in approximately 20% to 40% of patients with inflammatory bowel diseases. Immune-related and genetic mechanisms play an important role in the pathogenesis of these complications. Peripheral arthritis, erythema nodosum, and episcleritis respond to the treatment of the underlying intestinal inflammation, whereas axial arthropathy, pyoderma gangrenosum, and uveitis do not. Immunomodulator therapy, particularly with biologic agents has been shown to be effective in treating some of the extraintestinal manifestations. Early recognition and treatment are crucial in preventing major morbidity.

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Urolithiasis in Chronic Inflammatory Bowel Disease

Cited by 33 publications

References 11 publications

Incidence and Risk Factors for Urolithiasis in Patients with Crohn's Disease

Incidence and Risk Factors for Urolithiasis in Patients with Crohn's Disease

Risk factors for gallstones and kidney stones in a cohort of patients with inflammatory bowel diseases

Extraintestinal Manifestations of Inflammatory Bowel Diseases

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