Extraintestinal Manifestations of Inflammatory Bowel Diseases

Kethu, Sripathi R.

doi:10.1097/00004836-200607000-00003

Cited by 50 publications

(29 citation statements)

References 88 publications

(76 reference statements)

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“…It is important to stress the concept that IBD are often systemic diseases with an extraintestinal counterpart which points toward a pathogenesis linked to immunogenetic mechanisms. Indeed, in patients with PV, resolution of extraintestinal manifestations have been observed with treatment of bowel disease [2,5,7].…”

Section: Discussionmentioning

confidence: 99%

“…The strict association of PV with IBD (it is considered a clinical marker of ulcerative colitis) and its histologic features speak in favour of an immunological component to PV that shares pathogenetic similarities with IBD [7,8]. Also an abnormal immunologic response to a superimposition of bacterial infection or other unknown agents may play a pathogenetic role as it has been described for IBD [11].…”

Section: Introductionmentioning

confidence: 98%

“…PV was first described by Hallopeau in 1898 under the term of ''pyodermite vegetante'' and later in 1949 by McCarthy who coined the term ''pyostomatitis vegetans'' (reviewed in Hegarty et al [5]). Today these two entities are considered part of the spectrum of the same disease termed ''pyodermatitis-pyostomatitis vegetans'' and it is rare for them to be seen in the absence of IBD [4,[6][7][8]. Several authors, mainly in the dermatology field, consider PV to belong to the spectrum of pyoderma gangrenosum, a skin condition observed in association with IBD, vasculitis, rheumatoid arthritis and malignant hematologic diseases [9,10].…”

Section: Introductionmentioning

confidence: 99%

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Pyostomatitis Vegetans: Cellular Immune Profile and Expression of IL-6, IL-8 and TNF-α

Ficarra

Baroni

Massi

2009

Head and Neck Pathol

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The aim of this study was to investigate the cellular immune profile and the expression of IL-6, IL-8 and TNF-a in tissue biopsies of pyostomatitis vegetans (PV). Working hypothesis was that knowledge of the cellular immune profile and role of mediators such as IL-6, IL-8 AND TNF-alpha may contribute to a better understanding of the pathogenesis of this rare entity. Archival tissues from three patients with clinically and histologically confirmed PV were studied. Analysis of the immune profile of the cellular infiltrate and expression of IL-6 and IL-8 were evaluated by immunohistochemistry. ISH was performed to evaluate the expression of TNF-a. Biopsy tissues from erythema multiforme, recurrent aphthous stomatitis, lichen planus and normal buccal mucosa were analyzed as controls. All patients were affected by multiple mucosal ulcerations and yellow pustules mainly located in the vestibular, gingival and palatal mucosa. Histopathologically, all specimens showed ulcerated epithelium with characteristic intraepithelial and/or subepithelial microabscesses containing abundant eosinophils plus a mixed infiltrate composed of lymphocytes and neutrophils. Cellular immune profile of the inflammatory infiltrate revealed a predominance of T-lymphocytes, mainly of cytotoxic (CD3?/CD8?) phenotype, over B-cells. CD20? B-lymphocytes were also identified to a lesser degree among the lymphoid cells present in the lamina propria. Overexpression of IL-6 and TNF-a was found in both epithelial and inflammatory mononuclear cells. IL-8 expression was shown in the mononuclear cells scattered among the inflammatory infiltrate. Similar findings of overexpression of IL-6, IL-8 and TNF-a were, however, found in control tissues. In PV lesions, the inflammatory infiltrate shows a predominance of cytotoxic lymphocytes. Expression of IL-6, IL-8 and TNF-a, although not specific to PV, appears up-regulated thus these cytokines would represent a suitable therapeutic target. However, the complexity of the cytokine network and their numerous functions require further studies in order to confirm our findings.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Pyostomatitis Vegetans: Cellular Immune Profile and Expression of IL-6, IL-8 and TNF-α

Ficarra

Baroni

Massi

2009

Head and Neck Pathol

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“…The reported frequencies of EIMs in patients with IBD have varied between 6% and 47% (15)(16)(17)(18)(19)(20). Globally, about one-third of patients develop systemic manifestations (10).…”

Section: Discussionmentioning

confidence: 99%

Extraintestinal Manifestations of Inflammatory Bowel Diseases

Penchev¹

2017

Inflammatory Bowel Diseases

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“…Extra-intestinal inflammatory features, as peripheral arthritis, are common and NSAID prescription may occurs even as self medication (4,24) . Although the exact pathophysiology of exacerbation of colitis by non-steroidal anti-inflammatory drugs remains unresolved, it is likely that eicosanoids, through a colonic Prostaglandin E2 suppression accompanied or not by a compensatory increase in leukotriene B4, play a fundamental role (14) .…”

Section: Introductionmentioning

confidence: 99%

COMPARISON OF SELECTIVE AND NON SELECTIVE CYCLO-OXYGENASE 2 INHIBITORS IN EXPERIMENTAL COLITIS EXACERBATION: role of leukotriene B4 and superoxide dismutase

Breganó

Barbosa

Kadri

et al. 2014

Arq. Gastroenterol.

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-Context -Nonsteroidal anti-inflammatory drugs are considered one of the most important causes of reactivation of inflammatory bowel disease. With regard to selective cyclo-oxygenase 2 inhibitors, the results are controversial in experimental colitis as well as in human studies. Objective -The aim this study is to compare nonsteroidal anti-inflammatory drugs effects, selective and non selective cyclo-oxygenase 2 inhibitors, in experimental colitis and contribute to the understanding of the mechanisms which nonsteroidal anti-inflammatory drugs provoke colitis exacerbation. Methods -Six groups of rats: without colitis, with colitis, and colitis treated with celecoxib, ketoprofen, indometacin or diclofenac. Survival rates, hemoglobin, plasmatic albumin, colonic tissue of interleukin-1ß, interleukin-6, tumor necrosis factor alpha, prostaglandin E2, catalase, superoxide dismutase, thiobarbituric acid-reactive substances, chemiluminescence induced by tert-butil hydroperoxides, and tissue and plasmatic leukotriene B4 were determined. Results -The groups treated with diclofenac or indometacin presented lower survival rates, hemoglobin and albumin, higher tissue and plasmatic leukotriene B4 and tissue superoxide dismutase than the group treated with celecoxib. Ketoprofen presented an intermediary behavior between diclofenac/indometacin and celecoxib, concerning to survival rate and albumin. The groups without colitis, with colitis and with colitis treated with celecoxib showed leukotriene B4 and superoxide dismutase lower levels than the groups treated with nonselective cyclo-oxygenase 2 inhibitors. Conclusions -Diclofenac and indometacin presented the highest degree of induced colitis exacerbation with nonsteroidal anti-inflammatory drugs, celecoxib did not show colitis exacerbation, and ketoprofen presented an intermediary behavior between diclofenac/indometacin and celecoxib. These results suggest that leukotriene B4 and superoxide dismutase can be involved in the exacerbation of experimental colitis by nonselective nonsteroidal anti-inflammatory drugs. HEADINGS -Colitis. Non-steroidal anti-inflammatory agents. Eicosanoids. Oxidative stress.

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Extraintestinal Manifestations of Inflammatory Bowel Diseases

Cited by 50 publications

References 88 publications

Pyostomatitis Vegetans: Cellular Immune Profile and Expression of IL-6, IL-8 and TNF-α

Pyostomatitis Vegetans: Cellular Immune Profile and Expression of IL-6, IL-8 and TNF-α

Extraintestinal Manifestations of Inflammatory Bowel Diseases

COMPARISON OF SELECTIVE AND NON SELECTIVE CYCLO-OXYGENASE 2 INHIBITORS IN EXPERIMENTAL COLITIS EXACERBATION: role of leukotriene B4 and superoxide dismutase

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