Urine interleukin-18 and cystatin-C as biomarkers of acute kidney injury in critically ill neonates

Li, Yanhong; Fu, Chen-Lu; Zhou, Xiaofei; Xiao, Zhijian; Zhu, Xuyou; Jin, Meifang; Li, Xiaozhong; Feng, Xing

doi:10.1007/s00467-011-2072-x

Cited by 60 publications

(65 citation statements)

References 41 publications

(59 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…22 Moreover, this difference remained significant after adjustment for gestational Figure 1. Correlation between urinary angiotensinogen and gestational age or body weight.…”

Section: Comparison Of the Uagt Level In Neonates With Urinary Cysc-tmentioning

confidence: 89%

Early urinary angiotensinogen excretion in critically ill neonates

Wang

et al. 2015

J Renin Angiotensin Aldosterone Syst

Self Cite

View full text Add to dashboard Cite

Introduction: Urinary angiotensinogen is considered a reliable biomarker for intrarenal renin–angiotensin system activity. The aims of this study were to assess the urinary angiotensinogen level during the first day of life and to evaluate its correlation with renal function in critically ill neonates. Methods: Urinary angiotensinogen concentration during the first 24 hours of life was measured in 98 critically ill neonates. Neonatal renal function was assessed by urinary levels of cystatin-C, albumin and α1-microglobulin and urinary electrolyte excretion. Results: Urinary angiotensinogen level decreased with increasing gestational age and body weight in critically ill neonates (P<0.001). After adjustment for gestational age, urinary angiotensinogen level correlated with urinary fractional excretion of sodium and urinary levels of cystatin-C and α1-microglobulin. Multivariate linear regression identified a significant impact of urinary cystatin-C on urinary angiotensinogen level (P<0.001). Furthermore, urinary angiotensinogen was significantly increased in neonates with a urinary cystatin-C-to-creatinine ratio ⩾2500 ng/mg, which was the optimal cut-off value to predict acute kidney injury in our previous study. Conclusions: The urinary angiotensinogen level correlates with the overall maturity of renal function during the early postnatal period in critically ill neonates and an increased urinary angiotensinogen level might reflect renal injury in immature neonates.

show abstract

“…22 Moreover, this difference remained significant after adjustment for gestational Figure 1. Correlation between urinary angiotensinogen and gestational age or body weight.…”

Section: Comparison Of the Uagt Level In Neonates With Urinary Cysc-tmentioning

confidence: 89%

Early urinary angiotensinogen excretion in critically ill neonates

Wang

et al. 2015

J Renin Angiotensin Aldosterone Syst

Self Cite

View full text Add to dashboard Cite

show abstract

“…Different studies correlated renal functional status using pRIFLE criteria with renal biomarker (uCysC and uIL-18) 19,20 . As this biomarker are not widely available and costly, this study correlated renal impairment using pRIFLE criteria with Apgar score in asphyxiated neonate , so that renal impairment can be predicted early by low Apgar score in perinatal asphyxia.…”

Section: Discussionmentioning

confidence: 99%

Renal Functional Status of Asphyxiated Babies & its Correlation with Apgar Score

Saha¹,

Mollah

Afroz

et al. 2017

J. Bangladesh Coll. Phys.

View full text Add to dashboard Cite

Introduction: Kidney is the 2nd commonest affected organ as a consequence of asphyxia1. Most attention is given to prevent CNS damage and neurological sequel but hypoxic renal insult not only influences neonatal morbidity & mortality but may give rise to CKD. to assess the renal functional status of asphyxiated babies.Material & Methods: This cross sectional study was conducted in the Department of Neonatology & Department of Gynecology and Obstetrics, Dhaka Medical College Hospital during January 2012 to January 2013. A total of 150 inborn, term asphyxiated neonates with e 2.5 kg who had history of delayed or no cry with Apgar score <7 at 5 minutes were enrolled. Then, the cases were grouped into mild (AS: 6-7), moderate (AS: 4-5) and severe asphyxia (AS: 0-3) based on Apgar score. Forty eight neonates were excluded according to exclusion criteria. Finally, the renal functions were assessed among 102 neonates by measuring urine output 8 hourly and estimated creatinine clearance (eCCL) on the 3rd day o7f life using Schwartz formula (eCCl=Height (cm) ×.37/S.creatinine). Neonates with impaired renal function were further classified as stage-I (risk), II (injury), III (failure) using pRIFLE criteria. Data were analyzed by Chi-square & Pearson correlation coefficient test to find out correlation between Apgar scores and renal functional status.Results: Of the 102 cases studied, majority 48% were in moderate, 30.4% in mild and 21.6% in severely asphyxiated group. In the mild asphyxiated group 58.06% had normal renal function. However, the remaining cases 29.03% & 12.90% had stage I, stage II renal injury respectively and had no renal failure. In Moderately asphyxiated group, 26.53% had normal renal function & the remaining 32.65%, 34.69%, 6.1% had stage I, II, III renal injury respectively. None of the severely asphyxiated babies had normal renal function. However they had impaired renal function ranging from Stage I (27.27%), stage II (27.27%) & stage III (40.90%).Variable proportion of kidney injuries were noted among the asphyxiated neonates. The lower the Apgar score, the more severe the injuries and association between stages of kidney injuries and Apgar score was observed statistically significant (p<0.001). The renal functional status (eCCL) was also found positively correlated with low Apgar score (r=0.6, p<0.002).Conclusion: Variable functional impairment of kidneys was found among the asphyxiated neonates and the severity of impairment significantly correlated with low Apgar score.J Bangladesh Coll Phys Surg 2017; 35(3): 128-132

show abstract

“…18 In another study, a group of 62 critically ill neonates including eight term neonates with PA were recently evaluated for urinary biomarkers of AKI by Li et al 31 Urinary IL-18 was significantly higher in nonseptic critically ill neonates with AKI compared to controls. 31 Our study showed the presence of higher IL-18 levels in newborns with PA compared to controls. The sensitivity of uIL-18 was 93.3%; and the specificity was 90.5% in predicting AKI in newborns with PA.…”

Section: Discussionmentioning

confidence: 99%

Urinary markers of acute kidney injury in newborns with perinatal asphyxia^*

et al. 2016

View full text Add to dashboard Cite

Background: Acute kidney injury (AKI) affects up to 60% of severely asphyxiated neonates. The diagnosis of AKI can be and is further challenged by a lack of good biomarkers. We studied the role of novel markers for AKI, neutrophil gelatinase-associated lipocalin (NGAL), interleukin-8 (IL-18), Netrin-1 (NTN-1), and sodium hydrogen exchanger isoform 3 (NHE3) on development and early diagnosis of AKI in newborns with perinatal asphyxia (PA). Methods: Forty-one newborns with a diagnosis of PA (15 with AKI and 26 without AKI) and 20 healthy matched controls were involved to the study. Urinary samples were obtained on postnatal days 1 and 4 for patients with PA and on postnatal day 1 for the control subjects. AKI was defined using a serum creatininebased modification of the acute kidney injury network criteria. Results: The levels of NGAL, NTN-1, NHE3, and IL-18 on the first postnatal day urine samples were higher in patients compared to controls (p < 0.001, p <0.001, p <0.02, p <0.001, respectively). In patients with AKI, the levels of NGAL and IL-18 were higher when compared to patients without AKI (p ¼ 0.002, p <0.001, respectively). The levels of NTN-1 and NHE3 were similar in both groups. For the samples obtained on postnatal day 4, only NGAL levels were significantly higher in patients with AKI (p ¼ 0.004) compared to those without AKI. Conclusion: To our knowledge, this is the largest study, which evaluated the utility of urinary biomarkers in the diagnosis of AKI in newborns with PA. First day, urine NGAL and IL-18 levels have an important diagnostic power in such patients.

show abstract

Urine interleukin-18 and cystatin-C as biomarkers of acute kidney injury in critically ill neonates

Cited by 60 publications

References 41 publications

Early urinary angiotensinogen excretion in critically ill neonates

Early urinary angiotensinogen excretion in critically ill neonates

Renal Functional Status of Asphyxiated Babies & its Correlation with Apgar Score

Urinary markers of acute kidney injury in newborns with perinatal asphyxia^*

Contact Info

Product

Resources

About

Urine interleukin-18 and cystatin-C as biomarkers of acute kidney injury in critically ill neonates

Cited by 60 publications

References 41 publications

Early urinary angiotensinogen excretion in critically ill neonates

Early urinary angiotensinogen excretion in critically ill neonates

Renal Functional Status of Asphyxiated Babies & its Correlation with Apgar Score

Urinary markers of acute kidney injury in newborns with perinatal asphyxia*

Contact Info

Product

Resources

About

Urinary markers of acute kidney injury in newborns with perinatal asphyxia^*