Urinary Tract Lymphoma

Lewi, Henry; Stewart, Iain; Seywright, Morag; Fleming, Stewart; Deane, R. F.; Kyle, K. F.

doi:10.1111/j.1464-410x.1986.tb05419.x

Cited by 20 publications

(8 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lymphoma infiltration may affect the kidneys either primarily or secondarily [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15]. Other studies have reported a frequency of kidney involvement ranging from 0.8 to 49% [2,12,13,14, 17].…”

Section: Discussionmentioning

confidence: 99%

“…Renal involvement as the only site (primary renal lymphoma) is a rare entity [3,4,5,6,7,8,9,10]. Usually, renal infiltration is reported as a consequence of advanced disease [11,12,13,14,15]. …”

Section: Introductionmentioning

confidence: 99%

“…However, to our knowledge, there are few studies on the renal infiltration pattern or incidence in children [16,17,18]. The kidneys can be affected by NHL in several ways: by the mass effect of enlarged retroperitoneal lymph nodes, by obstructive uropathy caused by an intra-abdominal tumor, or by the metabolic effects of tumor lysis syndrome (TLS) [11,13,14,15,16]. Being aware of renal involvement on admission (either primarily or due to metastasis) is important for monitoring the patient as well as staging the disease.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Renal Involvement of Non-Hodgkin’s Lymphoma and Its Prognostic Effect in Childhood

Büyükpamukçu

Varan²,

Aydın³

et al. 2005

Nephron Clin Pract

View full text Add to dashboard Cite

Objective: To evaluate renal involvement in childhood lymphoma and define its prognostic effects. Patients and Methods: One hundred and four patients with non-Hodgkin’s lymphoma and renal involvement on admission to a single center between 1972 and 2003 were evaluated retrospectively. Blood urea nitrogen, serum creatinine, uric acid, electrolytes, and lactate dehydrogenase levels, as well as urinalysis, were evaluated. One or more of the following imaging methods were performed: intravenous urogram, ultrasound, computed tomography, and magnetic resonance imaging. The χ² test was used to compare the groups. The Kaplan-Meier survival method was used to calculate survival rates, and the log-rank test was used to compare groups with respect to survival. Survival rates were also compared in two different time periods (before 1991 and after 1991). Results: There were 76 boys and 28 girls with a median age of 6 (0.9–16) years. The renal infiltration pattern was nodular in 62 patients (59.6%) and diffuse in 40 patients (38.5%). Two patients had tumoral masses that originated from their kidneys (1.9%). Renal involvement was bilateral in 75 patients (72.1%); the remaining 29 patients had unilateral involvement. The overall survival rate was 42.5% with a median follow-up of 64 months. The factors that had a statistically significant impact on survival were high creatinine (p = 0.00001) and blood urea nitrogen levels (p = 0.0001), the onset of tumor lysis syndrome (p = 0.01), and the need for dialysis (p = 0.009). The survival rate was higher in the time period after 1991 (p = 0.01). Conclusion: Impaired renal function is a poor prognostic factor for non-Hodgkin’s lymphoma. Renal function should therefore be monitored closely. Renal dysfunction caused by direct tumoral involvement may complicate therapy and shorten survival.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Renal Involvement of Non-Hodgkin’s Lymphoma and Its Prognostic Effect in Childhood

Büyükpamukçu

Varan²,

Aydın³

et al. 2005

Nephron Clin Pract

View full text Add to dashboard Cite

show abstract

“…About 15-25% of malignant NHLs are primarily lo cated in extranodal sites [22,23], The mucosa-associated (MALT-type) NHLs are mainly found in the gastrointesti nal tract, in the region of the Waldeyer's tonsillar ring, as well as in the parotis [8,22,23], The genitourinary system usually shows a secondary involvement in advanced nodal NHL [17], as demonstrated by autopsy statistics in 10-60% of these cases, predominantly manifesting in the kidneys and testes [ 15,16,24,25]. With regard to primary extranodal lymphomas, only 2.7% are located in the geni tourinary system [24], and only rarely is the urethra involved: in immunocompetent patients we found only 4 Male Urethra cases of primary NHL in the urethra, all of them females, in spite of an intensive search of the literature so far [9][10][11][12].…”

Section: Discussionmentioning

confidence: 99%

“…In 1992 Mostofi et al [5] collected and reviewed about 600 cases of urethral carcinomas world-wide, con sisting of urothelial and squamous cell carcinomas and, rarely, papillary adenocarcinomas [6], Even more uncom mon is the occurrence of primary non-Hodgkin's lympho mas (NHLs) in the urethra [7], To our knowledge a prima ry extranodal manifestation of NHL in the urethra, i.e. of the mucosa-associated lymphoid tissue (MALT) type [8], has been described only in 4 female immunocompetent patients [9][10][11][12], A probable secondary involvement of a nodal NHL in the urethra of 2 further cases, as reported in the patients' histories [13,14], seems to be a relatively Received: September 15,1994 Accepted after revision: March 8,1995 more frequent event in the urinary tract than its primary occurrence [15][16][17], Additionally in male AIDS patients 2 recent case reports of urethral NHL were published [18,19], which may be related to the higher lymphoma inci dence in immunodeficient persons with HIV infection , In the present report a primary extranodal NHL of the male urethra is described, and it seems to be the first documented case (to our knowledge) in a male patient without an immunodeficiency status. …”

mentioning

confidence: 99%

Primary Non-Hodgkin’s Lymphoma of the Male Urethra

Hofmockel¹,

Dämmrich²,

García³

et al. 1995

Urol Int

View full text Add to dashboard Cite

Approximately 15-25% of malignant non-Hodgkin’s lymphomas (NHLs) are primarily extranodal and only 2.7% of these are located in the genitourinary tract. Only a few particular cases of primary manifestation of NHL in the urethra have been described, most of them in female patients, whereas a secondary involvement occurs more frequently . In the present case a high-grade malignant NHL of the B-cell type was located in the urethra of a 29-year-old male patient. No other manifestations of NHL could be found. After surgical removal of the urethral neoplasm the patient was treated with combined chemotherapy (6 cycles of the CHOP scheme). Thereafter, reconstruction of the urethra by the island flap method of Duckett was carried out. Two years after diagnosis the patient is alive and in complete remission with good functional and cosmetic results of surgery and a normal sexual life.

show abstract

Malignant lymphoma involving the prostate

Bostwick

Iczkowski

Amin

et al. 1998

Cancer

130

149

View full text Add to dashboard Cite

BACKGROUND Malignant lymphoma involving the prostate is rare, and to the authors' knowledge the factors determining patient outcome have not been studied in a large series. METHODS The authors evaluated the clinical and pathologic findings in 60 cases of non‐Hodgkin's lymphoma and 2 cases of Hodgkin's lymphoma involving the prostate. A variety of clinical and histologic findings were considered as factors predictive of patient outcome. RESULTS Lymphoma tended to occur in elderly men, with a mean age at diagnosis of 62 years (range, 5‐89 years), although 6 patients were age < 40 years (ages 5, 19, 30, 32, 38, and 38 years, respectively). Clinical signs and symptoms were due to lower urinary tract obstruction. Twenty‐two patients (35%) presented with primary extranodal lymphoma of the prostate with a variety of histologic subtypes, including small lymphocytic (4 patients); follicular center cell, diffuse, small cell (2 patients); follicular center cell, Grade 1 (according to the revised European‐American classification (small cleaved) (1 patient); Grade 2 (mixed) (1 patient); diffuse large B‐cell (12 patients); and high grade B‐cell lymphoma, Burkitt‐like (2 patients). At the time of presentation, none of these patients had hepatosplenomegaly, inguinal lymphadenopathy, or an abnormal complete blood count. Thirty other patients (48%) with previously documented lymphoma at other sites developed prostatic involvement; these secondary prostatic lymphomas displayed a variety of subtypes, including small lymphocytic (8 patients, all with concomitant leukemia); follicular center cell lymphoma, diffuse, small cell (2 patients); follicular center, Grade 1 (small cell) (1 patient); follicular center, Grade 2 (1 patient); diffuse large B‐cell (11 patients); peripheral T‐cell lymphoma (2 patients); high grade B‐cell lymphoma, Burkitt‐like (1 patient); Burkitt's lymphoma (1 patient); Hodgkin's lymphoma (nodular sclerosing [1 patient] and mixed cellularity [1 patient]); and unknown (1 patient). Ten cases were not classifiable as primary or secondary lymphomas. Twenty‐five patients died of malignant lymphoma, 14 died of unknown or other causes, 18 patients were alive 12‐20 months after diagnosis (8 primary and 10 secondary tumors; 3 had persistent lymphoma; all treated since 1981), and 5 were lost to follow‐up. Lymphoma specific survival was 64% at 1 year (95% confidence interval [CI], 51‐80%), 50% at 2 years (95% CI, 36‐68%), 33% at 5 years, 33% at 10 years, and 16% at 15 years. There was no difference in median survival after diagnosis of prostatic involvement between primary and secondary lymphoma (23 months vs. 28 months, respectively) or among histologic types. CONCLUSIONS Although malignant lymphoma involving the prostate is rare, it should be considered in the differential diagnosis of lower urinary tract obstruction, particularly in patients with a previous history of lymphoma. Cancer 1998;83:732‐738. © 1998 American Cancer Society.

show abstract

Urinary Tract Lymphoma

Cited by 20 publications

References 9 publications

Renal Involvement of Non-Hodgkin’s Lymphoma and Its Prognostic Effect in Childhood

Renal Involvement of Non-Hodgkin’s Lymphoma and Its Prognostic Effect in Childhood

Primary Non-Hodgkin’s Lymphoma of the Male Urethra

Malignant lymphoma involving the prostate

Contact Info

Product

Resources

About