Urinary phthalate monoesters concentration in couples with infertility problems

Tranfo, Giovanna; Caporossi, Lidia; Paci, Enrico; Aragona, Cesare; Romanzi, Daniela; Carolis, Caterina De; Rosa, Mariangela De; Capanna, Silvia; Papaleo, Bruno; Pera, Alessandra

doi:10.1016/j.toxlet.2011.11.033

Cited by 86 publications

(39 citation statements)

References 30 publications

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“…In recent years, several studies have demonstrated a relationship between infertility and DEHP [29,30]. The harmful contribution of DEHP to infertility, especially to female reproduction, has been hard to ignore.…”

Section: Discussionmentioning

confidence: 99%

Effects of DEHP on endometrial receptivity and embryo implantation in pregnant mice

Li¹,

Yu²,

Gao³

et al. 2012

Journal of Hazardous Materials

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Section: Discussionmentioning

confidence: 99%

Effects of DEHP on endometrial receptivity and embryo implantation in pregnant mice

Li¹,

Yu²,

Gao³

et al. 2012

Journal of Hazardous Materials

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“…In a small case control study comprising 56 couples with and 56 without infertility, infertile partners excreted higher concentrations of five phthalate metabolites in comparison to fertile partners (22). A cohort study comprising couples planning pregnancy and prospectively followed for six cycles reported that mEHP but not five other phthalates was significantly associated with approximately a three-fold increased odds of pregnancy loss (23).…”

Section: Introductionmentioning

confidence: 97%

Urinary bisphenol A, phthalates, and couple fecundity: the Longitudinal Investigation of Fertility and the Environment (LIFE) Study

Louis

Sundaram

Sweeney

et al. 2014

Fertility and Sterility

156

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Objective Assess the relation between environmental chemicals and couple fecundity or time-to-pregnancy (TTP). Design Prospective cohort. Setting Couples completed interviews and anthropometric assessments and provided urine specimens for quantification of bisphenol A (BPA) and 14 phthalate metabolites using high-performance liquid chromatography with electrospray triple-quadrupole mass spectrometer. Women recorded menstruation and pregnancy test results in daily journals. Couples were followed until a positive hCG pregnancy test or 12 cycles without pregnancy. Patients 501 couples recruited upon discontinuing contraception to become pregnant, 2005–2009. Interventions None Main Outcome Fecundability odds ratios (FORs) and 95% confidence intervals (CIs) were estimated for each partner’s chemical concentrations adjusting for age, body mass index, cotinine, creatinine, and research site while accounting for time off contraception. Results Neither female nor male BPA concentration was associated with TTP (FOR 0.98; 95% CI 0.86, 1.13 and FOR 1.04; 95% CI 0.91, 1.18, respectively). Men’s urinary concentrations of monomethyl, mono-n-butyl and monobenzyl phthalates were associated with a longer TTP (FOR=0.80, 95% CI 0.70, 0.93; FOR=0.82, 0.70, 0.97; and FOR=0.77, 0.65–0.92, respectively). Conclusions Select male but not female phthalate exposures were associated with an approximately 20% reduction in fecundity underscoring the importance of assessing both partners’ exposure to minimize erroneous conclusions.

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“…In Generation R, a large pregnancy cohort study conducted in the Netherlands, occupational exposure to phthalates was assessed using a job-exposure matrix, and was reported to be suggestive of longer TTP (22,23). In Italy, concentrations of several phthalate metabolites were assessed in 56 infertile couples from an ART center, and they were found to be significantly higher than in the control group of fertile couples (24). Recently, in the LIFE Study, no phthalate metabolite in female urine was statistically associated with a longer TTP, although one metabolite [mono (3-carboxypropyl) phthalate] was associated with a shorter TTP.…”

mentioning

confidence: 99%

Female exposure to phenols and phthalates and time to pregnancy: the Maternal-Infant Research on Environmental Chemicals (MIREC) Study

Vélez

Arbuckle

Fraser

2015

Fertility and Sterility

110

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Urinary phthalate monoesters concentration in couples with infertility problems

Cited by 86 publications

References 30 publications

Effects of DEHP on endometrial receptivity and embryo implantation in pregnant mice

Effects of DEHP on endometrial receptivity and embryo implantation in pregnant mice

Urinary bisphenol A, phthalates, and couple fecundity: the Longitudinal Investigation of Fertility and the Environment (LIFE) Study

Female exposure to phenols and phthalates and time to pregnancy: the Maternal-Infant Research on Environmental Chemicals (MIREC) Study

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