Effects of DEHP on endometrial receptivity and embryo implantation in pregnant mice

Li, Rui; Yu, Chao; Gao, Rufei; Liu, Xueqing; Lu, Jing; Zhao, Lijing; Chen, Xuemei; Ding, Yubin; Wang, Yingxiong; He, Junlin

doi:10.1016/j.jhazmat.2012.09.038

Cited by 66 publications

(36 citation statements)

References 46 publications

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“…Unfortunately, we do not have genetic data available in the ENDO Study. Recent experimental evidence using mice revealed that increasing doses of DEHP compromised endometrial receptivity and the number of implantation sites (53) suggesting a possible adverse effect on the endometrium or hormonal signaling.…”

Section: Discussionmentioning

confidence: 99%

Bisphenol A and phthalates and endometriosis: the Endometriosis: Natural History, Diagnosis and Outcomes Study

Louis

Peterson

Chen

et al. 2013

Fertility and Sterility

120

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Objective To explore the relation between bisphenol A and 14 phthalate metabolites and endometriosis. Design Matched cohort design. Setting 14 clinical centers in Salt Lake City, Utah or San Francisco, California, 2007–2009. Patients The operative cohort comprised 495 women undergoing laparoscopy/laparotomy, while the population cohort comprised 131 women matched on age and residence. Interventions None Main Outcome Measure(s) Surgically visualized or pelvic magnetic resonance imaging (MRI) diagnosed endometriosis in the two cohorts, respectively. Results Odds ratios (OR) and 95% confidence intervals (CIs) were estimated using logistic regression adjusting for age, body mass index and creatinine. In the population cohort, six phthalate metabolites (mBP, mCMHP, mECPP, mEHP, mEHHP, and mEOHP) were significantly associated with approximately a twofold increase in the odds of an endometriosis diagnosis. Two phthalates were associated with endometriosis in the operative cohort when restricting to visualized and histologic endometriosis (mOP; OR=1.38; 95% CI 1.10, 1.72), or when restricting comparison women to those with a postoperative diagnosis of a normal pelvis (mEHP; OR=1.35; 95% CI 1.03, 1.78). Conclusions Select phthalates were associated with higher odds of an endometriosis diagnosis for women with MRI diagnosed endometriosis. The lack of consistency of findings across cohorts underscores the impact of methodology on findings.

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Section: Discussionmentioning

confidence: 99%

Bisphenol A and phthalates and endometriosis: the Endometriosis: Natural History, Diagnosis and Outcomes Study

Louis

Peterson

Chen

et al. 2013

Fertility and Sterility

120

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“…Up to now, the effects of different TCM treatments, including jiantai liquid (Liu et al, 2006), Kunbao granule (Zhou et al, 2006) and so on, in human and other mammals on both endometrial receptivity and embryonic implantation are still unclear. In the present comparison study, we demonstrated for the first time that, between TCM groups and the model groups in mice (OS group and OS + TCM group; EID group and EID + TCM group), differences arose both in the expression of endometrial LIF and integrin ␤3 subunit during the implantation window.…”

Section: Discussionmentioning

confidence: 99%

Extracts from a traditional Chinese herbal remedy (Zhuyun recipe) improve endometrial receptivity in mice with embryonic implantation dysfunction and ovulation stimulation

Yang

Yin

2011

Journal of Ethnopharmacology

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“…From the clinical point of view, implantation failure is a major reproductive disorder . The normal implantation process is divided into three successive phases termed apposition, attachment, and penetration; these are tightly regulated by implantation‐related genes, including HB‐EGF , P53 , ErbB1, and COX1/2 .…”

Section: Introductionmentioning

confidence: 99%

Melatonin‐related genes expressed in the mouse uterus during early gestation promote embryo implantation

Wang

et al. 2015

Journal of Pineal Research

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Melatonin, a superior antioxidant, is an important molecule which regulates female reproduction due to its receptor-mediated and receptor-independent antioxidant actions. In this study, we investigated the effect of melatonin on early gestation in a mouse model. During early gestation, the expression of the melatonin's rate-limiting enzyme, AANAT, gradually increased - in the uterus while the MT2 melatonin receptor was only expressed at day 2 of gestation and no MT1 was detected. Based on these findings, we conducted a melatonin injection experiment which demonstrated that 15 mg/kg melatonin significantly improved the number of implantation sites and the litter size. Also, the blastocyst and uterus were collected to identify the local action of melatonin. In the melatonin-treated mice, the endometrium was thicker than in the control mice; melatonin also caused an increase in density of uterine glands, and the uterine gland index (UGI) was significantly elevated over that of the control. Serum steroid hormone measurements revealed that at day 6 of gestation (postimplantation), melatonin significantly downregulated the E2 level, with no obvious effects on progesterone. Gene expression assay revealed that melatonin significantly upregulated expression of HB-EGF, a crucial gene involved in implantation as well as its receptor ErbB1 in the blastocyst. In addition, PRA, an important gene which influences the decidual response and luminal cell differentiation, p53, which regulates uterine through leukaemia inhibitory factor (LIF), were both increased after melatonin treatment. These data suggest that melatonin and its MT2 receptor influence early gestation. Exogenous melatonin treatment can improve mouse embryo implantation and litter size, which may have important applications in human reproductive health and animal husbandry.

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Effects of DEHP on endometrial receptivity and embryo implantation in pregnant mice

Cited by 66 publications

References 46 publications

Bisphenol A and phthalates and endometriosis: the Endometriosis: Natural History, Diagnosis and Outcomes Study

Bisphenol A and phthalates and endometriosis: the Endometriosis: Natural History, Diagnosis and Outcomes Study

Extracts from a traditional Chinese herbal remedy (Zhuyun recipe) improve endometrial receptivity in mice with embryonic implantation dysfunction and ovulation stimulation

Melatonin‐related genes expressed in the mouse uterus during early gestation promote embryo implantation

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