Female exposure to phenols and phthalates and time to pregnancy: the Maternal-Infant Research on Environmental Chemicals (MIREC) Study

Vélez, Maria P.; Arbuckle, Tye E.; Fraser, William D.

doi:10.1016/j.fertnstert.2015.01.005

Cited by 110 publications

(100 citation statements)

References 61 publications

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“…Similar problems with attempting a PI(E)CO review can be observed with the two available studies on exposure to TCS and time to pregnancy (Velez et al 2015;Smarr et al 2017). The results from these studies were inconsistent, as were the study design and exposure assessment approaches.…”

Section: Consistency Of Methods Results and Reporting Across Studiesmentioning

confidence: 75%

“…While we did not formally assign quality tiers for steps taken to avoid sample contamination and to ensure analyte stability, we note that only two studies specifically reported the incorporation of field and lab blanks in their methods (Velez et al 2015;Ashley-Martin et al 2016). None of the studies offered documentation of analyte stability.…”

Section: Exposure Assessmentmentioning

confidence: 98%

“…Of the 43 studies, 24 were conducted in North America (Wolff et al , 2010(Wolff et al , 2015Clayton et al 2011;You et al 2011;Buttke et al 2012;Savage et al 2012Savage et al , 2014Koeppe et al 2013;Lankester et al 2013;Buser et al 2014;Spanier et al 2014;Adgent and Rogan 2015;Li et al 2015;Ihde et al 2015;Shiue 2015aShiue , 2015bVelez et al 2015;Ashley-Martin et al 2016;Buckley et al 2016;Poole et al 2016;Scinicariello and Buser 2016;Smarr et al 2017;Geer et al 2017), two studies in the Caribbean (Watkins et al 2015;Aker et al 2016), 10 studies in Europe (Allmyr et al 2009;Chevrier et al 2012;Philippat et al 2012Philippat et al , 2014Bertelsen et al 2013;Buhl et al 2014;Den Hond et al 2013, 2015Geens et al 2015;Lassen et al 2016), four in Asia (Chen et al 2013;Wang et al 2015;Xue et al 2015;Zhu et al 2016), and three in Australia (Cullinan et al 2012(Cullinan et al , 2015a…”

Section: Overview Of Studiesmentioning

confidence: 99%

“…The cohort study by Smarr et al (2017) was assigned to Tier 1 for exposure characterization as described previously. The cross-sectional studies by Wang et al (2015) and Velez et al (2015) were assigned to Tier 3 with respect to exposure assessment methods, as they both relied on one TCS measurement with no assessment of error in exposure characterization. Wang et al (2015) examined urine TCS concentrations in women who had medically unexplained spontaneous abortion in mid-gestation (cases) and in women who had no history of spontaneous abortion and had at least one living child (controls).…”

Section: Female Reproductive Endpointsmentioning

confidence: 99%

“…As noted earlier, a methodological strength of the Smarr et al (2017) study is the ability to examine the extent of exposure assessment error by comparing the overall result to the result of a separate analysis restricted to couples with a shorter time to pregnancy. Velez et al (2015) conducted a cross-sectional analysis that examined the association between urinary TCS measured during first trimester of pregnancy and time to pregnancy (ascertained by recall). The results were mixed; only one analysis, which used urinary TCS levels as a binary variable (using 75th percentile as the cutoff), demonstrated a statistically significant association with longer time to pregnancy; however, this result was not confirmed when TCS was treated as a continuous or ordinal variable.…”

Section: Female Reproductive Endpointsmentioning

confidence: 99%

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Systematic review of the literature on triclosan and health outcomes in humans

Goodman

Naiman

LaKind

2017

Critical Reviews in Toxicology

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The ability of epidemiologic evidence to inform regulatory decisions is largely dependent on the coherence and quality of the published literature. This systematic review examines the quality and consistency of studies assessing health outcomes associated with exposure to triclosan (TCS), an antimicrobial chemical with a short physiologic half-life. We used elements of the Biomonitoring, Environmental Epidemiology, and Short-Lived Chemicals instrument to evaluate aspects of study quality. Each methodological domain -overall design, exposure assessment, and data analysis -was categorized according to three tiers where Tier 1 indicated the highest quality. We also examined consistency of methods, results and reporting as considerations for weight of evidence (WOE) assessment. Studies were considered sufficiently comparable if they addressed the same or similar research questions. Forty-two studies met the criteria for inclusion. Only one randomized cross-over clinical trial of TCS was assigned to Tier 1 for all three domains. Most other studies were assigned to Tier 3 for at least one domain. Although the available literature examined more than 100 different health endpoints and reported hundreds of different measures of association, few studies were considered comparable. For reported measures of association, most were not significantly different from the null; the few statistically significant results represented isolated findings without a discernable across-or within-study pattern. We conclude that the current body of epidemiologic literature does not allow a meaningful WOE assessment due to methodological limitations of individual studies and lack of inter-study consistency. On the other hand, methodologically stronger studies may be used to inform future research. ARTICLE HISTORY

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Section: Consistency Of Methods Results and Reporting Across Studiesmentioning

confidence: 75%

Section: Exposure Assessmentmentioning

confidence: 98%

Section: Overview Of Studiesmentioning

confidence: 99%

Section: Female Reproductive Endpointsmentioning

confidence: 99%

Section: Female Reproductive Endpointsmentioning

confidence: 99%

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Systematic review of the literature on triclosan and health outcomes in humans

Goodman

Naiman

LaKind

2017

Critical Reviews in Toxicology

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Developmental toxicity induced by triclosan exposure in zebrafish embryos

Iannetta

Caioni

Vito

et al. 2022

Birth Defects Research

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Objectives: The present study aimed to investigate the acute toxicity and the developmental alterations induced by triclosan (TCS) exposure in zebrafish early-life stages using fish embryo acute toxicity tests as a methodological approach.Material and Methods: Zebrafish embryos were exposed to five concentrations of TCS and the four lethal alterations were daily recorded to determine the toxicological endpoints of acute toxicity. Furthermore, sublethal alterations were recorded to assess the effect of exposure concentrations on zebrafish embryo's development.Results: The TCS toxicity was determined at 96 h of exposure as lethal concentration 10, lethal concentration 20, lethal concentration 50, lowest observed effects concentration, and no observed effects concentration, reported the following values: 168, 197.2, 267.8, 300, and 200 μg/L. Exposed larvae showed a delay in hatching rate and developed sublethal alterations including reduced blood flow, pericardial oedemata, reduced heartbeat, blood congestion, and craniofacial malformations. The number of zebrafish larvae developing cardiovascular alterations changed according to the tested concentrations and time of evaluation. Conclusion:The data confirmed the developmental toxicity of TCS on aquatic organisms and the sublethal alterations developed by zebrafish larvae, indicated its cardiotoxicity and neurotoxicity. Moreover, the developmental toxicity was strongly influenced by the concentration tested and the number of survived zebrafish developing this alteration varying according to the time of exposure. K E Y W O R D S aquatic toxicology, in vivo model, personal care products toxicity, sublethal alterations 1 | INTRODUCTION Triclosan (5-chloro-2-(2,4-dichloro phenoxy)phenol; TCS) is a nonionic, broad-spectrum antimicrobial used as ingredient in disinfectants, soap, detergent, toothpaste, mouthwash, fabric, deodorant, shampoo, and plastic additives, in addition to innumerable other personal care, veterinary, industrial, and household products (Dann &

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The effects of endocrine‐disrupting chemicals on ovarian‐ and ovulation‐related fertility outcomes

Land

Miller

Fugate

et al. 2022

Molecular Reproduction Devel

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Exposure to endocrine‐disrupting chemicals (EDCs) is unavoidable, which represents a public health concern given the ability of EDCs to target the ovary. However, there is a large gap in the knowledge about the impact of EDCs on ovarian function, including the process of ovulation. Defects in ovulation are the leading cause of infertility in women, and EDC exposures are contributing to the prevalence of infertility. Thus, investigating the effects of EDCs on the ovary and ovulation is an emerging area for research and is the focus of this review. The effects of EDCs on gametogenesis, uterine function, embryonic development, and other aspects of fertility are not addressed to focus on ovarian‐ and ovulation‐related fertility issues. Herein, findings from epidemiological and basic science studies are summarized for several EDCs, including phthalates, bisphenols, per‐ and poly‐fluoroalkyl substances, flame retardants, parabens, and triclosan. Epidemiological literature suggests that exposure is associated with impaired fecundity and in vitro fertilization outcomes (decreased egg yield, pregnancies, and births), while basic science literature reports altered ovarian follicle and corpora lutea numbers, altered hormone levels, and impaired ovulatory processes. Future directions include identification of the mechanisms by which EDCs disrupt ovulation leading to infertility, especially in women.

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Female exposure to phenols and phthalates and time to pregnancy: the Maternal-Infant Research on Environmental Chemicals (MIREC) Study

Cited by 110 publications

References 61 publications

Systematic review of the literature on triclosan and health outcomes in humans

Systematic review of the literature on triclosan and health outcomes in humans

Developmental toxicity induced by triclosan exposure in zebrafish embryos

The effects of endocrine‐disrupting chemicals on ovarian‐ and ovulation‐related fertility outcomes

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