Urinary pH reflects dietary acid load in patients with type 2 diabetes

Miki, Akane; Hashimoto, Yoshitaka; Tanaka, Muhei; Kobayashi, Yukiko; Wada, Satoshi; Kuwahata, Masashi; Kido, Yasutoshi; Yamazaki, Masahiro; Fukui, Michiaki

doi:10.3164/jcbn.16-118

Cited by 17 publications

(11 citation statements)

References 30 publications

(48 reference statements)

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“…Forth, we don’t consider the influence of participant’s dietary. ( 43 , 44 ) Lastly, the generalizability of our study to non-Japanese populations is uncertain.…”

Section: Discussionmentioning

confidence: 93%

Nonalcoholic fatty liver disease remission in men through regular exercise

Osaka

Hashimoto

Hamaguchi³

et al. 2018

J. Clin. Biochem. Nutr.

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Recent cross-sectional and randomized controlled studies of small sample sizes revealed that regular exercise is effective for improving nonalcoholic fatty liver disease. However, there has been no large-scale longitudinal study addressing the effect of regular exercise on remission of nonalcoholic fatty liver disease. Thus, we investigated the impact of exercise on the natural history of nonalcoholic fatty liver disease. We analyzed 1,010 (860 men and 150 women) Japanese participants who received health checkups repeatedly over 10 years by a historical cohort study and were diagnosed with nonalcoholic fatty liver disease at baseline. Regular exercise was defined as participating in any kind of sports at least once a week. Nonalcoholic fatty liver disease was diagnosed by ultrasonographic images. During 10 years of follow-up, remission of nonalcoholic fatty liver disease was observed in 46.0% (396/860) of men and 48.7% (73/150) of women. In men, the adjusted hazard ratio of regular exercise for remission of nonalcoholic fatty liver disease was 1.46 (95% confidence interval 1.10–1.95, p = 0.010). However, this was not significant in women. Exercise at least once a week is implicated in the remission of nonalcoholic fatty liver disease in men.

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“…Forth, we don’t consider the influence of participant’s dietary. ( 43 , 44 ) Lastly, the generalizability of our study to non-Japanese populations is uncertain.…”

Section: Discussionmentioning

confidence: 93%

Nonalcoholic fatty liver disease remission in men through regular exercise

Osaka

Hashimoto

Hamaguchi³

et al. 2018

J. Clin. Biochem. Nutr.

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“…We defined carbohydrate to fiber ratio as carbohydrate (g)/fiber intake (g). We also calculated potential renal acid load score (PRAL; mEq/day) and net endogenous acid production score (NEAP; mEq/day) [16], which are known as makers of dietary acid load [17]. …”

Section: Methodsmentioning

confidence: 99%

Intake of Carbohydrate to Fiber Ratio Is a Useful Marker for Metabolic Syndrome in Patients with Type 2 Diabetes: A Cross-Sectional Study

et al. 2018

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Background/Aims: The effect of low carbohydrate diet on human health is still controversial. Whole grain, which is carbohydrate rich in fiber, has protective effects on human health. Thus, we assumed that intake of carbohydrate to fiber ratio has an important role in human health. Methods: This is a post-hoc analysis of a cross-sectional study of 164 patients with type 2 diabetes. Habitual food and nutrient intake were assessed and estimated by a self-administered diet history questionnaire. Intake of carbohydrate to fiber ratio was defined as carbohydrate (g)/fiber intake (g). Logistic regression analyses were performed to reveal the association between intake of carbohydrate to fiber ratio and metabolic syndrome (MetS). Results: Intake of carbohydrate to fiber ratio has closely associated with metabolic parameters, including triglycerides (r = 0.21, p = 0.007) and high-density lipoprotein cholesterol (r = –0.23, p = 0.003). Intake of carbohydrate to fiber ratio was associated with MetS (OR 1.06 [95% CI 1.00–1.13], p = 0.047) after adjusting for covariates, whereas carbohydrate intake (1.00 [0.99–1.01], p = 0.752) or carbohydrate energy/total energy (1.00 [0.94–1.07], p = 0.962) was not associated with MetS. Conclusions: Intake of carbohydrate to fiber ratio was associated with MetS, whereas carbohydrate intake was not.

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“…(23) Based on the mechanism, many biomarkers for the prediction of T2D are proposed. (24,25) Among them, HbA1c is a gold standard for the evaluation of glucose tolerance since it reflects the glucose levels directly in the blood, although it is not a sensitive marker. Insulin resistance is characterized by increased glucose uptake resulting from decreased peripheral muscle glucose uptake.…”

Section: Discussionmentioning

confidence: 99%

Utility of hemoglobin A1c in detecting risk of type 2 diabetes: comparison of hemoglobin A1c with other biomarkers

Umeno

Yoshida

2019

J. Clin. Biochem. Nutr.

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We have previously reported that the risk of type 2 diabetes, early impaired glucose tolerance, and insulin resistance can be predicted using fasting levels of adiponectin, leptin, and insulin. Here, we aimed to evaluate the utility of hemoglobin A1c in detecting the risk of type 2 diabetes compared with other well known biomarkers. We randomly enrolled 207 volunteers with no history of diseases, who underwent 75 g oral glucose tolerance tests and were stratified into normal, borderline, abnormal, or diabetic groups. Eighty one participants with normal baseline levels of hemoglobin A1c (<6.0%) were included in the normal groups of both glucose tolerance and insulin resistance. Hemoglobin A1c was significantly correlated with the plasma glucose and insulin resistance index. Leptin, adiponectin, glycoalbumin, and body mass index also were correlated well with plasma glucose levels and insulin resistance index. Normal hemoglobin A1c levels with abnormal glucose tolerance and insulin resistance were noted in 85 and 67 participants, respectively. Hemoglobin A1c did not strengthen the prediction algorithm of diabetes, determined by our proposed biomarkers, leptin, adiponectin, and insulin. In conclusion, hemoglobin A1c is a surrogate biomarker for risk of diabetes, with inadequate predictive value, and should be used in combination with other biomarkers.

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Urinary pH reflects dietary acid load in patients with type 2 diabetes

Cited by 17 publications

References 30 publications

Nonalcoholic fatty liver disease remission in men through regular exercise

Nonalcoholic fatty liver disease remission in men through regular exercise

Intake of Carbohydrate to Fiber Ratio Is a Useful Marker for Metabolic Syndrome in Patients with Type 2 Diabetes: A Cross-Sectional Study

Utility of hemoglobin A1c in detecting risk of type 2 diabetes: comparison of hemoglobin A1c with other biomarkers

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