Urinary beta-trace protein as a tubular marker of renal dysfunction in patients with chronic kidney disease

β-Trace Protein: A Marker of GFR and Other Biological Pathways

“…43,44,89 In one study, urinary BTP levels were found to be significantly higher in a CKD cohort than in an apparently healthy cohort (3.93 vs 2.02 mg/d). 43 Similar findings were seen in hypertensive patients without evidence of kidney disease and in patients with early diabetic nephropathy compared with healthy controls. 42,44 It should be noted that unlike cystatin C, b 2 microglobulin, and a 1 microglobulin, BTP does not undergo significant tubular reabsorption in healthy tubules, which argues against tubular dysfunction as the sole explanation for increased urinary levels.…”

“…Freely filtered, these are reabsorbed and metabolized by proximal tubular cells and therefore are absent from urine in individuals without tubular dysfunction. 43 BTP also has been investigated as a marker of proximal tubular damage. 43,44,89 In one study, urinary BTP levels were found to be significantly higher in a CKD cohort than in an apparently healthy cohort (3.93 vs 2.02 mg/d).…”

“…43 BTP also has been investigated as a marker of proximal tubular damage. 43,44,89 In one study, urinary BTP levels were found to be significantly higher in a CKD cohort than in an apparently healthy cohort (3.93 vs 2.02 mg/d). 43 Similar findings were seen in hypertensive patients without evidence of kidney disease and in patients with early diabetic nephropathy compared with healthy controls.…”

β-Trace Protein

“…Urinary excretion of BTP has, thus, been used as a marker of renal dysfunction in animal models (39) and human studies (37,38,40,41). In a rat model experiment, a genetic model of spontaneous noninsulin-dependent diabetes mellitus accompanied by kidney dysfunction was used (39).…”

“…Subsequently, two different studies with patients suffering from CKD showed that BTP was a useful marker for the early detection of renal tubular damage and that a BTP urine-based test can predict a slight GFR impairment in CKD patients (40,41).…”