β-Trace Protein

Orenes‐Piñero, Esteban; Manzano‐Fernández, Sergio; López‐Cuenca, Ángel; Marín, Francisco; Valdés, Mariano; Januzzi, James L.

doi:10.2215/cjn.08870812

Cited by 36 publications

(34 citation statements)

References 55 publications

(88 reference statements)

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“…Second, the low BTP levels found in our large amputees could contribute to cardiovascular risk. BTP promotes vasodilatation, induces endothelial atheroprotection, decreases platelet aggregation, stabilizes atherosclerotic plaques, and inhibits adipogenesis [33]. Also, in a study of 3,136 NHANES III participants, subjects with BTP levels in the lowest quartile were more than twice as likely as those in the highest quartile to have metabolic syndrome [34].…”

Section: Discussionmentioning

confidence: 99%

Effects of Traumatic Amputation on β-Trace Protein and β2-Microglobulin Concentrations in Male Soldiers

Little

Yuan²,

Thurlow³

et al. 2015

Am J Nephrol

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Background: Serum creatinine (SCr) levels are decreased following traumatic amputation, leading to the overestimation of glomerular filtration rate (GFR). β-Trace protein (BTP) and β₂-microglobulin (B2M) strongly correlate with measured GFR and have not been studied following amputation. We hypothesized that BTP and B2M would be unaffected by traumatic amputation. Methods: We used the Department of Defense Serum Repository to compare pre- and post-traumatic amputation serum BTP and B2M levels in 33 male soldiers, via the N Latex BTP and B2M nephelometric assays (Siemens Diagnostics, Tarrytown, N.Y., USA). Osterkamp estimation using DEXA scan measurements was used to establish percent estimated body weight loss (%EBWL). Results were analyzed for small (3-5.9% EBWL), medium (6-13.5%), and large (>13.5%) amputation subgroups; and for a control group matched 1:1 to the 12 large amputation subjects. Paired Student's t test was used for comparisons. Results: Mean serum BTP levels were unchanged in controls, all amputees, and the small and medium amputation subgroups. BTP appeared to decrease following large %EBWL amputation (p = 0.05). Mean serum B2M levels were unchanged in controls, all amputees, and the small and medium amputation subgroups. B2M appeared to increase following large %EBWL amputation (p = 0.05). Conclusions: BTP and B2M levels are less affected than SCr by amputation, and should be considered for future study of GFR estimation. BTP and B2M changes following large %EBWL amputation require validation and may offer insight into non-GFR BTP and B2M determinants as well as increased cardiovascular disease and mortality following amputation. This is a work of the US Government and is not subject to copyright protection in the USA. Foreign copyrights may apply. Published by S. Karger AG, Basel

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Section: Discussionmentioning

confidence: 99%

Effects of Traumatic Amputation on β-Trace Protein and β2-Microglobulin Concentrations in Male Soldiers

Little

Yuan²,

Thurlow³

et al. 2015

Am J Nephrol

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“…53 In a cohort of 1,157 elderly women, ele vated serum levels of osteoprotegerin (tumour necrosis factor receptor superfamily member 11B) were predic tive of a decline in renal function. 54 Circulating levels of tumour necrosis factor receptor superfamily member 1A (TNFR1) were a significant predictor of allcause mor tality in 522 patients with type 2 diabetes and CKD, 55 further supporting the hypothesis that inflammation is relevant to progression of CKD.…”

Section: Markers Of Inflammation and Oxidative Stressmentioning

confidence: 99%

Proteomic biomarkers in kidney disease: issues in development and implementation

et al. 2015

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Proteomic biomarkers offer the hope of improving the management of patients with kidney diseases by enabling more accurate and earlier detection of renal pathology than is possible with currently available biomarkers, serum creatinine and urinary albumin. In addition, proteomic biomarkers could also be useful to define the most suitable therapeutic targets in a given patient or disease setting. This Review describes the current status of proteomic and protein biomarkers in the context of kidney diseases. The valuable lessons learned from early clinical studies of potential proteomic biomarkers in kidney disease are presented to give context to the newly identified biomarkers, which have potential for actual clinical implementation. This article also includes an overview of protein-based biomarker candidates that are undergoing development for use in nephrology, focusing on those with the greatest potential for clinical implementation. Relevant issues and problems associated with the discovery, validation and clinical application of proteomic biomarkers are discussed, along with suggestions for solutions that might help to guide the design of future proteomic studies. These improvements might remove some of the current obstacles to the utilization of proteomic biomarkers, with potentially beneficial results.

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“…[27], [28] β-trace protein has also emerged as a promising, novel endogenous marker for the GFR, representing a more sensitive marker for mild kidney dysfunction than serum creatinine. [29], [30] However, our results provide evidence (i) that proteinuria could be present in the early post-resuscitative period and (ii) that proteinuria is associated with certain symptoms of capillary leakage and with patient outcomes. The major limitation of this retrospective study was the determination of the histories of proteinuria (or baseline proteinuria levels).…”

Section: Discussionmentioning

confidence: 62%

The Post-Resuscitative Urinalysis Associate the Survival of Patients with Non-Traumatic Out-of-Hospital Cardiac Arrest

Chang

et al. 2013

PLoS ONE

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ObjectiveTo analyze whether urine output and urinalysis results are predictive of survival and neurologic outcomes in patients with non-traumatic out-of-hospital cardiac arrest (OHCA).MethodsInformation was obtained from 1,340 patients with non-traumatic OHCA who had achieved a sustained return of spontaneous circulation (ROSC). Factors that were associated with survival in the post-resuscitative period were evaluated. The association between urine output and fluid challenge in the early resuscitative period was analyzed and compared between the survivors and the non-survivors. The results of the initial urinalysis, including the presence of proteinuria and other findings, were used to evaluate the severity of vascular protein leakage and survival. The association between proteinuria and the neurologic outcomes of the survivors was also analyzed. The clinical features of capillary leakage were examined during the post-resuscitative period.ResultsOf the 1,340 patients, 312 survived. A greater urine output was associated with a higher chance of survival. The initial urine output increased in proportion to the amount of fluid that was administered during early resuscitation in the emergency department for the survivors but not for the non-survivors (p<0.05). In the initial urinalysis, proteinuria was strongly associated with survival, and severe proteinuria indicated significantly poorer neurologic outcomes (p<0.05 for both comparisons). Proteinuria was associated with a risk of developing signs of capillary leakage, including body mass index gain and pitting edema (both p<0.001).ConclusionThe severity of proteinuria during the early post-resuscitative period was predictive of survival.

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β-Trace Protein

Cited by 36 publications

References 55 publications

Effects of Traumatic Amputation on β-Trace Protein and β2-Microglobulin Concentrations in Male Soldiers

Effects of Traumatic Amputation on β-Trace Protein and β2-Microglobulin Concentrations in Male Soldiers

Proteomic biomarkers in kidney disease: issues in development and implementation

The Post-Resuscitative Urinalysis Associate the Survival of Patients with Non-Traumatic Out-of-Hospital Cardiac Arrest

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