Beta-trace protein as a marker of GFR — History, indications, and future research

Filler, Guido; Kusserow, Carola; Lopes, Laudelino Marques; Kobrzyński, Marta

doi:10.1016/j.clinbiochem.2014.04.027

Cited by 37 publications

(37 citation statements)

References 106 publications

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“…The volume of distribution of cystatin C is most likely the extracellular volume (ECV), which correlates better with lean body mass than body surface area [9]. While BTP is produced in the coronary arteries (reviewed recently by Filler et al [10], the differing fat mass between the genders has been shown to affect BTP-based GFR estimates [2]. Its volume of distribution is unknown [10].…”

Section: Discussionmentioning

confidence: 99%

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Can the new CKD-EPI BTP-B2M formula be applied in children?

et al. 2016

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Although measuring creatinine to determine kidney function is currently the clinical standard, new markers such as beta-trace protein (BTP) and beta-2-microglobulin (B2M) are being investigated in an effort to measure glomerular filtration rate more accurately. In their recent publication, Inker et al. (Am J Kidney Dis 2015; 67:40-48) explored the use of these two relatively new markers in combination with some commonly available clinical characteristics in a large cohort of adults with chronic kidney disease. Their research led them to develop three formulae using BTP, B2M, and a combination of the two. The combined formula is particularly attractive as it removes all gender bias, which applies to both serum creatinine and cystatin C. Using data from a cohort of 127 pediatric patients from our center, we sought to determine whether these formulae would be equally as effective in children as in adults. Unfortunately, we found that the formulae cannot be applied to the pediatric population.

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Section: Discussionmentioning

confidence: 99%

“…While BTP is produced in the coronary arteries (reviewed recently by Filler et al [10], the differing fat mass between the genders has been shown to affect BTP-based GFR estimates [2]. Its volume of distribution is unknown [10]. B2M is a component of MHC class I molecules, which are present on all nucleated cells.…”

Section: Discussionmentioning

confidence: 99%

Can the new CKD-EPI BTP-B2M formula be applied in children?

et al. 2016

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“…The idea of using endogenous small molecular weight proteins as markers of GFR is not new [54]. Contenders include CysC [55], b-trace protein (BTP) [56], and b-2 microglobulin (B2M) [57,58]. Of these, CysC is the most studied.…”

Section: Alternative Endogenous Biomarkers Of Glomerular Filtration Ratementioning

confidence: 99%

Assessment of glomerular filtration rate in the neonate

Filler

Guerrero-Kanan

Álvarez-Elías

2016

Current Opinion in Pediatrics

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“…Several authors suggest that CysC does not cross the placenta [34][35][36], but recent evidence supporting the diaplacental transport of CysC has emerged [4,18], although the transport found was much less pronounced than that of serum Cr. Another potential low-molecular-weight protein marker is beta-trace protein (BTP) [37]. BTP may be a superior marker for neonates as it does not seem to cross the placenta [38].…”

Section: Is Cysc the Best Marker Of Neonatal Renal Function?mentioning

confidence: 99%

A step forward towards accurately assessing glomerular filtration rate in newborns

Filler

2015

Pediatr Nephrol

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In this edition of Pediatric Nephrology, Milena Treiber and colleagues have published a study on cystatin C (CysC) concentrations in relation to renal volumetry in 50 small-for-gestational age (SGA) and 50 appropriate-for-gestational age (AGA) neonates, deriving a new formula for estimating neonatal glomerular filtration rate (GFR). The study builds on previous work which established that renal volumetry together with CysC blood levels is a superior method for establishing GFR in term and pre-term newborns [The Journal of Pediatrics (2014) 164:1026-1031.e2]. Treiber et al. use the expected difference between SGA and AGA renal volumes to document the superiority of their new formula, which is based on total renal volume, CysC and body surface area, but does not incorporate gold-standard inulin clearance. Treiber et al.'s study adds new knowledge to the field that will hopefully improve the safety of renally excreted critical dose drugs in the newborn period. This editorial discusses the strengths and limitations of the current study.

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Beta-trace protein as a marker of GFR — History, indications, and future research

Cited by 37 publications

References 106 publications

Can the new CKD-EPI BTP-B2M formula be applied in children?

Can the new CKD-EPI BTP-B2M formula be applied in children?

Assessment of glomerular filtration rate in the neonate

A step forward towards accurately assessing glomerular filtration rate in newborns

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