A step forward towards accurately assessing glomerular filtration rate in newborns

Filler, Guido

doi:10.1007/s00467-014-3014-1

Cited by 11 publications

(5 citation statements)

References 40 publications

(45 reference statements)

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“…This equation may represent a significant step forward toward accurately assessing GFR in newborns; however, it requires further validation with inulin clearance. 37…”

Section: Discussionmentioning

confidence: 99%

Glomerular Filtration Rate Estimation Formulas for Pediatric and Neonatal Use

Muhari-Stark¹,

Burckart²

2018

The Journal of Pediatric Pharmacology and Therapeutics

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Renal function assessment is of the utmost importance in predicting drug clearance and in ensuring safe and effective drug therapy in neonates. The challenges to making this prediction relate not only to the extreme vulnerability and rapid maturation of this pediatric subgroup but also to the choice of renal biomarker, covariates, and glomerular filtration rate (GFR) estimating formula. In order to avoid burdensome administration of exogenous markers and/or urine collection in vulnerable pediatric patients, estimation of GFR utilizing endogenous markers has become a useful tool in clinical practice. Several estimation methods have been developed over recent decades, exploiting various endogenous biomarkers (serum creatinine, cystatin C, blood urea nitrogen) and anthropometric measures (body length/height, weight, muscle mass). This article reviews pediatric GFR estimation methods with a focus on their suitability for use in the neonatal population.

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“…This equation may represent a significant step forward toward accurately assessing GFR in newborns; however, it requires further validation with inulin clearance. 37…”

Section: Discussionmentioning

confidence: 99%

Glomerular Filtration Rate Estimation Formulas for Pediatric and Neonatal Use

Muhari-Stark¹,

Burckart²

2018

The Journal of Pediatric Pharmacology and Therapeutics

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“…It is known that during the first days of life, blood serum creatinine reflects maternal creatinine. Our results for creatinine in urine showed a peak at 36–48 h, which could be due to passive reabsorption across immature renal tubules that occurs in the first days of life [ 33 , 34 ]. In addition, in those first days, there are more intense changes, both in the hemodynamic and intravascular space, as well as elevation of bilirubin, which would produce greater variability in creatinine levels [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Biomarkers of Oxidative Stress in Healthy Infants within the First Three Days after Birth

Cavia-Saiz,

Arnaez,

Cilla

et al. 2023

Antioxidants

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The clinical relevance of stress biomarkers in newborns is well established. Currently, oxidative stress (OS) parameters are seen to play an important role in neonatal resuscitation guidelines, and a link has been observed between the amount of oxygen delivered and the level of OS and the development of various pathologies. The aim of the current study was to investigate changes in neonatal plasma and urine OS status during the first hours after birth. A lower antioxidant capacity (TAC) and higher levels of malondialdehyde in blood were observed in newborns at the time of birth compared with results 48 h postnatally. The urine revealed a significant and progressive increase in TAC and creatinine during the first 36 h of life, with a progressive decline thereafter. Meanwhile, malondialdehyde in urine samples showed no significant differences over time. Overall, the correlation between blood and urine parameters was poor, except for the relationship between umbilical vein glutathione reduced/oxidized ratio and urine malondialdehyde (r = 0.7; p = 0.004) and between TAC in the umbilical artery and urine (r = −0.547; p = 0.013). The biomarkers evaluated in this study could be established as reference values for neonatal OS.

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“…Rapid assessment of glomerular filtration rates (GFR) in infants is imperative for both drug dosing and recognition of acute kidney injury (AKI) [1][2][3]. This is especially important in low birth weight and preterm neonates who have an increased risk of AKI and development of chronic kidney disease (CKD) [4].…”

Section: Introductionmentioning

confidence: 99%