Urinary 8‐hydroxy‐2′‐deoxyguanosine reflects symptomatic status and severity of systolic dysfunction in patients with chronic heart failure

Kobayashi, Shigeki; Susa, Takehisa; Tanaka, Takeo; Wada, Yasuaki; Okuda, Shinichi; Doi, Masahiro; Nao, Tomoko; Yoshiga, Yasuhiro; Yamada, Jiro; Okamura, Takayuki; Ueyama, Takeshi; Kawamura, Syuji; Yano, Masafumi; Matsuzaki, Masunori

doi:10.1093/eurjhf/hfq178

Cited by 57 publications

(40 citation statements)

References 41 publications

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“…Increased oxidative stress is detected in most types of HF, that resulting from ischaemic and non-ischaemic cardiomyopathy, pressure and volume overload, tachycardiomyopathy [9]. The side effects of oxidative stress in HF patients are vascular endothelial dysfunction [10], cardiac hypertrophy [11] and myocyte contractile dysfunction [12].…”

Section: Introductionmentioning

confidence: 99%

The possible protective role of quercetin on induced cardiac Oxidative DNA Damage by repeated exposure to diesel exhaust nanoparticles in rats (a histological and immunohistochemical study)

Faruk¹,

Mansy²,

ALasmari³

et al. 2018

J Histol Histopathol

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Diesel exhaust nanoparticles (DENPs) are gaseous exhaust and one component of particulate matter (PM) air pollution which is found to cause health hazards in humans. Quercetin is widely known for its antioxidant and antitoxic potential. We aimed todetect the protective effect of quercetin in DENP-induced cardio toxicity. Fifty Malealbino rats were divided into two groups,first group (ten rats) divided into two equal subgroups (one receive saline act as control and other receive quercetin,the second group (forty rats)divided equally into two subgroups (one was treated with repeated doses of DENPs [90µg/ rat and 180µg/ rat for 6 days intratracheally every two days] and other treated orally with quercetin (60 mg/kg B.Wt.) 1h prior to DENP exposure,DNA damagewas examined by measureserum8-hydroxydeoguanosine (8-OHdG) levels followed by histological and immunohistochemical studies for nuclear factor-kappa B(NF-κB) expression in heart tissues. Tumor necrosis factor-alpha (TNFα), interleukin-6 (IL-6) and serum level 8-Ohd Gare significantly higher in repeated doses of DENPs than the control group. Pretreatment with quercetin reduced significantly serum level 8-OhdGwhen compared to DENPs group.Cardiac myocytes disruption, vacuolation, inflammation and wide separation of its fibers in contrast to control group. Myocyteinflammations were significantly decreased with quercetin group compared with control group (decrease NF-κBimmunostaining). The present work yields experimentalevidence that quercetin can reduce oxidative DNA damage and inflammation induced by DENPs, so suggested that quercetin possible cardioprotective effect against DENPs.

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Section: Introductionmentioning

confidence: 99%

The possible protective role of quercetin on induced cardiac Oxidative DNA Damage by repeated exposure to diesel exhaust nanoparticles in rats (a histological and immunohistochemical study)

Faruk¹,

Mansy²,

ALasmari³

et al. 2018

J Histol Histopathol

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“…42) Kobayashi, et al showed that urinary 8-OHdG was higher in heart failure patients than in control subjects, and that urinary 8-OHdG became higher as the NYHA class increased. 43) Moreover, there was a significant correlation between urinary 8-OHdG and cardiac functional parameters. BIOMARKERS IN HEART FAILURE Suzuki, et al measured serum 8-OHdG levels in 230 patients with chronic heart failure and 42 control subjects without heart failure by a sandwich ELISA.…”

Section: )mentioning

confidence: 91%

Biomarkers in Heart Failure

Takeishi

2014

Int. Heart J.

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SummaryAppropriate use of biomarkers is clinically important for identifying heart failure in its early stage, optimizing risk stratification, and managing patients. This article describes established and traditional biomarkers as well as novel biomarkers reflective of myocardial stress, myocardial damage, extracellular matrix, oxidative stress, inflammation, renal function, micro RNAs, and heart failure with preserved left ventricular ejection fraction. This review focuses on the recent advances in cardiac and non-cardiac biomarkers of heart failure and their appropriate use in clinical practice. (Int Heart J 2014; 55: 474-481) Key words: BNP, NT-proBNP, ST2, Troponin, H-FABP, Galectin-3, Cystatin C, Pentraxin 3 C ardiovascular diseases are the predominant cause of death in developed countries. Among the afflicted, patients with heart failure are increasing, and this complex syndrome is becoming a public health problem, especially with the aging of populations. To establish diagnostic, therapeutic, and prognostic strategies, the identification of reliable biomarkers for heart failure is necessary.1,2) Although a number of biomarkers have been developed, the ideal biomarkers should meet certain criteria: 1) non-invasive sample collection, 2) a high degree of sensitivity and specificity, 3) able to detect the disease at an early stage, 4) sensitivity high enough to reflect relevant changes in disease conditions, 5) a long halflife within the sample, 6) rapid measurement system responding to clinical needs, and 7) low cost. 3,4) In this article, the focus will be on the recent advances in cardiac and non-cardiac biomarkers of heart failure and their appropriate use in clinical practice. Myocardial Stress MarkersB-type natriuretic peptide: B-type natriuretic peptide (BNP) is a well-established biomarker, extensively used for the diagnosis and prognosis of patients with heart failure. BNP is a cardiac hormone, identified as the second compound of the natriuretic peptide family and secreted predominantly from the ventricle in response to mechanical overload. 5) In the failing heart, increased wall stress and neurohormonal activation facilitate BNP secretion chiefly from ventricular myocytes. BNP promotes diuresis, vasodilatation, and attenuation of renin and aldosterone secretion. Tsutamoto, et al initially measured plasma levels of BNP in 85 patients with chronic heart failure and a left ventricular ejection fraction (LVEF) of less than 0.45. 6)The plasma levels of BNP increased in proportion to the severity of heart failure. Plasma levels of BNP were 5-fold higher in non-survivors than in survivors. Among clinical and hemodynamic parameters, Cox proportional hazard analysis revealed that only plasma BNP (P < 0.0001) and pulmonary capillary wedge pressure (P = 0.003) were significant independent predictors of mortality in patients with heart failure. Plasma levels of BNP provided prognostic information independent of other variables previously associated with a poor prognosis. To date, a number of studies have r...

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“…29 Recently, we reported that 8-OHdG is produced in failing cardiac tissue on the basis of sampling data from the coronary sinus and aortic root. 30 In addition, the urinary excretion of 8-OHdG is significantly correlated with clinical status and cardiac dysfunction in patients with CHF. 30 Thus, urinary (U) 8-OHdG may be a useful cardiac biomarker for evaluating oxidative stress at the cellular level and predicting the outcome of patients with CHF.…”

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confidence: 99%

“…30 In addition, the urinary excretion of 8-OHdG is significantly correlated with clinical status and cardiac dysfunction in patients with CHF. 30 Thus, urinary (U) 8-OHdG may be a useful cardiac biomarker for evaluating oxidative stress at the cellular level and predicting the outcome of patients with CHF. In the present study, we investigated whether U8-OHdG is a clinically useful biomarker for predicting the morbidity and mortality of patients with CHF compared with plasma BNP -the current gold standard biomarker for heart failure -and other neurohumoral factors.…”

mentioning

confidence: 99%

Urinary 8-Hydroxy-2'-Deoxyguanosine as a Novel Biomarker for Predicting Cardiac Events and Evaluating the Effectiveness of Carvedilol Treatment in Patients With Chronic Systolic Heart Failure

Susa

Kobayashi

Tanaka

et al. 2012

Circ J

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Urinary 8‐hydroxy‐2′‐deoxyguanosine reflects symptomatic status and severity of systolic dysfunction in patients with chronic heart failure

Abstract: In HF, urinary 8-OHdG seems to reflect the level of oxidative stress and various parameters related to symptomatic status and functional severity of CHF.

Cited by 57 publications

References 41 publications

The possible protective role of quercetin on induced cardiac Oxidative DNA Damage by repeated exposure to diesel exhaust nanoparticles in rats (a histological and immunohistochemical study)

The possible protective role of quercetin on induced cardiac Oxidative DNA Damage by repeated exposure to diesel exhaust nanoparticles in rats (a histological and immunohistochemical study)

Biomarkers in Heart Failure

Urinary 8-Hydroxy-2'-Deoxyguanosine as a Novel Biomarker for Predicting Cardiac Events and Evaluating the Effectiveness of Carvedilol Treatment in Patients With Chronic Systolic Heart Failure

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