Uric acid is associated with long-term adverse cardiovascular outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention

Tscharre, Maximilian; Herman, Robert; Rohla, Miklós; Hauser, Christina; Farhan, Serdar; Freynhofer, Matthias K.; Huber, Kurt; Weiss, Thomas W.

doi:10.1016/j.atherosclerosis.2018.02.003

Cited by 51 publications

(48 citation statements)

References 46 publications

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“…After full‐text assessment, 65 articles were further excluded with various reasons. Finally, nine studies included in the meta‐analysis (Figure ).…”

Section: Resultsmentioning

confidence: 99%

“…Mean/median age of the patients ranged from 57.1 to 68.1 years. These studies were performed in China, Japan, Indonesia, Portugal, Italy, Spain and Austria . Two studies were prospective designs, and others were retrospective designs.…”

Section: Resultsmentioning

confidence: 99%

“…A comprehensive literature search was made in Pubmed, Embase, VIP, CNKI and WanFang databases up to 16 June 2018. The search strategy consisted of the following keywords: "hyperuricemia" OR "uric acid" AND "acute coronary syndrome" OR "AMI" OR "unstable angina" AND "mortality" OR "death" OR "MACEs" AND "prognostic" OR "prognosis."…”

Section: Literature Searchmentioning

confidence: 99%

“…These studies were performed in China 10,12,17 , Japan 13 , Indonesia 5 , Portugal 11 , Italy 14 , Spain 15 and Austria. 16 Two studies 11,15 were prospective designs, and others were retrospective designs. The lengths of follow-up duration were up to 5.5 years.…”

Section: Literature Search and Studies Characteristicsmentioning

confidence: 99%

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Prognostic value of hyperuricemia in patients with acute coronary syndrome: A meta‐analysis

He¹,

Lin²,

Liu³

et al. 2019

Eur J Clin Investigation

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Background The prognostic significance of elevated circulating uric acid level in patients with acute coronary syndrome (ACS) is conflicting. This meta‐analysis aimed to assess the prognostic value of hyperuricemia in patients with ACS. Methods A comprehensive literature search was performed in Pubmed, Embase, VIP, CNKI and WanFang databases up to 16 June 2018. All observational studies that investigated the prognostic value of hyperuricemia in ACS patients were selected. Outcome of interests was major adverse cardiovascular events (MACEs), all‐cause mortality or cardiovascular mortality. Results A total of nine studies enrolling 8776 ACS patients were included and analysed. ACS patients with hyperuricemia had an increased risk of MACEs (risk ratio [RR]: 1.86; 95% confidence intervals [CI]: 1.47‐2.35), all‐cause mortality (RR 1.86; 95% CI: 1.49‐2.32) and cardiovascular mortality (RR: 1.74; 95% CI: 1.36‐2.22) after adjustment for the conventional risk factors. Stratified analysis showed that the prognostic significance of hyperuricemia was consistently observed in each subgroups. Conclusions This meta‐analysis suggests that hyperuricemia independently predicts MACEs and death in ACS patients. Determination of uric acid level has potential to improve risk stratification of adverse outcomes in ACS patients.

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“…After full‐text assessment, 65 articles were further excluded with various reasons. Finally, nine studies included in the meta‐analysis (Figure ).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Literature Searchmentioning

confidence: 99%

Section: Literature Search and Studies Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

Prognostic value of hyperuricemia in patients with acute coronary syndrome: A meta‐analysis

He¹,

Lin²,

Liu³

et al. 2019

Eur J Clin Investigation

View full text Add to dashboard Cite

show abstract

“…The relationship between SUA and cardiovascular disease in the general population has been reported by several studies. 3,18,19 A recent meta-analysis study found that hyperuricemia was risk factor for the presence of CAD. 18 Another prospective study also confirmed that hyperuricemia conferred 1.6-fold increased relative risk for cardiovascular death and a 1.5-fold increased risk for myocardial infarction in patients who had received PCI.…”

Section: Discussionmentioning

confidence: 99%

Association Between the Serum Uric Acid Level and the Severity of Coronary Artery Disease in a Retrospective Study of China Nondialysis CKD Patients

Yang

Lin

Gao

et al. 2020

Metabolic Syndrome and Related Disorders

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Introduction: Hyperuricemia has been associated with increased cardiovascular events in the general population. However, the role of serum uric acid (SUA) level on the severity of coronary artery stenosis (CAS) in nondialysis chronic kidney disease (CKD) patients is obscure. Methods: We implement a retrospective cohort study of 734 patients diagnosed with stage 3-5 CKD. All selected patients underwent coronary artery angiography. The associations of SUA with the present, and severity of coronary artery disease (CAD) were analyzed. Results: Of these 734 patients, 511 patients had angiographically proven CAD. Compared with non-CAD group, the SUA level in CAD group was much higher (388.00 vs. 363.00 mmol/l, P < 0.01). After adjusting for multiple confounding factors, a multivariate logistic regression analysis demonstrated that SUA was relevant to the presence of CAD when SUA as a continuous variable. However, this relationship was not observed with SUA as a categorical variable. In a subgroup analysis for the CAD group, we found that the rates of severe CAS in the third tertile of SUA (58.6%) was higher than that in the first tertile (41.6%) (P < 0.01). Compared with the first tertile of SUA, the third tertile of SUA was an independent risk factor for severe arterial stenosis (odds ratio, OR,), a pattern that was recapitulated by multivariate logistic regression analysis with SUA as a continuous variable (1.002 [1.000-1.004]). Conclusions: The SUA level may serve as a predictor of the severity of CAS among nondialysis CKD patients with CAD.

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Prognostic value of serum uric acid levels in patients with non-STEMI undergoing percutaneous coronary intervention

Çanga

Emre

Karataş

et al. 2019

Herz

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Uric acid is associated with long-term adverse cardiovascular outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention

Cited by 51 publications

References 46 publications

Prognostic value of hyperuricemia in patients with acute coronary syndrome: A meta‐analysis

Prognostic value of hyperuricemia in patients with acute coronary syndrome: A meta‐analysis

Association Between the Serum Uric Acid Level and the Severity of Coronary Artery Disease in a Retrospective Study of China Nondialysis CKD Patients

Prognostic value of serum uric acid levels in patients with non-STEMI undergoing percutaneous coronary intervention

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